| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $54,401,446 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 2 | The Book of Eli | - | - | - | $38,437,553 | 3,111 | $94,835,059 | Jan 15 | Warner Bros. | false |
| 3 | The Lovely Bones | - | - | - | $19,910,348 | 2,638 | $44,114,232 | Dec 11 | DreamWorks | false |
| 4 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $15,305,808 | 3,747 | $219,614,612 | Dec 23 | Twentieth Century Fox | false |
| 5 | The Spy Next Door | - | - | - | $12,877,043 | 2,924 | $24,307,086 | Jan 15 | Lionsgate | false |
| 6 | Sherlock Holmes | - | - | - | $12,033,507 | 3,626 | $209,028,679 | Dec 25 | Warner Bros. | false |
| 7 | It's Complicated | - | - | - | $9,622,810 | 2,955 | $112,735,375 | Dec 25 | Universal Pictures | false |
| 8 | Leap Year | - | - | - | $7,071,470 | 2,512 | $25,918,920 | Jan 8 | Universal Pictures | false |
| 9 | The Blind Side | - | - | - | $6,972,350 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 10 | Up in the Air | - | - | - | $6,530,101 | 2,218 | $83,823,381 | Dec 4 | Paramount Pictures | false |
| 11 | Daybreakers | - | - | - | $6,132,472 | 2,523 | $30,101,577 | Jan 8 | Lionsgate | false |
| 12 | The Princess and the Frog | - | - | - | $4,004,707 | 3,475 | $104,400,899 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 13 | Youth in Revolt | - | - | - | $3,560,612 | 1,873 | $15,281,286 | Jan 8 | Dimension Films | false |
| 14 | The Imaginarium of Doctor Parnassus | - | - | - | $1,316,438 | 607 | $7,689,607 | Dec 25 | Sony Pictures Classics | false |
| 15 | The Young Victoria | - | - | - | $1,153,976 | 476 | $11,001,272 | Dec 18 | Apparition | false |
| 16 | The Twilight Saga: New Moon | - | - | - | $1,134,419 | 4,124 | $296,623,634 | Nov 20 | Summit Entertainment | false |
| 17 | A Single Man | - | - | - | $996,546 | 354 | $9,176,000 | Dec 11 | The Weinstein Company | false |
| 18 | Invictus | - | - | - | $992,925 | 2,170 | $37,491,364 | Dec 11 | Warner Bros. | false |
| 19 | Crazy Heart | - | - | - | $858,369 | 1,361 | $39,464,306 | Dec 16 | Fox Searchlight Pictures | false |
| 20 | Nine | - | - | - | $724,241 | 1,412 | $19,676,965 | Dec 18 | The Weinstein Company | false |
| 21 | 2012 | - | - | - | $544,017 | 3,444 | $166,112,167 | Nov 13 | Sony Pictures Releasing | false |
| 22 | Planet 51 | - | - | - | $528,853 | 3,035 | $42,194,060 | Nov 20 | Sony Pictures Releasing | false |
| 23 | Broken Embraces | - | - | - | $496,419 | 202 | $5,014,305 | Nov 20 | Sony Pictures Classics | false |
| 24 | Did You Hear About the Morgans? | - | - | - | $463,365 | 2,718 | $29,580,087 | Dec 18 | Sony Pictures Releasing | false |
| 25 | 3 Idiots | - | - | - | $374,515 | 156 | $6,532,874 | Dec 23 | Reliance Big Pictures | false |
| 26 | Precious | - | - | - | $314,016 | 1,003 | $47,566,524 | Nov 6 | Lionsgate | false |
| 27 | Fantastic Mr. Fox | - | - | - | $280,641 | 2,304 | $21,002,919 | Nov 13 | Twentieth Century Fox | false |
| 28 | Old Dogs | - | - | - | $213,770 | 3,425 | $49,492,060 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 29 | An Education | - | - | - | $175,322 | 763 | $12,574,914 | Oct 9 | Sony Pictures Classics | false |
| 30 | Cloudy with a Chance of Meatballs | - | - | - | $173,161 | 3,119 | $124,870,275 | Sep 18 | Sony Pictures Releasing | false |
| 31 | Brothers | - | - | - | $152,353 | 2,088 | $28,544,157 | Dec 4 | Lionsgate | false |
| 32 | Ninja Assassin | - | - | - | $151,998 | 2,503 | $38,122,883 | Nov 25 | Warner Bros. | false |
| 33 | The Road | - | - | - | $150,375 | 396 | $8,117,000 | Nov 25 | Dimension Films | false |
| 34 | The Horse Boy | - | - | - | $147,618 | 5 | $156,612 | Sep 30 | Zeitgeist Films | false |
| 35 | Couples Retreat | - | - | - | $146,185 | 3,074 | $109,204,945 | Oct 9 | Universal Pictures | false |
| 36 | Where the Wild Things Are | - | - | - | $136,007 | 3,735 | $77,233,467 | Oct 16 | Warner Bros. | false |
| 37 | Chance Pe Dance | - | - | - | $130,160 | 68 | $168,643 | Jan 15 | UTV Motion Pictures | false |
| 38 | Under the Sea 3D | - | - | - | $124,965 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 39 | A Christmas Carol | - | - | - | $109,557 | 3,683 | $137,855,863 | Nov 6 | Walt Disney Studios Motion Pictures | false |
| 40 | The White Ribbon | - | - | - | $103,151 | 106 | $2,222,862 | Dec 30 | Sony Pictures Classics | false |
