| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Ghost Rider | - | - | - | $6,634,072 | 3,620 | $115,802,596 | Feb 16 | Sony Pictures Releasing | false |
| 2 | Bridge to Terabithia | - | - | - | $5,972,105 | 3,210 | $82,272,442 | Feb 16 | Walt Disney Studios Motion Pictures | false |
| 3 | Norbit | - | - | - | $3,153,831 | 3,145 | $95,673,607 | Feb 9 | DreamWorks | false |
| 4 | Music and Lyrics | - | - | - | $2,251,841 | 2,955 | $50,572,589 | Feb 14 | Warner Bros. | false |
| 5 | Daddy's Little Girls | - | - | - | $1,853,321 | 2,111 | $31,366,978 | Feb 14 | Lionsgate | false |
| 6 | Breach | - | - | - | $1,756,845 | 1,505 | $33,231,264 | Feb 16 | Universal Pictures | false |
| 7 | Night at the Museum | - | - | - | $1,162,209 | 3,768 | $250,863,268 | Dec 22 | Twentieth Century Fox | false |
| 8 | Because I Said So | - | - | - | $953,940 | 2,529 | $42,674,040 | Feb 2 | Universal Pictures | false |
| 9 | Hannibal Rising | - | - | - | $837,458 | 3,003 | $27,670,986 | Feb 9 | Metro-Goldwyn-Mayer (MGM) | false |
| 10 | The Messengers | - | - | - | $578,257 | 2,529 | $35,374,833 | Feb 2 | Screen Gems | false |
| 11 | Pan's Labyrinth | - | - | - | $424,845 | 1,143 | $37,634,615 | Dec 29 | Picturehouse | false |
| 12 | Dreamgirls | - | - | - | $376,342 | 2,797 | $103,365,956 | Dec 15 | DreamWorks | false |
| 13 | The Queen | - | - | - | $293,940 | 1,850 | $56,441,711 | Sep 30 | Miramax | false |
| 14 | Epic Movie | - | - | - | $285,370 | 2,840 | $39,739,367 | Jan 26 | Twentieth Century Fox | false |
| 15 | Smokin' Aces | - | - | - | $282,285 | 2,219 | $35,787,686 | Jan 26 | Universal Pictures | false |
| 16 | Letters from Iwo Jima | - | - | - | $249,807 | 781 | $13,756,082 | Dec 20 | Warner Bros. | false |
| 17 | The Last King of Scotland | - | - | - | $203,129 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 18 | Notes on a Scandal | - | - | - | $178,714 | 682 | $17,510,118 | Dec 25 | Fox Searchlight Pictures | false |
| 19 | The Pursuit of Happyness | - | - | - | $150,425 | 3,169 | $163,566,459 | Dec 15 | Sony Pictures Releasing | false |
| 20 | Charlotte's Web | - | - | - | $121,569 | 3,745 | $82,985,708 | Dec 15 | Paramount Pictures | false |
| 21 | Happy Feet | - | - | - | $120,421 | 3,804 | $198,000,317 | Nov 17 | Warner Bros. | false |
| 22 | Babel | - | - | - | $116,716 | 1,251 | $34,302,837 | Oct 27 | Paramount Vantage | false |
| 23 | Factory Girl | - | - | - | $115,545 | 336 | $1,675,241 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 24 | Stomp the Yard | - | - | - | $102,408 | 2,169 | $61,356,221 | Jan 12 | Screen Gems | false |
| 25 | Blood Diamond | - | - | - | $81,419 | 1,920 | $57,377,916 | Dec 8 | Warner Bros. | false |
| 26 | Arthur and the Invisibles | - | - | - | $73,188 | 2,248 | $15,132,763 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 27 | Children of Men | - | - | - | $71,395 | 1,524 | $35,552,383 | Dec 25 | Universal Pictures | false |
| 28 | The Painted Veil | - | - | - | $62,756 | 287 | $8,060,487 | Dec 20 | Warner Independent Pictures (WIP) | false |
| 29 | The Departed | - | - | - | $60,127 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 30 | Casino Royale | - | - | - | $55,455 | 3,443 | $167,445,960 | Nov 17 | Sony Pictures Releasing | false |
| 31 | Deep Sea | - | - | - | $53,079 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 32 | Eragon | - | - | - | $51,881 | 3,030 | $75,030,163 | Dec 15 | Twentieth Century Fox | false |
| 33 | Flushed Away | - | - | - | $50,073 | 3,707 | $64,665,672 | Nov 3 | DreamWorks | false |
| 34 | Catch and Release | - | - | - | $48,573 | 1,622 | $15,539,051 | Jan 26 | Sony Pictures Releasing | false |
| 35 | Rocky Balboa | - | - | - | $33,047 | 3,019 | $70,270,943 | Dec 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 36 | Freedom Writers | - | - | - | $32,103 | 2,286 | $36,605,602 | Jan 5 | Paramount Pictures | false |
| 37 | We Are Marshall | - | - | - | $29,916 | 2,606 | $43,545,364 | Dec 22 | Warner Bros. | false |
| 38 | Unaccompanied Minors | - | - | - | $22,834 | 2,775 | $16,655,224 | Dec 8 | Warner Bros. | false |
| 39 | Breaking and Entering | - | - | - | $18,096 | 95 | $930,469 | Dec 15 | The Weinstein Company | false |
| 40 | Borat | - | - | - | $10,422 | 2,611 | $128,505,958 | Nov 3 | Twentieth Century Fox | false |
| 41 | The Good Shepherd | - | - | - | $7,995 | 2,250 | $59,952,835 | Dec 22 | Universal Pictures | false |
| 42 | Alpha Dog | - | - | - | $6,555 | 1,292 | $15,309,602 | Jan 12 | Universal Pictures | false |
| 43 | Days of Glory | - | - | - | $6,082 | 29 | $320,700 | Dec 6 | The Weinstein Company | false |
| 44 | Little Miss Sunshine | - | - | - | $4,815 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 45 | Perfume: The Story of a Murderer | - | - | - | $4,605 | 280 | $2,223,293 | Dec 27 | DreamWorks | false |
| 46 | The Good German | - | - | - | $3,989 | 66 | $1,308,696 | Dec 15 | Warner Bros. | false |
| 47 | Blood and Chocolate | - | - | - | $1,970 | 1,200 | $3,526,847 | Jan 26 | Metro-Goldwyn-Mayer (MGM) | false |
| 48 | Miss Potter | - | - | - | $1,647 | 102 | $3,005,605 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 49 | The History Boys | - | - | - | $1,032 | 165 | $2,706,659 | Nov 21 | Fox Searchlight Pictures | false |
