| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $49,087,101 | 4,125 | $295,983,305 | Nov 19 | Warner Bros. | false |
| 2 | Tangled | - | - | - | $48,767,052 | 3,603 | $200,821,936 | Nov 24 | Walt Disney Studios Motion Pictures | false |
| 3 | Megamind | - | - | - | $12,575,778 | 3,949 | $148,415,853 | Nov 5 | DreamWorks | false |
| 4 | Burlesque | - | - | - | $11,947,744 | 3,037 | $39,440,655 | Nov 24 | Screen Gems | false |
| 5 | Unstoppable | - | - | - | $11,432,903 | 3,261 | $81,562,942 | Nov 12 | Twentieth Century Fox | false |
| 6 | Love & Other Drugs | - | - | - | $9,739,161 | 2,458 | $32,367,005 | Nov 24 | Twentieth Century Fox | false |
| 7 | Faster | - | - | - | $8,523,153 | 2,470 | $23,240,020 | Nov 24 | CBS Films | false |
| 8 | Due Date | - | - | - | $7,167,885 | 3,365 | $100,539,043 | Nov 5 | Warner Bros. | false |
| 9 | The Next Three Days | - | - | - | $4,683,123 | 2,564 | $21,148,651 | Nov 19 | Lionsgate | false |
| 10 | Morning Glory | - | - | - | $3,910,058 | 2,544 | $31,011,732 | Nov 10 | Paramount Pictures | false |
| 11 | 127 Hours | - | - | - | $1,708,883 | 916 | $18,335,230 | Nov 5 | Fox Searchlight Pictures | false |
| 12 | Fair Game | - | - | - | $1,560,189 | 436 | $9,540,691 | Nov 5 | Summit Entertainment | false |
| 13 | RED | - | - | - | $1,375,685 | 3,349 | $90,380,162 | Oct 15 | Summit Entertainment | false |
| 14 | For Colored Girls | - | - | - | $1,362,287 | 2,127 | $37,729,698 | Nov 5 | Lionsgate | false |
| 15 | Skyline | - | - | - | $1,141,440 | 2,883 | $21,393,620 | Nov 12 | Universal Pictures | false |
| 16 | The Social Network | - | - | - | $707,153 | 2,921 | $96,962,694 | Oct 1 | Sony Pictures Releasing | false |
| 17 | Secretariat | - | - | - | $647,172 | 3,108 | $59,713,955 | Oct 8 | Walt Disney Studios Motion Pictures | false |
| 18 | The Girl Who Kicked the Hornet's Nest | - | - | - | $390,888 | 208 | $5,190,196 | Oct 29 | Music Box Films | false |
| 19 | Despicable Me | - | - | - | $363,090 | 3,602 | $251,639,815 | Jul 9 | Universal Pictures | false |
| 20 | The King's Speech | - | - | - | $355,450 | 2,584 | $135,453,143 | Nov 26 | The Weinstein Company | false |
| 21 | The Town | - | - | - | $314,720 | 2,935 | $92,186,262 | Sep 17 | Warner Bros. | false |
| 22 | Inside Job | - | - | - | $307,389 | 250 | $4,312,735 | Oct 8 | Sony Pictures Classics | false |
| 23 | Paranormal Activity 2 | - | - | - | $220,108 | 3,239 | $84,752,907 | Oct 22 | Paramount Pictures | false |
| 24 | Easy A | - | - | - | $200,991 | 2,974 | $58,401,464 | Sep 17 | Screen Gems | false |
| 25 | Hubble | - | - | - | $196,429 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 26 | Break Ke Baad | - | - | - | $194,737 | 85 | $427,628 | Nov 24 | Reliance Big Pictures | false |
| 27 | Guzaarish | - | - | - | $188,085 | 108 | $1,017,335 | Nov 19 | UTV Motion Pictures | false |
| 28 | Jackass 3D | - | - | - | $182,055 | 3,139 | $117,229,692 | Oct 15 | Paramount Pictures | false |
| 29 | Alpha and Omega | - | - | - | $165,947 | 2,625 | $25,107,267 | Sep 17 | Lionsgate | false |
| 30 | Life as We Know It | - | - | - | $154,381 | 3,150 | $53,374,681 | Oct 8 | Warner Bros. | false |
| 31 | Saw 3D | - | - | - | $131,305 | 2,808 | $45,710,178 | Oct 29 | Lionsgate | false |
| 32 | You Again | - | - | - | $120,285 | 2,548 | $25,702,053 | Sep 24 | Walt Disney Studios Motion Pictures | false |
| 33 | Inception | - | - | - | $119,466 | 3,792 | $292,576,195 | Jul 16 | Warner Bros. | false |
