| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $48,231,531 | 3,768 | $250,863,268 | Dec 22 | Twentieth Century Fox | false |
| 2 | The Pursuit of Happyness | - | - | - | $25,461,188 | 3,169 | $163,566,459 | Dec 15 | Sony Pictures Releasing | false |
| 3 | Dreamgirls | - | - | - | $18,384,211 | 2,797 | $103,365,956 | Dec 15 | DreamWorks | false |
| 4 | Charlotte's Web | - | - | - | $14,942,318 | 3,745 | $82,985,708 | Dec 15 | Paramount Pictures | false |
| 5 | The Good Shepherd | - | - | - | $14,239,635 | 2,250 | $59,952,835 | Dec 22 | Universal Pictures | false |
| 6 | Rocky Balboa | - | - | - | $13,779,192 | 3,019 | $70,270,943 | Dec 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 7 | Eragon | - | - | - | $10,843,779 | 3,030 | $75,030,163 | Dec 15 | Twentieth Century Fox | false |
| 8 | We Are Marshall | - | - | - | $10,433,431 | 2,606 | $43,545,364 | Dec 22 | Warner Bros. | false |
| 9 | Happy Feet | - | - | - | $10,008,451 | 3,804 | $198,000,317 | Nov 17 | Warner Bros. | false |
| 10 | The Holiday | - | - | - | $8,837,796 | 2,698 | $63,224,849 | Dec 8 | Sony Pictures Releasing | false |
| 11 | Blood Diamond | - | - | - | $6,764,435 | 1,920 | $57,377,916 | Dec 8 | Warner Bros. | false |
| 12 | Casino Royale | - | - | - | $6,014,342 | 3,443 | $167,445,960 | Nov 17 | Sony Pictures Releasing | false |
| 13 | Black Christmas | - | - | - | $4,936,744 | 1,544 | $16,273,581 | Dec 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 14 | Apocalypto | - | - | - | $4,625,899 | 2,465 | $50,866,635 | Dec 8 | Walt Disney Studios Motion Pictures | false |
| 15 | The Nativity Story | - | - | - | $1,956,785 | 3,083 | $37,629,831 | Dec 1 | New Line Cinema | false |
| 16 | Unaccompanied Minors | - | - | - | $1,281,456 | 2,775 | $16,655,224 | Dec 8 | Warner Bros. | false |
| 17 | The Queen | - | - | - | $1,271,000 | 1,850 | $56,441,711 | Sep 30 | Miramax | false |
| 18 | Deja Vu | - | - | - | $1,053,984 | 3,108 | $64,038,616 | Nov 22 | Walt Disney Studios Motion Pictures | false |
| 19 | Volver | - | - | - | $829,774 | 689 | $12,899,867 | Nov 3 | Sony Pictures Classics | false |
| 20 | Pan's Labyrinth | - | - | - | $779,427 | 1,143 | $37,634,615 | Dec 29 | Picturehouse | false |
| 21 | Borat | - | - | - | $758,919 | 2,611 | $128,505,958 | Nov 3 | Twentieth Century Fox | false |
| 22 | Children of Men | - | - | - | $702,982 | 1,524 | $35,552,383 | Dec 25 | Universal Pictures | false |
| 23 | Babel | - | - | - | $658,466 | 1,251 | $34,302,837 | Oct 27 | Paramount Vantage | false |
| 24 | Curse of the Golden Flower | - | - | - | $620,322 | 1,234 | $6,566,773 | Dec 21 | Sony Pictures Classics | false |
| 25 | The Santa Clause 3: The Escape Clause | - | - | - | $613,609 | 3,458 | $84,500,122 | Nov 3 | Walt Disney Studios Motion Pictures | false |
| 26 | Notes on a Scandal | - | - | - | $559,111 | 682 | $17,510,118 | Dec 25 | Fox Searchlight Pictures | false |
| 27 | The Painted Veil | - | - | - | $491,185 | 287 | $8,060,487 | Dec 20 | Warner Independent Pictures (WIP) | false |
| 28 | The History Boys | - | - | - | $478,818 | 165 | $2,706,659 | Nov 21 | Fox Searchlight Pictures | false |
| 29 | The Departed | - | - | - | $459,463 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 30 | Deck the Halls | - | - | - | $338,979 | 3,205 | $35,093,569 | Nov 22 | Twentieth Century Fox | false |
| 31 | Little Children | - | - | - | $213,049 | 115 | $5,463,019 | Oct 6 | New Line Cinema | false |
| 32 | The Polar Express 2006 IMAX Release | - | - | - | $204,955 | 37 | $2,940,722 | Nov 17 | Warner Bros. | false |
