| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Four Christmases | - | - | - | $31,069,826 | 3,540 | $120,146,040 | Nov 26 | Warner Bros. | false |
| 2 | Bolt | - | - | - | $26,581,002 | 3,654 | $114,053,579 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 3 | Twilight | - | - | - | $26,344,032 | 3,649 | $192,769,854 | Nov 21 | Summit Entertainment | false |
| 4 | Quantum of Solace | - | - | - | $18,833,552 | 3,501 | $168,368,427 | Nov 14 | Sony Pictures Releasing | false |
| 5 | Australia | - | - | - | $14,800,723 | 2,721 | $49,554,002 | Nov 26 | Twentieth Century Fox | false |
| 6 | Madagascar: Escape 2 Africa | - | - | - | $14,207,329 | 4,065 | $180,010,950 | Nov 7 | DreamWorks | false |
| 7 | Transporter 3 | - | - | - | $12,063,452 | 2,626 | $31,715,062 | Nov 26 | Lionsgate | false |
| 8 | Role Models | - | - | - | $5,284,000 | 2,798 | $67,294,270 | Nov 7 | Universal Pictures | false |
| 9 | The Boy in the Striped Pajamas | - | - | - | $1,696,187 | 679 | $9,046,156 | Nov 7 | Miramax | false |
| 10 | Milk | - | - | - | $1,453,844 | 882 | $31,841,299 | Nov 26 | Focus Features | false |
| 11 | Slumdog Millionaire | - | - | - | $1,346,039 | 2,943 | $141,319,928 | Nov 12 | Fox Searchlight Pictures | false |
| 12 | Changeling | - | - | - | $1,207,240 | 1,896 | $35,739,802 | Oct 24 | Universal Pictures | false |
| 13 | High School Musical 3: Senior Year | - | - | - | $1,061,628 | 3,626 | $90,559,416 | Oct 24 | Walt Disney Studios Motion Pictures | false |
| 14 | The Secret Life of Bees | - | - | - | $561,671 | 1,630 | $37,770,162 | Oct 17 | Fox Searchlight Pictures | false |
| 15 | Rachel Getting Married | - | - | - | $530,210 | 391 | $12,796,841 | Oct 3 | Sony Pictures Classics | false |
| 16 | Zack and Miri Make a Porno | - | - | - | $524,425 | 2,735 | $31,457,946 | Oct 31 | The Weinstein Company | false |
| 17 | Soul Men | - | - | - | $455,335 | 2,048 | $12,082,391 | Nov 7 | Metro-Goldwyn-Mayer (MGM) | false |
| 18 | Fireproof | - | - | - | $431,787 | 905 | $33,456,317 | Sep 26 | The Samuel Goldwyn Company | false |
| 19 | The Dark Knight | - | - | - | $343,366 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 20 | Happy-Go-Lucky | - | - | - | $289,208 | 202 | $3,512,016 | Oct 10 | Miramax | false |
| 21 | Synecdoche, New York | - | - | - | $285,822 | 119 | $3,083,538 | Oct 24 | Sony Pictures Classics | false |
| 22 | Beverly Hills Chihuahua | - | - | - | $253,990 | 3,239 | $94,514,402 | Oct 3 | Walt Disney Studios Motion Pictures | false |
| 23 | Eagle Eye | - | - | - | $247,824 | 3,614 | $101,440,743 | Sep 26 | DreamWorks | false |
| 24 | I've Loved You So Long | - | - | - | $211,806 | 69 | $3,169,305 | Oct 24 | Sony Pictures Classics | false |
| 25 | A Christmas Tale | - | - | - | $160,987 | 52 | $1,060,922 | Nov 14 | IFC Films | false |
| 26 | Yuvvraaj | - | - | - | $158,433 | 77 | $570,090 | Nov 21 | Eros Worldwide | false |
| 27 | The Polar Express 2008 IMAX Release | - | - | - | $157,878 | 26 | $1,705,694 | Nov 21 | Warner Bros. | false |
| 28 | Let the Right One In | - | - | - | $135,692 | 53 | $2,122,065 | Oct 24 | Magnolia Pictures | false |
| 29 | WALL·E | - | - | - | $116,758 | 3,992 | $223,808,164 | Jun 27 | Walt Disney Studios Motion Pictures | false |
| 30 | Saw V | - | - | - | $114,179 | 3,084 | $56,746,769 | Oct 24 | Lionsgate | false |
| 31 | Igor | - | - | - | $110,563 | 2,341 | $19,528,602 | Sep 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 32 | Righteous Kill | - | - | - | $105,423 | 3,152 | $40,081,410 | Sep 12 | Overture Films | false |
| 33 | Friendship | - | - | - | $95,148 | 74 | $1,243,910 | Nov 14 | Yash Raj Films | false |
