| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Valentine's Day | - | - | - | $63,135,312 | 3,665 | $110,485,654 | Feb 12 | Warner Bros. | false |
| 2 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $38,661,634 | 3,396 | $88,768,303 | Feb 12 | Twentieth Century Fox | false |
| 3 | The Wolfman | - | - | - | $35,555,065 | 3,223 | $61,979,680 | Feb 12 | Universal Pictures | false |
| 4 | Avatar | - | - | - | $28,782,849 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 5 | Dear John | - | - | - | $18,200,188 | 3,062 | $80,014,842 | Feb 5 | Screen Gems | false |
| 6 | Tooth Fairy | - | - | - | $8,005,767 | 3,345 | $60,022,256 | Jan 22 | Twentieth Century Fox | false |
| 7 | From Paris with Love | - | - | - | $6,352,780 | 2,722 | $24,077,427 | Feb 5 | Lionsgate | false |
| 8 | Edge of Darkness | - | - | - | $5,570,476 | 3,066 | $43,313,890 | Jan 29 | Warner Bros. | false |
| 9 | Crazy Heart | - | - | - | $4,982,062 | 1,361 | $39,464,306 | Dec 16 | Fox Searchlight Pictures | false |
| 10 | When in Rome | - | - | - | $4,277,925 | 2,456 | $32,680,633 | Jan 29 | Walt Disney Studios Motion Pictures | false |
| 11 | The Book of Eli | - | - | - | $4,211,221 | 3,111 | $94,835,059 | Jan 15 | Warner Bros. | false |
| 12 | The Blind Side | - | - | - | $2,667,208 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 13 | My Name Is Khan | - | - | - | $2,264,983 | 125 | $4,018,771 | Feb 12 | Fox Searchlight Pictures | false |
| 14 | Legion | - | - | - | $2,104,565 | 2,476 | $40,168,080 | Jan 22 | Screen Gems | false |
| 15 | Up in the Air | - | - | - | $2,063,060 | 2,218 | $83,823,381 | Dec 4 | Paramount Pictures | false |
| 16 | Sherlock Holmes | - | - | - | $1,887,397 | 3,626 | $209,028,679 | Dec 25 | Warner Bros. | false |
| 17 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $1,696,335 | 3,747 | $219,614,612 | Dec 23 | Twentieth Century Fox | false |
| 18 | It's Complicated | - | - | - | $1,396,925 | 2,955 | $112,735,375 | Dec 25 | Universal Pictures | false |
| 19 | The Princess and the Frog | - | - | - | $811,714 | 3,475 | $104,400,899 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 20 | The Lovely Bones | - | - | - | $804,802 | 2,638 | $44,114,232 | Dec 11 | DreamWorks | false |
| 21 | The Twilight Saga: New Moon | - | - | - | $688,386 | 4,124 | $296,623,634 | Nov 20 | Summit Entertainment | false |
| 22 | The Last Station | - | - | - | $606,699 | 354 | $6,617,867 | Jan 15 | Sony Pictures Classics | false |
| 23 | An Education | - | - | - | $583,342 | 763 | $12,574,914 | Oct 9 | Sony Pictures Classics | false |
| 24 | The Spy Next Door | - | - | - | $576,642 | 2,924 | $24,307,086 | Jan 15 | Lionsgate | false |
| 25 | A Single Man | - | - | - | $574,452 | 354 | $9,176,000 | Dec 11 | The Weinstein Company | false |
| 26 | The Young Victoria | - | - | - | $366,862 | 476 | $11,001,272 | Dec 18 | Apparition | false |
| 27 | Planet 51 | - | - | - | $266,576 | 3,035 | $42,194,060 | Nov 20 | Sony Pictures Releasing | false |