| 41 | The Last Station | - | - | - | $94,093 | 354 | $6,617,867 | Jan 15 | Sony Pictures Classics | false |
| 42 | The Men Who Stare at Goats | - | - | - | $83,091 | 2,453 | $32,428,195 | Nov 6 | Overture Films | false |
| 43 | Law Abiding Citizen | - | - | - | $71,597 | 2,890 | $73,357,727 | Oct 16 | Overture Films | false |
| 44 | The Boondock Saints II: All Saints Day | - | - | - | $36,408 | 524 | $10,273,188 | Oct 30 | Apparition | false |
| 45 | Fish Tank | - | - | - | $32,619 | 15 | $374,675 | Jan 15 | IFC Films | false |
| 46 | Bad Lieutenant: Port of Call New Orleans | - | - | - | $31,180 | 96 | $1,702,112 | Nov 20 | First Look International | false |
| 47 | Me and Orson Welles | - | - | - | $30,836 | 134 | $1,190,003 | Nov 25 | Freestyle Releasing | false |
| 48 | Sea Monsters: A Prehistoric Adventure | - | - | - | $25,777 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 49 | Astro Boy | - | - | - | $20,230 | 3,020 | $19,551,067 | Oct 23 | Summit Entertainment | false |
| 50 | The Secrets of Jonathan Sperry | - | - | - | $17,326 | 135 | $1,355,079 | Sep 18 | Five & Two Pictures | false |
| 51 | House | - | - | - | $16,108 | 7 | $209,765 | Jan 15 | Janus Films | false |
| 52 | The Private Lives of Pippa Lee | - | - | - | $14,166 | 26 | $337,356 | Nov 27 | Screen Media Films | false |
| 53 | The Maid | - | - | - | $12,917 | 19 | $576,608 | Oct 16 | Elephant Eye Films | false |
| 54 | Coco Before Chanel | - | - | - | $10,144 | 307 | $6,113,834 | Sep 25 | Sony Pictures Classics | false |
| 55 | Red Cliff | - | - | - | $7,922 | 42 | $627,047 | Nov 18 | Magnolia Pictures | false |
| 56 | Killing Kasztner | - | - | - | $7,285 | 5 | $112,313 | Oct 23 | Sky Island Films | false |
| 57 | Paranormal Activity | - | - | - | $6,148 | 2,712 | $107,918,810 | Sep 25 | Paramount Pictures | false |
| 58 | 44 Inch Chest 2010 Re-release | - | - | - | $5,187 | 5 | $39,033 | Jan 15 | Image Entertainment | false |
| 59 | Until the Light Takes Us | - | - | - | $5,041 | 3 | $130,441 | Dec 4 | Variance Films | false |
| 60 | The Little Traitor | - | - | - | $3,765 | 5 | $402,088 | Oct 23 | - | false |
| 61 | A Town Called Panic | - | - | - | $3,368 | 10 | $165,509 | Dec 16 | Zeitgeist Films | false |
| 62 | The Missing Person | - | - | - | $2,424 | 3 | $17,896 | Nov 20 | Strand Releasing | false |
| 63 | Wonderful World | - | - | - | $1,923 | 4 | $9,309 | Jan 8 | Magnolia Pictures | false |
| 64 | The Yes Men Fix the World | - | - | - | $1,865 | 16 | $194,533 | Sep 25 | Shadow Distribution | false |
| 65 | Mystery Team | - | - | - | $1,726 | 4 | $89,442 | Aug 28 | Roadside Attractions | false |
| 66 | Four Seasons Lodge | - | - | - | $1,674 | 3 | $58,334 | Nov 11 | First Run | false |
| 67 | Good Hair | - | - | - | $1,591 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
| 68 | Seraphine | - | - | - | $1,521 | 24 | $884,613 | Jun 5 | Music Box Films | false |
| 69 | Cloud 9 | - | - | - | $990 | 8 | $91,675 | Aug 14 | Music Box Films | false |
| 70 | Crude | - | - | - | $861 | 7 | $170,295 | Sep 9 | First Run | false |
| 71 | The Damned United | - | - | - | $811 | 45 | $449,865 | Oct 9 | Sony Pictures Classics | false |
| 72 | The Slammin' Salmon | - | - | - | $660 | 11 | $41,587 | Dec 11 | Anchor Bay Films | false |
| 73 | Bitch Slap | - | - | - | $577 | 3 | $17,365 | Jan 8 | Freestyle Releasing | false |
| 74 | Youssou Ndour: I Bring What I Love | - | - | - | $550 | 7 | $172,225 | Jun 12 | Shadow Distribution | false |
| 75 | $9.99 | - | - | - | $544 | 4 | $52,384 | Dec 12 | Regent Releasing | false |
| 76 | Peter and Vandy | - | - | - | $515 | 3 | $11,495 | Oct 9 | Strand Releasing | false |
| 77 | Le combat dans l'île | - | - | - | $407 | 1 | $50,039 | Jun 12 | The Film Desk | false |
| 78 | That Evening Sun | - | - | - | $393 | 10 | $281,350 | Nov 6 | Freestyle Releasing | false |
| 79 | Waiting for Armageddon | - | - | - | $369 | 1 | $10,501 | Jan 8 | First Run | false |
| 80 | The September Issue | - | - | - | $270 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 81 | The Headless Woman | - | - | - | $236 | 3 | $100,177 | Aug 19 | Strand Releasing | false |
| 82 | Under Our Skin | - | - | - | $175 | 6 | $98,548 | Jun 19 | Shadow Distribution | false |
| 83 | Departures | - | - | - | $156 | 27 | $1,498,210 | May 29 | Regent Releasing | false |