| 34 | Burn After Reading | - | - | - | $86,900 | 2,657 | $60,355,347 | Sep 12 | Focus Features | false |
| 35 | Body of Lies | - | - | - | $84,944 | 2,714 | $39,394,666 | Oct 10 | Warner Bros. | false |
| 36 | Max Payne | - | - | - | $81,169 | 3,381 | $40,689,393 | Oct 17 | Twentieth Century Fox | false |
| 37 | The Haunting of Molly Hartley | - | - | - | $69,506 | 2,652 | $13,559,812 | Oct 31 | Freestyle Releasing | false |
| 38 | Appaloosa | - | - | - | $67,012 | 1,290 | $20,211,394 | Sep 19 | Warner Bros. | false |
| 39 | Religulous | - | - | - | $62,364 | 568 | $13,011,160 | Oct 1 | Lionsgate | false |
| 40 | W. | - | - | - | $56,678 | 2,050 | $25,534,493 | Oct 17 | Lionsgate | false |
| 41 | City of Ember | - | - | - | $54,470 | 2,023 | $7,873,007 | Oct 10 | Twentieth Century Fox | false |
| 42 | Deep Sea | - | - | - | $49,043 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 43 | JCVD | - | - | - | $46,604 | 28 | $470,691 | Nov 7 | Peace Arch Entertainment Group | false |
| 44 | The Duchess | - | - | - | $46,483 | 1,207 | $13,848,978 | Sep 19 | Paramount Vantage | false |
| 45 | Santa vs. the Snowman 3D 2008 Re-release | - | - | - | $44,448 | 18 | $433,797 | Oct 31 | IMAX | false |
| 46 | Vicky Cristina Barcelona | - | - | - | $43,433 | 726 | $23,216,709 | Aug 15 | Metro-Goldwyn-Mayer (MGM) | false |
| 47 | Oye Lucky! Lucky Oye! | - | - | - | $42,399 | 45 | $80,037 | Nov 26 | UTV Motion Pictures | false |
| 48 | Sea Monsters: A Prehistoric Adventure | - | - | - | $41,369 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 49 | Dolphins and Whales 3D: Tribes of the Ocean | - | - | - | $39,281 | 42 | $7,714,996 | Feb 15 | 3D Entertainment | false |
| 50 | RocknRolla | - | - | - | $38,163 | 826 | $5,700,626 | Oct 8 | Warner Bros. | false |
| 51 | Magnificent Desolation: Walking on the Moon | - | - | - | $33,975 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 52 | Nights in Rodanthe | - | - | - | $31,490 | 2,704 | $41,850,659 | Sep 26 | Warner Bros. | false |
| 53 | Fly Me to the Moon 3D | - | - | - | $29,869 | 713 | $13,816,982 | Aug 15 | Summit Entertainment | false |
| 54 | Space Station 3D | - | - | - | $28,104 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 55 | Journey to the Center of the Earth | - | - | - | $20,551 | 2,830 | $101,704,370 | Jul 11 | Warner Bros. | false |
| 56 | Noah's Arc: Jumping the Broom | - | - | - | $20,135 | 9 | $532,878 | Oct 24 | Logo | false |
| 57 | The Secrets | - | - | - | $19,536 | 9 | $122,094 | Nov 26 | Monterey Media | false |
| 58 | What Just Happened | - | - | - | $15,234 | 88 | $1,090,947 | Oct 17 | Magnolia Pictures | false |
| 59 | My Name Is Bruce | - | - | - | $13,284 | 4 | $173,066 | Oct 31 | Image Entertainment | false |
| 60 | A Secret | - | - | - | $13,065 | 11 | $623,558 | Sep 5 | Strand Releasing | false |
| 61 | Man on Wire | - | - | - | $12,366 | 93 | $2,962,242 | Jul 25 | Magnolia Pictures | false |
| 62 | Pride and Glory | - | - | - | $12,333 | 2,585 | $15,740,721 | Oct 24 | Warner Bros. | false |
| 63 | I Served the King of England | - | - | - | $12,051 | 38 | $617,403 | Aug 29 | Sony Pictures Classics | false |
| 64 | Sex Drive | - | - | - | $11,898 | 2,421 | $8,402,485 | Oct 17 | Summit Entertainment | false |
| 65 | Harvard Beats Yale 29-29 | - | - | - | $10,941 | 13 | $268,431 | Nov 19 | Kino International | false |
| 66 | Repo! The Genetic Opera | - | - | - | $10,862 | 11 | $146,750 | Nov 7 | Lionsgate | false |
| 67 | Roving Mars | - | - | - | $8,649 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 68 | Tell No One | - | - | - | $7,931 | 112 | $6,177,192 | Jul 2 | Music Box Films | false |
