| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Paul Blart: Mall Cop | - | - | - | $7,401,602 | 3,206 | $146,336,178 | Jan 16 | Sony Pictures Releasing | false |
| 2 | Hotel for Dogs | - | - | - | $5,853,300 | 3,271 | $73,034,460 | Jan 16 | DreamWorks | false |
| 3 | Gran Torino | - | - | - | $3,627,330 | 3,045 | $148,095,302 | Dec 12 | Warner Bros. | false |
| 4 | Notorious | - | - | - | $2,895,876 | 1,641 | $36,843,682 | Jan 16 | Fox Searchlight Pictures | false |
| 5 | My Bloody Valentine | - | - | - | $2,862,506 | 2,534 | $51,545,952 | Jan 16 | Lionsgate | false |
| 6 | Bride Wars | - | - | - | $2,227,174 | 3,228 | $58,715,510 | Jan 9 | Twentieth Century Fox | false |
| 7 | Defiance | - | - | - | $1,598,255 | 1,793 | $28,644,813 | Dec 31 | Paramount Vantage | false |
| 8 | Bedtime Stories | - | - | - | $1,441,989 | 3,684 | $110,101,975 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 9 | Marley & Me | - | - | - | $1,375,793 | 3,505 | $143,153,751 | Dec 25 | Twentieth Century Fox | false |
| 10 | The Unborn | - | - | - | $1,203,090 | 2,359 | $42,670,410 | Jan 9 | Universal Pictures | false |
| 11 | Slumdog Millionaire | - | - | - | $1,172,570 | 2,943 | $141,319,928 | Nov 12 | Fox Searchlight Pictures | false |
| 12 | The Curious Case of Benjamin Button | - | - | - | $1,008,434 | 2,988 | $127,509,326 | Dec 25 | Paramount Pictures | false |
| 13 | Valkyrie | - | - | - | $753,700 | 2,838 | $83,077,833 | Dec 25 | United Artists | false |
| 14 | Last Chance Harvey | - | - | - | $711,791 | 1,108 | $14,889,042 | Dec 25 | Overture Films | false |
| 15 | Yes Man | - | - | - | $490,841 | 3,434 | $97,690,976 | Dec 19 | Warner Bros. | false |
| 16 | Not Easily Broken | - | - | - | $424,991 | 725 | $10,572,742 | Jan 9 | Screen Gems | false |
| 17 | Twilight | - | - | - | $376,862 | 3,649 | $192,769,854 | Nov 21 | Summit Entertainment | false |
| 18 | Revolutionary Road | - | - | - | $375,886 | 1,077 | $22,911,480 | Dec 26 | Paramount Vantage | false |
| 19 | The Wrestler | - | - | - | $341,551 | 776 | $26,238,243 | Dec 17 | Fox Searchlight Pictures | false |
| 20 | The Tale of Despereaux | - | - | - | $313,200 | 3,107 | $50,877,145 | Dec 19 | Universal Pictures | false |
| 21 | Doubt | - | - | - | $243,423 | 1,287 | $33,446,470 | Dec 12 | Miramax | false |
| 22 | The Reader | - | - | - | $233,135 | 1,203 | $34,194,407 | Dec 10 | The Weinstein Company | false |
| 23 | Seven Pounds | - | - | - | $197,582 | 2,758 | $69,951,824 | Dec 19 | Sony Pictures Releasing | false |
| 24 | Milk | - | - | - | $163,409 | 882 | $31,841,299 | Nov 26 | Focus Features | false |
| 25 | Madagascar: Escape 2 Africa | - | - | - | $158,665 | 4,065 | $180,010,950 | Nov 7 | DreamWorks | false |
| 26 | Frost/Nixon | - | - | - | $149,190 | 1,105 | $18,622,031 | Dec 5 | Universal Pictures | false |
| 27 | Bolt | - | - | - | $141,509 | 3,654 | $114,053,579 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 28 | The Day the Earth Stood Still | - | - | - | $79,300 | 3,560 | $79,366,978 | Dec 12 | Twentieth Century Fox | false |
| 29 | Four Christmases | - | - | - | $62,438 | 3,540 | $120,146,040 | Nov 26 | Warner Bros. | false |
| 30 | Quantum of Solace | - | - | - | $60,854 | 3,501 | $168,368,427 | Nov 14 | Sony Pictures Releasing | false |
| 31 | CC2C | - | - | - | $55,877 | 130 | $921,738 | Jan 16 | Warner Bros. | false |
| 32 | Australia | - | - | - | $49,937 | 2,721 | $49,554,002 | Nov 26 | Twentieth Century Fox | false |
| 33 | Che: Part One/Che: Part Two | - | - | - | $45,335 | 39 | $1,497,109 | Dec 12 | IFC Films | false |
| 34 | Beverly Hills Chihuahua | - | - | - | $42,659 | 3,239 | $94,514,402 | Oct 3 | Walt Disney Studios Motion Pictures | false |
| 35 | Rachel Getting Married | - | - | - | $23,718 | 391 | $12,796,841 | Oct 3 | Sony Pictures Classics | false |
| 36 | High School Musical 3: Senior Year | - | - | - | $18,041 | 3,626 | $90,559,416 | Oct 24 | Walt Disney Studios Motion Pictures | false |
| 37 | Role Models | - | - | - | $17,775 | 2,798 | $67,294,270 | Nov 7 | Universal Pictures | false |
| 38 | Vicky Cristina Barcelona | - | - | - | $17,544 | 726 | $23,216,709 | Aug 15 | Metro-Goldwyn-Mayer (MGM) | false |
| 39 | The Spirit | - | - | - | $16,552 | 2,509 | $19,806,188 | Dec 25 | Lionsgate | false |
| 40 | Happy-Go-Lucky | - | - | - | $11,792 | 202 | $3,512,016 | Oct 10 | Miramax | false |
| 41 | The Secret Life of Bees | - | - | - | $8,109 | 1,630 | $37,770,162 | Oct 17 | Fox Searchlight Pictures | false |
| 42 | The Boy in the Striped Pajamas | - | - | - | $7,142 | 679 | $9,046,156 | Nov 7 | Miramax | false |
| 43 | Soul Men | - | - | - | $5,601 | 2,048 | $12,082,391 | Nov 7 | Metro-Goldwyn-Mayer (MGM) | false |
| 44 | Made in U.S.A | - | - | - | $4,866 | 2 | $95,209 | Jan 9 | Rialto Pictures | false |
| 45 | Silent Light | - | - | - | $3,988 | 1 | $60,200 | Jan 7 | Palisades Tartan | false |
| 46 | Zack and Miri Make a Porno | - | - | - | $3,827 | 2,735 | $31,457,946 | Oct 31 | The Weinstein Company | false |
| 47 | Deep Sea | - | - | - | $2,199 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 48 | Appaloosa | - | - | - | $2,183 | 1,290 | $20,211,394 | Sep 19 | Warner Bros. | false |
| 49 | The Haunting of Molly Hartley | - | - | - | $1,774 | 2,652 | $13,559,812 | Oct 31 | Freestyle Releasing | false |
| 50 | Nothing Like the Holidays | - | - | - | $1,398 | 1,671 | $7,503,736 | Dec 12 | Overture Films | false |
| 51 | Igor | - | - | - | $691 | 2,341 | $19,528,602 | Sep 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 52 | Lola Montès | - | - | - | $277 | 4 | $120,306 | Oct 10 | Rialto Pictures | false |
| 53 | The Dark Knight | - | - | - | $245 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 54 | Were the World Mine | - | - | - | $36 | 4 | $123,789 | Oct 31 | SPEAK Productions | false |
