| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Coraline | - | - | - | $4,068,478 | 2,320 | $75,286,229 | Feb 6 | Focus Features | false |
| 2 | Friday the 13th | - | - | - | $3,015,084 | 3,105 | $65,002,019 | Feb 13 | Warner Bros. | false |
| 3 | Taken | - | - | - | $2,836,545 | 3,184 | $145,000,989 | Jan 30 | Twentieth Century Fox | false |
| 4 | He's Just Not That Into You | - | - | - | $2,811,024 | 3,175 | $93,953,653 | Feb 6 | Warner Bros. | false |
| 5 | Confessions of a Shopaholic | - | - | - | $2,742,693 | 2,534 | $44,277,350 | Feb 13 | Walt Disney Studios Motion Pictures | false |
| 6 | Paul Blart: Mall Cop | - | - | - | $2,590,705 | 3,206 | $146,336,178 | Jan 16 | Sony Pictures Releasing | false |
| 7 | The Pink Panther 2 | - | - | - | $2,254,248 | 3,245 | $35,922,978 | Feb 6 | Sony Pictures Releasing | false |
| 8 | Hotel for Dogs | - | - | - | $1,765,476 | 3,271 | $73,034,460 | Jan 16 | DreamWorks | false |
| 9 | Slumdog Millionaire | - | - | - | $1,421,140 | 2,943 | $141,319,928 | Nov 12 | - | false |
| 10 | The International | - | - | - | $1,370,874 | 2,364 | $25,450,527 | Feb 13 | Sony Pictures Releasing | false |
| 11 | Push | - | - | - | $1,119,344 | 2,313 | $31,811,527 | Feb 6 | Summit Entertainment | false |
| 12 | Gran Torino | - | - | - | $955,382 | 3,045 | $148,095,302 | Dec 12 | Warner Bros. | false |
| 13 | The Uninvited | - | - | - | $476,328 | 2,344 | $28,596,818 | Jan 30 | DreamWorks | false |
| 14 | The Reader | - | - | - | $461,757 | 1,203 | $34,194,407 | Dec 10 | The Weinstein Company | false |
| 15 | The Wrestler | - | - | - | $399,534 | 776 | $26,238,243 | Dec 17 | - | false |
| 16 | Underworld: Rise of the Lycans | - | - | - | $361,409 | 2,942 | $45,802,315 | Jan 23 | Screen Gems | false |
| 17 | The Curious Case of Benjamin Button | - | - | - | $317,151 | 2,988 | $127,509,326 | Dec 25 | Paramount Pictures | false |
| 18 | Under the Sea 3D | - | - | - | $257,910 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 19 | Milk | - | - | - | $205,723 | 882 | $31,841,299 | Nov 26 | Focus Features | false |
| 20 | Revolutionary Road | - | - | - | $202,678 | 1,077 | $22,911,480 | Dec 26 | Paramount Vantage | false |
| 21 | New in Town | - | - | - | $197,368 | 1,941 | $16,734,283 | Jan 30 | Lionsgate Films | false |
| 22 | Inkheart | - | - | - | $173,478 | 2,655 | $17,303,424 | Jan 23 | Warner Bros. | false |
| 23 | Doubt | - | - | - | $149,127 | 1,287 | $33,446,470 | Dec 12 | Miramax | false |
| 24 | Defiance | - | - | - | $145,836 | 1,793 | $28,644,813 | Dec 31 | Paramount Vantage | false |
| 25 | My Bloody Valentine | - | - | - | $138,956 | 2,534 | $51,545,952 | Jan 16 | Lionsgate Films | false |
| 26 | Twilight | - | - | - | $137,909 | 3,649 | $192,769,854 | Nov 21 | Summit Entertainment | false |
| 27 | Frost/Nixon | - | - | - | $129,600 | 1,105 | $18,622,031 | Dec 5 | Universal Pictures | false |
| 28 | Bolt | - | - | - | $116,467 | 3,654 | $114,053,579 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 29 | Bride Wars | - | - | - | $96,926 | 3,228 | $58,715,510 | Jan 9 | Twentieth Century Fox | false |
| 30 | Marley & Me | - | - | - | $80,310 | 3,505 | $143,153,751 | Dec 25 | Twentieth Century Fox | false |
| 31 | The Tale of Despereaux | - | - | - | $62,475 | 3,107 | $50,877,145 | Dec 19 | Universal Pictures | false |
| 32 | Last Chance Harvey | - | - | - | $61,251 | 1,108 | $14,889,042 | Dec 25 | Overture Films | false |
| 33 | Bedtime Stories | - | - | - | $59,546 | 3,684 | $110,101,975 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 34 | Yes Man | - | - | - | $54,513 | 3,434 | $97,690,976 | Dec 19 | Warner Bros. | false |
| 35 | Madagascar: Escape 2 Africa | - | - | - | $42,753 | 4,065 | $180,010,950 | Nov 7 | DreamWorks | false |
| 36 | Notorious | - | - | - | $34,996 | 1,641 | $36,843,682 | Jan 16 | - | false |
| 37 | Valkyrie | - | - | - | $27,137 | 2,838 | $83,077,833 | Dec 25 | United Artists | false |
| 38 | The Day the Earth Stood Still | - | - | - | $17,929 | 3,560 | $79,366,978 | Dec 12 | Twentieth Century Fox | false |
| 39 | The Dark Knight | - | - | - | $17,865 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 40 | The Unborn | - | - | - | $17,700 | 2,359 | $42,670,410 | Jan 9 | Universal Pictures | false |
| 41 | Fanboys | - | - | - | $16,339 | 45 | $688,529 | Feb 6 | The Weinstein Company | false |
| 42 | Australia | - | - | - | $15,517 | 2,721 | $49,554,002 | Nov 26 | Twentieth Century Fox | false |
| 43 | Deep Sea | - | - | - | $3,203 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 44 | Vicky Cristina Barcelona | - | - | - | $2,943 | 726 | $23,216,709 | Aug 15 | - | false |
| 45 | Luck by Chance | - | - | - | $1,927 | 57 | $356,019 | Jan 30 | Adlabs Films | false |
| 46 | Outlander | - | - | - | $1,634 | 81 | $166,003 | Jan 23 | Third Rail Releasing | false |
| 47 | Crips and Bloods: Made in America | - | - | - | $1,030 | 4 | $70,219 | Jan 23 | Argot Pictures | false |
| 48 | Made in U.S.A | - | - | - | $993 | 2 | $95,209 | Jan 9 | Rialto Pictures | false |
| 49 | Were the World Mine | - | - | - | $929 | 4 | $123,789 | Oct 31 | - | false |
| 50 | I.O.U.S.A. | - | - | - | $167 | 358 | $821,046 | Aug 22 | Roadside Attractions | false |
| 51 | Lola Montès | - | - | - | $73 | 4 | $120,306 | Oct 10 | Rialto Pictures | false |