| 69 | Were the World Mine | - | - | - | $7,714 | 4 | $123,789 | Oct 31 | SPEAK Productions | false |
| 70 | I Can't Think Straight | - | - | - | $6,632 | 3 | $39,576 | Nov 21 | Regent Releasing | false |
| 71 | How to Lose Friends & Alienate People | - | - | - | $5,479 | 1,750 | $2,778,752 | Oct 3 | Metro-Goldwyn-Mayer (MGM) | false |
| 72 | U2 3D | - | - | - | $5,382 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 73 | A Girl Cut in Two | - | - | - | $4,977 | 21 | $409,658 | Aug 15 | IFC Films | false |
| 74 | Ashes of Time | - | - | - | $4,478 | 18 | $174,273 | Oct 10 | Sony Pictures Classics | false |
| 75 | Familiar Strangers | - | - | - | $3,949 | 4 | $34,068 | Nov 14 | Cavalier Films | false |
| 76 | How About You | - | - | - | $3,937 | 7 | $78,234 | Nov 14 | Strand Releasing | false |
| 77 | Hounddog | - | - | - | $3,825 | 11 | $131,961 | Sep 19 | Empire Pictures Inc. | false |
| 78 | The Dukes | - | - | - | $3,698 | 11 | $26,875 | Nov 14 | Cavu Pictures | false |
| 79 | Fear(s) of the Dark | - | - | - | $3,241 | 8 | $77,876 | Oct 22 | IFC Films | false |
| 80 | Frozen River | - | - | - | $3,189 | 96 | $2,511,476 | Aug 1 | Sony Pictures Classics | false |
| 81 | I.O.U.S.A. | - | - | - | $3,108 | 358 | $821,046 | Aug 22 | Roadside Attractions | false |
| 82 | Sky Kids | - | - | - | $3,075 | 17 | $144,680 | Aug 15 | Dark Coast Pictures | false |
| 83 | Haunted Castle | - | - | - | $3,029 | 10 | $13,651,656 | Feb 23 | nWave Pictures | false |
| 84 | Ballast | - | - | - | $3,022 | 5 | $77,556 | Oct 1 | Alluvial Film Company | false |
| 85 | Antarctica | - | - | - | $2,863 | 2 | $21,679 | Aug 29 | Regent Releasing | false |
| 86 | Louise Bourgeois | - | - | - | $2,684 | 4 | $95,865 | Jun 25 | Zeitgeist Films | false |
| 87 | The Betrayal | - | - | - | $2,554 | 3 | $41,271 | Nov 21 | The Cinema Guild | false |
| 88 | Pray the Devil Back to Hell | - | - | - | $2,137 | 5 | $90,066 | Nov 7 | Balcony Releasing | false |
| 89 | Special 2008 Re-release | - | - | - | $1,875 | 1 | $7,202 | Nov 21 | Magnolia Pictures | false |
| 90 | Stranded | - | - | - | $1,843 | 7 | $89,473 | Oct 22 | Zeitgeist Films | false |
| 91 | Trouble the Water | - | - | - | $1,816 | 15 | $520,151 | Aug 22 | Zeitgeist Films | false |
| 92 | The Alphabet Killer | - | - | - | $1,434 | 2 | $29,784 | Nov 7 | Anchor Bay Films | false |
| 93 | The Matador | - | - | - | $1,371 | 2 | $21,816 | Oct 31 | City Lights Pictures | false |
| 94 | The Wild Child | - | - | - | $1,212 | 2 | $65,051 | Nov 7 | The Film Desk | false |
| 95 | The First Basket | - | - | - | $1,169 | 4 | $20,440 | Oct 29 | Laemmle/Zeller Films | false |
| 96 | Breakfast with Scot | - | - | - | $1,113 | 6 | $46,060 | Oct 10 | Regent Releasing | false |
| 97 | Flow: For Love of Water | - | - | - | $1,100 | 11 | $142,569 | Mar 21 | Oscilloscope | false |
| 98 | One Day You'll Understand | - | - | - | $1,085 | 7 | $145,642 | Oct 31 | Kino International | false |
| 99 | Otto; or, Up with Dead People | - | - | - | $940 | 2 | $11,295 | Nov 7 | Strand Releasing | false |
| 100 | Lake City | - | - | - | $858 | 2 | $12,767 | Nov 21 | Screen Media Films | false |
| 101 | House | - | - | - | $642 | 363 | $575,048 | Nov 7 | Roadside Attractions | false |
| 102 | Monsieur Verdoux | - | - | - | $581 | 2 | $64,636 | Mar 14 | The Film Desk | false |
| 103 | The Other End of the Line | - | - | - | $577 | 91 | $115,592 | Oct 31 | Metro-Goldwyn-Mayer (MGM) | false |
| 104 | Rome & Jewel | - | - | - | $470 | 1 | $470 | Nov 28 | Emerging Pictures | false |
| 105 | The Pool | - | - | - | $148 | 8 | $95,102 | Sep 3 | Vitagraph Films | false |