| 33 | The Prestige | - | - | - | $203,845 | 2,305 | $53,089,891 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 34 | Bhagam Bhag | - | - | - | $180,805 | 51 | $789,963 | Dec 22 | Rainbow Releasing | false |
| 35 | Magnificent Desolation: Walking on the Moon | - | - | - | $162,271 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 36 | The Good German | - | - | - | $158,234 | 66 | $1,308,696 | Dec 15 | Warner Bros. | false |
| 37 | Deep Sea | - | - | - | $139,007 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 38 | Letters from Iwo Jima | - | - | - | $121,204 | 781 | $13,756,082 | Dec 20 | Warner Bros. | false |
| 39 | Sweet Land | - | - | - | $117,002 | 47 | $1,706,325 | Oct 13 | Libero | false |
| 40 | Romeo and Juliet | - | - | - | $113,813 | 73 | $1,386,582 | Dec 15 | Alliance Atlantis Vivafilm | false |
| 41 | Santa vs. the Snowman 3D 2006 Re-release | - | - | - | $71,965 | 29 | $928,275 | Oct 30 | IMAX | false |
| 42 | The Guardian | - | - | - | $66,670 | 3,241 | $55,011,732 | Sep 29 | Walt Disney Studios Motion Pictures | false |
| 43 | Roving Mars | - | - | - | $60,314 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 44 | For Your Consideration | - | - | - | $59,842 | 625 | $5,549,923 | Nov 17 | Warner Independent Pictures (WIP) | false |
| 45 | Perfume: The Story of a Murderer | - | - | - | $55,523 | 280 | $2,223,293 | Dec 27 | DreamWorks | false |
| 46 | Little Miss Sunshine | - | - | - | $55,460 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 47 | Dhoom 2 | - | - | - | $52,904 | 63 | $2,643,586 | Nov 23 | Yash Raj Films | false |
| 48 | Bobby | - | - | - | $50,078 | 1,670 | $11,242,801 | Nov 17 | Metro-Goldwyn-Mayer (MGM) | false |
| 49 | Flicka | - | - | - | $49,141 | 2,877 | $21,000,147 | Oct 20 | Twentieth Century Fox | false |
| 50 | Venus | - | - | - | $45,630 | 168 | $3,347,411 | Dec 21 | Miramax | false |
| 51 | The Work and the Glory III: A House Divided | - | - | - | $35,965 | 44 | $1,325,092 | Nov 22 | Excel Entertainment | false |
| 52 | Facing the Giants | - | - | - | $35,503 | 441 | $10,178,331 | Sep 29 | IDP Distribution | false |
| 53 | The Last King of Scotland | - | - | - | $34,437 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 54 | The Illusionist | - | - | - | $33,743 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 55 | Guadalupe: El Milagro Y El Mensaje | - | - | - | $31,340 | 225 | $848,139 | Dec 8 | Slowhand Cinema Releasing | false |
| 56 | The Wedding Weekend | - | - | - | $26,065 | 84 | $1,232,961 | Oct 27 | The Weinstein Company | false |
| 57 | Kabul Express | - | - | - | $25,574 | 50 | $302,458 | Dec 15 | Yash Raj Films | false |
| 58 | Turistas | - | - | - | $25,200 | 1,572 | $7,027,762 | Dec 1 | Fox Atomic | false |
| 59 | The Marine | - | - | - | $24,953 | 2,545 | $18,844,784 | Oct 13 | Twentieth Century Fox | false |
| 60 | Tenacious D in the Pick of Destiny | - | - | - | $23,353 | 1,919 | $8,334,575 | Nov 22 | New Line Cinema | false |
| 61 | The Fountain | - | - | - | $22,651 | 1,472 | $10,144,010 | Nov 22 | Warner Bros. | false |
| 62 | The Texas Chainsaw Massacre: The Beginning | - | - | - | $16,919 | 2,820 | $39,517,763 | Oct 6 | New Line Cinema | false |
| 63 | Snow Cake | - | - | - | $16,113 | 12 | $26,651 | Apr 27 | IFC Films | false |
| 64 | The Nightmare Before Christmas 2006 3D Release | - | - | - | $15,731 | 168 | $8,700,869 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 65 | Aliens of the Deep | - | - | - | $15,468 | 27 | $8,968,684 | Jan 28 | Walt Disney Studios Motion Pictures | false |
| 66 | A Good Year | - | - | - | $13,508 | 2,067 | $7,459,300 | Nov 10 | Twentieth Century Fox | false |