| 28 | Precious | - | - | - | $261,563 | 1,003 | $47,566,524 | Nov 6 | Lionsgate | false |
| 29 | The Imaginarium of Doctor Parnassus | - | - | - | $206,000 | 607 | $7,689,607 | Dec 25 | Sony Pictures Classics | false |
| 30 | The White Ribbon | - | - | - | $195,930 | 106 | $2,222,862 | Dec 30 | Sony Pictures Classics | false |
| 31 | Leap Year | - | - | - | $162,110 | 2,512 | $25,918,920 | Jan 8 | Universal Pictures | false |
| 32 | Under the Sea 3D | - | - | - | $159,814 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 33 | 2012 | - | - | - | $149,288 | 3,444 | $166,112,167 | Nov 13 | Sony Pictures Releasing | false |
| 34 | Invictus | - | - | - | $145,474 | 2,170 | $37,491,364 | Dec 11 | Warner Bros. | false |
| 35 | Fantastic Mr. Fox | - | - | - | $115,775 | 2,304 | $21,002,919 | Nov 13 | Twentieth Century Fox | false |
| 36 | Broken Embraces | - | - | - | $115,147 | 202 | $5,014,305 | Nov 20 | Sony Pictures Classics | false |
| 37 | To Save a Life | - | - | - | $73,469 | 441 | $3,777,210 | Jan 22 | The Samuel Goldwyn Company | false |
| 38 | Old Dogs | - | - | - | $57,823 | 3,425 | $49,492,060 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 39 | Nine | - | - | - | $52,300 | 1,412 | $19,676,965 | Dec 18 | The Weinstein Company | false |
| 40 | Ajami | - | - | - | $48,683 | 23 | $622,403 | Feb 3 | Kino International | false |
| 41 | North Face | - | - | - | $45,686 | 36 | $711,421 | Jan 29 | Music Box Films | false |
| 42 | The Messenger | - | - | - | $43,715 | 50 | $1,109,660 | Nov 13 | Oscilloscope | false |
| 43 | Preacher's Kid | - | - | - | $36,072 | 109 | $515,065 | Jan 29 | 8x Entertainment | false |
| 44 | Youth in Revolt | - | - | - | $32,785 | 1,873 | $15,281,286 | Jan 8 | Dimension Films | false |
| 45 | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | - | - | - | $31,420 | 12 | $453,993 | Jan 29 | First Run | false |
| 46 | Saint John of Las Vegas | - | - | - | $28,338 | 14 | $102,645 | Jan 29 | IndieVest Pictures | false |
| 47 | 3 Idiots | - | - | - | $28,189 | 156 | $6,532,874 | Dec 23 | Reliance Big Pictures | false |
| 48 | Terribly Happy | - | - | - | $27,719 | 9 | $170,943 | Feb 5 | Oscilloscope | false |
| 49 | Fish Tank | - | - | - | $25,721 | 15 | $374,675 | Jan 15 | IFC Films | false |
| 50 | Creation | - | - | - | $25,300 | 12 | $341,323 | Jan 22 | Newmarket Films | false |
| 51 | The Road | - | - | - | $22,769 | 396 | $8,117,000 | Nov 25 | Dimension Films | false |
| 52 | Frozen | - | - | - | $20,733 | 106 | $246,176 | Feb 5 | Anchor Bay Films | false |
| 53 | Me and Orson Welles | - | - | - | $20,319 | 134 | $1,190,003 | Nov 25 | Freestyle Releasing | false |
| 54 | Red Riding: The Year of Our Lord 1974 | - | - | - | $17,056 | 9 | $151,644 | Feb 5 | IFC Films | false |
| 55 | That Evening Sun | - | - | - | $15,789 | 10 | $281,350 | Nov 6 | Freestyle Releasing | false |
| 56 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $14,697 | 96 | $1,702,112 | Nov 20 | First Look International | false |
| 57 | Ran 2010 Re-release | - | - | - | $13,470 | 4 | $124,673 | Feb 5 | Rialto Pictures | false |