| 34 | Toy Story 3 | - | - | - | $109,840 | 4,028 | $415,004,880 | Jun 18 | Walt Disney Studios Motion Pictures | false |
| 35 | Today's Special | - | - | - | $87,088 | 55 | $317,831 | Nov 19 | Vitagraph Films | false |
| 36 | Hereafter | - | - | - | $78,909 | 2,424 | $32,746,941 | Oct 15 | Warner Bros. | false |
| 37 | Conviction 2010 Re-release | - | - | - | $73,497 | 672 | $6,783,129 | Oct 15 | Fox Searchlight Pictures | false |
| 38 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $71,735 | 3,575 | $55,675,313 | Sep 24 | Warner Bros. | false |
| 39 | The Nutcracker: The Untold Story | - | - | - | $65,944 | 115 | $195,459 | Nov 24 | Freestyle Releasing | false |
| 40 | Made in Dagenham | - | - | - | $62,316 | 89 | $1,095,369 | Nov 19 | Sony Pictures Classics | false |
| 41 | Waiting for Superman | - | - | - | $60,563 | 330 | $6,417,135 | Sep 24 | Paramount Vantage | false |
| 42 | White Material | - | - | - | $60,152 | 21 | $304,020 | Nov 19 | IFC Films | false |
| 43 | Under the Sea 3D | - | - | - | $53,154 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 44 | You Will Meet a Tall Dark Stranger | - | - | - | $48,613 | 402 | $3,248,246 | Sep 22 | Sony Pictures Classics | false |
| 45 | Wall Street: Money Never Sleeps | - | - | - | $45,395 | 3,597 | $52,474,616 | Sep 24 | Twentieth Century Fox | false |
| 46 | Tiny Furniture | - | - | - | $35,197 | 21 | $391,674 | Nov 12 | IFC Films | false |
| 47 | Tamara Drewe | - | - | - | $31,275 | 59 | $560,391 | Oct 8 | Sony Pictures Classics | false |
| 48 | Mao's Last Dancer | - | - | - | $31,216 | 137 | $4,817,770 | Aug 20 | The Samuel Goldwyn Company | false |
| 49 | Space Station 3D | - | - | - | $25,457 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 50 | Vision | - | - | - | $22,766 | 17 | $435,274 | Oct 13 | Zeitgeist Films | false |
| 51 | Kings of Pastry | - | - | - | $19,314 | 10 | $336,386 | Sep 15 | First Run | false |
| 52 | Four Lions | - | - | - | $18,412 | 18 | $304,616 | Nov 5 | Drafthouse Films | false |
| 53 | Stone | - | - | - | $16,682 | 125 | $1,810,078 | Oct 8 | Overture Films | false |
| 54 | Never Let Me Go | - | - | - | $15,450 | 232 | $2,434,652 | Sep 15 | Fox Searchlight Pictures | false |
| 55 | Client 9 | - | - | - | $15,265 | 17 | $189,416 | Nov 5 | Magnolia Pictures | false |
| 56 | Nowhere Boy | - | - | - | $14,995 | 215 | $1,457,248 | Oct 8 | The Weinstein Company | false |
| 57 | Welcome to the Rileys | - | - | - | $14,358 | 11 | $158,898 | Oct 29 | The Samuel Goldwyn Company | false |
| 58 | Undertow | - | - | - | $13,612 | 3 | $108,620 | Sep 17 | The Film Collaborative | false |
| 59 | Monsters | - | - | - | $13,337 | 25 | $237,301 | Oct 29 | Magnolia Pictures | false |
| 60 | The Legend of Pale Male | - | - | - | $12,910 | 4 | $38,083 | Nov 24 | Balcony Releasing | false |
| 61 | The Wildest Dream | - | - | - | $12,344 | 21 | $898,137 | Aug 6 | National Geographic Entertainment | false |
| 62 | Last Train Home | - | - | - | $9,831 | 14 | $288,328 | Sep 3 | Zeitgeist Films | false |
| 63 | Waste Land | - | - | - | $9,193 | 8 | $187,716 | Oct 29 | Arthouse Films | false |
| 64 | Leaving | - | - | - | $9,045 | 13 | $176,113 | Oct 1 | IFC Films | false |
| 65 | Sea Monsters: A Prehistoric Adventure | - | - | - | $8,945 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 66 | Howl | - | - | - | $8,784 | 29 | $617,334 | Sep 24 | Oscilloscope | false |
| 67 | Galapagos | - | - | - | $8,225 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 68 | Inspector Bellamy | - | - | - | $8,046 | 4 | $107,612 | Oct 29 | IFC Films | false |