| 67 | Miss Potter | - | - | - | $13,205 | 102 | $3,005,605 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 68 | Copying Beethoven | - | - | - | $12,267 | 29 | $384,029 | Nov 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 69 | Galapagos | - | - | - | $11,618 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 70 | Shortbus | - | - | - | $11,261 | 70 | $1,985,292 | Oct 4 | THINKFilm | false |
| 71 | Army of Shadows | - | - | - | $11,124 | 8 | $741,766 | Apr 28 | Rialto Pictures | false |
| 72 | The Dead Girl | - | - | - | $9,282 | 2 | $19,875 | Dec 29 | First Look International | false |
| 73 | The Rules of the Game | - | - | - | $8,076 | 5 | $273,641 | Oct 27 | Janus Films | false |
| 74 | The Cave of the Yellow Dog | - | - | - | $7,826 | 11 | $141,803 | Nov 10 | Tartan | false |
| 75 | The Young Lieutenant | - | - | - | $6,317 | 3 | $216,724 | Sep 8 | The Cinema Guild | false |
| 76 | Keeping Mum | - | - | - | $5,247 | 79 | $1,619,466 | Sep 15 | THINKFilm | false |
| 77 | The Tiger and the Snow | - | - | - | $5,025 | 4 | $10,167 | Dec 29 | Strand Releasing | false |
| 78 | Van Wilder: The Rise of Taj | - | - | - | $4,768 | 1,979 | $4,300,645 | Dec 1 | Metro-Goldwyn-Mayer (MGM) | false |
| 79 | American Hardcore | - | - | - | $4,660 | 19 | $279,665 | Sep 22 | Sony Pictures Classics | false |
| 80 | Fast Food Nation | - | - | - | $4,580 | 321 | $1,005,539 | Nov 17 | Fox Searchlight Pictures | false |
| 81 | The Case of the Grinning Cat | - | - | - | $4,424 | 1 | $20,944 | Jul 21 | Icarus Films | false |
| 82 | Words of My Perfect Teacher | - | - | - | $4,196 | 3 | $20,318 | Dec 22 | International Film Circuit | false |
| 83 | Flannel Pajamas | - | - | - | $3,948 | 4 | $123,301 | Nov 15 | Gigantic Pictures | false |
| 84 | Driving Lessons | - | - | - | $2,806 | 21 | $239,962 | Oct 13 | Sony Pictures Classics | false |
| 85 | Jesus Camp | - | - | - | $2,789 | 52 | $902,544 | Sep 15 | Magnolia Pictures | false |
| 86 | The Bridge | - | - | - | $2,576 | 19 | $179,780 | Oct 27 | First Stripe Productions | false |
| 87 | Trailer Park Boys: The Movie | - | - | - | $2,356 | 203 | $3,860,678 | Oct 6 | Alliance Atlantis Vivafilm | false |
| 88 | Matthew Barney: No Restraint | - | - | - | $2,136 | 6 | $16,136 | Dec 20 | IFC Films | false |
| 89 | Family Law | - | - | - | $1,499 | 6 | $38,605 | Dec 6 | IFC Films | false |
| 90 | Riding Alone for Thousands of Miles | - | - | - | $1,420 | 13 | $252,325 | Sep 1 | Sony Pictures Classics | false |
| 91 | The Aura | - | - | - | $1,411 | 4 | $58,804 | Nov 15 | IFC Films | false |
| 92 | The PianoTuner of EarthQuakes | - | - | - | $1,347 | 3 | $29,121 | Nov 17 | Zeitgeist Films | false |
| 93 | El Topo | - | - | - | $1,330 | 4 | $80,302 | Dec 13 | ABKCO Films | false |
| 94 | Candy | - | - | - | $1,308 | 12 | $45,128 | Nov 17 | THINKFilm | false |
| 95 | Monkey Warfare | - | - | - | $1,234 | 3 | $36,875 | Dec 8 | Alliance Atlantis Vivafilm | false |
| 96 | Unconscious | - | - | - | $1,165 | 5 | $68,501 | Dec 29 | Regent Releasing | false |
| 97 | The Bridesmaid | - | - | - | $1,041 | 6 | $111,728 | Aug 4 | First Run | false |
| 98 | Broken Sky | - | - | - | $889 | 2 | $29,185 | Sep 29 | Strand Releasing | false |
| 99 | Samoan Wedding | - | - | - | $840 | 3 | $72,244 | Nov 10 | Magnolia Pictures | false |
| 100 | Off the Black | - | - | - | $679 | 4 | $24,425 | Dec 8 | THINKFilm | false |
| 101 | Opal Dream | - | - | - | $425 | 4 | $14,443 | Nov 22 | Strand Releasing | false |
| 102 | The Photographer, His Wife, Her Lover | - | - | - | $313 | 1 | $12,546 | Jul 26 | Icarus Films | false |