| 58 | The Boondock Saints II: All Saints Day | - | - | - | $10,614 | 524 | $10,273,188 | Oct 30 | Apparition | false |
| 59 | Videocracy | - | - | - | $10,491 | 1 | $23,720 | Feb 12 | Kino International | false |
| 60 | The Private Lives of Pippa Lee | - | - | - | $8,346 | 26 | $337,356 | Nov 27 | Screen Media Films | false |
| 61 | The Korean | - | - | - | $6,450 | 2 | $20,279 | Feb 5 | Indican Pictures | false |
| 62 | A Town Called Panic | - | - | - | $6,208 | 10 | $165,509 | Dec 16 | Zeitgeist Films | false |
| 63 | The Girl on the Train | - | - | - | $5,613 | 10 | $208,023 | Jan 22 | Strand Releasing | false |
| 64 | Dolphins and Whales 3D: Tribes of the Ocean | - | - | - | $5,314 | 42 | $7,714,996 | Feb 15 | 3D Entertainment | false |
| 65 | District 13: Ultimatum | - | - | - | $4,710 | 9 | $36,136 | Feb 5 | Magnolia Pictures | false |
| 66 | Shanghai Red 2010 Re-release | - | - | - | $4,299 | 3 | $30,353 | Feb 12 | Indican Pictures | false |
| 67 | 44 Inch Chest 2010 Re-release | - | - | - | $3,470 | 5 | $39,033 | Jan 15 | Image Entertainment | false |
| 68 | House | - | - | - | $3,253 | 7 | $209,765 | Jan 15 | Janus Films | false |
| 69 | 35 Shots of Rum | - | - | - | $3,037 | 5 | $177,511 | Sep 16 | The Cinema Guild | false |
| 70 | Red Cliff | - | - | - | $2,154 | 42 | $627,047 | Nov 18 | Magnolia Pictures | false |
| 71 | The Weathered Underground | - | - | - | $2,012 | 22 | $140,091 | Jan 26 | Indican Pictures | false |
| 72 | Four Seasons Lodge | - | - | - | $1,977 | 3 | $58,334 | Nov 11 | First Run | false |
| 73 | The Beaches of Agnès | - | - | - | $1,879 | 7 | $239,711 | Jul 2 | The Cinema Guild | false |
| 74 | Seraphine | - | - | - | $1,850 | 24 | $884,613 | Jun 5 | Music Box Films | false |
| 75 | Killing Kasztner | - | - | - | $1,603 | 5 | $112,313 | Oct 23 | Sky Island Films | false |
| 76 | Beeswax | - | - | - | $1,458 | 3 | $46,590 | Aug 7 | The Cinema Guild | false |
| 77 | The Maid | - | - | - | $1,458 | 19 | $576,608 | Oct 16 | Elephant Eye Films | false |
| 78 | The Sun 2009 Re-release | - | - | - | $1,019 | 4 | $77,303 | Nov 18 | Lorber Films | false |
| 79 | Mississippi Mermaid | - | - | - | $763 | 1 | $33,216 | Jul 10 | The Film Desk | false |
| 80 | The Cove | - | - | - | $700 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
| 81 | The Headless Woman | - | - | - | $640 | 3 | $100,177 | Aug 19 | Strand Releasing | false |
| 82 | Good Hair | - | - | - | $580 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
| 83 | The September Issue | - | - | - | $477 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 84 | Yuri Gagarin Conspiracy: Fallen Idol | - | - | - | $456 | 2 | $14,471 | Oct 2 | Indican Pictures | false |
| 85 | Waiting for Armageddon | - | - | - | $453 | 1 | $10,501 | Jan 8 | First Run | false |
| 86 | Sweetgrass | - | - | - | $361 | 9 | $207,473 | Jan 6 | The Cinema Guild | false |
| 87 | Shall We Kiss? | - | - | - | $273 | 33 | $535,499 | Mar 27 | Music Box Films | false |