| 69 | Catfish | - | - | - | $7,830 | 143 | $3,237,343 | Sep 17 | Rogue Pictures | false |
| 70 | Wild Target | - | - | - | $7,793 | 13 | $108,589 | Oct 29 | Freestyle Releasing | false |
| 71 | Deep Sea | - | - | - | $7,742 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 72 | Enter the Void | - | - | - | $7,569 | 13 | $336,467 | Sep 24 | IFC Films | false |
| 73 | Get Low | - | - | - | $7,512 | 570 | $9,176,933 | Jul 30 | Sony Pictures Classics | false |
| 74 | My Dog Tulip | - | - | - | $7,257 | 5 | $246,574 | Sep 1 | New Yorker Films | false |
| 75 | Let Me In | - | - | - | $6,721 | 2,042 | $12,134,935 | Oct 1 | Overture Films | false |
| 76 | William S. Burroughs: A Man Within | - | - | - | $5,220 | 4 | $46,380 | Nov 17 | Oscilloscope | false |
| 77 | Jack Goes Boating | - | - | - | $4,980 | 90 | $541,992 | Sep 17 | Overture Films | false |
| 78 | Carlos | - | - | - | $4,533 | 7 | $145,526 | Oct 15 | IFC Films | false |
| 79 | Heartbreaker | - | - | - | $4,414 | 43 | $504,030 | Sep 10 | IFC Films | false |
| 80 | Breathless 2010 Re-release | - | - | - | $4,080 | 12 | $363,031 | May 28 | Rialto Pictures | false |
| 81 | Animal Kingdom | - | - | - | $3,520 | 61 | $1,044,039 | Aug 13 | Sony Pictures Classics | false |
| 82 | Marwencol | - | - | - | $3,341 | 6 | $112,036 | Oct 8 | The Cinema Guild | false |
| 83 | The Tillman Story | - | - | - | $2,762 | 28 | $802,535 | Aug 20 | The Weinstein Company | false |
| 84 | The Salvation Poem | - | - | - | $2,668 | 30 | $914,818 | Aug 27 | CanZion Films | false |
| 85 | Genius Within: The Inner Life of Glenn Gould | - | - | - | $2,494 | 9 | $167,508 | Sep 10 | Lorber Films | false |
| 86 | Budrus | - | - | - | $2,247 | 4 | $68,353 | Oct 8 | Balcony Releasing | false |
| 87 | Boxing Gym | - | - | - | $2,036 | 7 | $32,476 | Oct 22 | Zipporah Films | false |
| 88 | Mademoiselle Chambon | - | - | - | $1,599 | 16 | $531,685 | May 28 | Lorber Films | false |
| 89 | The Girl Who Played with Fire | - | - | - | $1,549 | 185 | $7,638,241 | Jul 9 | Music Box Films | false |
| 90 | Dogtooth | - | - | - | $1,122 | 5 | $110,248 | Jun 25 | Kino International | false |
| 91 | I Am Love | - | - | - | $1,111 | 166 | $5,005,465 | Jun 18 | Magnolia Pictures | false |
| 92 | Hideaway | - | - | - | $1,104 | 5 | $34,525 | Sep 10 | Strand Releasing | false |
| 93 | Cool It | - | - | - | $918 | 43 | $62,713 | Nov 12 | Roadside Attractions | false |
| 94 | Freakonomics | - | - | - | $808 | 20 | $101,270 | Oct 1 | Magnolia Pictures | false |
| 95 | Terkel in Trouble 2010 Re-release | - | - | - | $799 | 4 | $40,385 | Oct 15 | Indican Pictures | false |
| 96 | The Girl with the Dragon Tattoo | - | - | - | $762 | 202 | $10,095,170 | Mar 19 | Music Box Films | false |
| 97 | Army of Crime | - | - | - | $704 | 3 | $37,031 | Aug 20 | Lorber Films | false |
| 98 | What If... | - | - | - | $696 | 82 | $814,906 | Aug 20 | Five & Two Pictures | false |
| 99 | Winter's Bone | - | - | - | $646 | 141 | $6,531,503 | Jun 11 | Roadside Attractions | false |
| 100 | Enemies of the People | - | - | - | $620 | 6 | $73,171 | Jul 30 | International Film Circuit | false |
| 101 | A Woman, a Gun and a Noodle Shop | - | - | - | $571 | 23 | $190,946 | Sep 3 | Sony Pictures Classics | false |
| 102 | Le Amiche | - | - | - | $545 | 1 | $68,167 | Jun 18 | The Film Desk | false |
| 103 | Lebanon | - | - | - | $227 | 23 | $368,088 | Aug 6 | Sony Pictures Classics | false |
