| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Cloverfield | - | - | - | $6,088,317 | 3,411 | $80,048,433 | Jan 18 | Paramount Pictures | false |
| 2 | 27 Dresses | - | - | - | $4,434,315 | 3,074 | $76,808,654 | Jan 18 | Twentieth Century Fox | false |
| 3 | The Bucket List | - | - | - | $2,585,476 | 2,915 | $93,466,502 | Dec 25 | Warner Bros. | false |
| 4 | Alvin and the Chipmunks | - | - | - | $2,483,938 | 3,499 | $217,326,974 | Dec 14 | Twentieth Century Fox | false |
| 5 | National Treasure: Book of Secrets | - | - | - | $2,056,072 | 3,832 | $219,964,115 | Dec 21 | Walt Disney Studios Motion Pictures | false |
| 6 | Juno | - | - | - | $2,011,208 | 2,534 | $143,495,265 | Dec 5 | Fox Searchlight Pictures | false |
| 7 | First Sunday | - | - | - | $1,703,891 | 2,213 | $37,931,869 | Jan 11 | Screen Gems | false |
| 8 | Mad Money | - | - | - | $1,537,192 | 2,470 | $20,668,843 | Jan 18 | Overture Films | false |
| 9 | The Pirates Who Don't Do Anything: A VeggieTales Movie | - | - | - | $1,199,335 | 1,340 | $12,981,269 | Jan 11 | Universal Pictures | false |
| 10 | I Am Legend | - | - | - | $1,014,070 | 3,648 | $256,393,010 | Dec 14 | Warner Bros. | false |
| 11 | The Water Horse | - | - | - | $951,138 | 2,777 | $40,946,255 | Dec 25 | Revolution Studios | false |
| 12 | Atonement | - | - | - | $931,533 | 1,400 | $50,927,067 | Dec 7 | Focus Features | false |
| 13 | There Will Be Blood | - | - | - | $720,410 | 1,620 | $40,222,514 | Dec 26 | Paramount Vantage | false |
| 14 | Sweeney Todd: The Demon Barber of Fleet Street | - | - | - | $567,631 | 1,507 | $52,898,073 | Dec 21 | DreamWorks | false |
| 15 | Enchanted | - | - | - | $508,951 | 3,730 | $127,807,262 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 16 | One Missed Call | - | - | - | $483,216 | 2,240 | $26,890,041 | Jan 4 | Warner Bros. | false |
| 17 | The Great Debaters | - | - | - | $421,099 | 1,290 | $30,236,407 | Dec 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 18 | P.S. I Love You | - | - | - | $396,271 | 2,471 | $53,695,808 | Dec 21 | Warner Bros. | false |
| 19 | Charlie Wilson's War | - | - | - | $392,065 | 2,594 | $66,661,095 | Dec 21 | Universal Pictures | false |
| 20 | No Country for Old Men | - | - | - | $306,781 | 2,037 | $74,283,625 | Nov 9 | Miramax | false |
| 21 | In the Name of the King: A Dungeon Siege Tale | - | - | - | $265,473 | 1,632 | $4,775,656 | Jan 11 | Freestyle Releasing | false |
| 22 | The Orphanage | - | - | - | $239,614 | 707 | $7,161,284 | Dec 28 | Picturehouse | false |
| 23 | The Kite Runner | - | - | - | $230,852 | 715 | $15,800,078 | Dec 14 | Paramount Vantage | false |
| 24 | The Golden Compass | - | - | - | $127,661 | 3,528 | $70,107,728 | Dec 7 | New Line Cinema | false |
| 25 | The Savages | - | - | - | $94,550 | 201 | $6,623,082 | Nov 28 | Fox Searchlight Pictures | false |
| 26 | Bee Movie | - | - | - | $86,087 | 3,984 | $126,631,277 | Nov 2 | DreamWorks | false |
| 27 | The Diving Bell and the Butterfly | - | - | - | $83,919 | 213 | $6,003,227 | Nov 30 | Miramax | false |
| 28 | Cassandra's Dream | - | - | - | $75,742 | 107 | $973,018 | Jan 18 | The Weinstein Company | false |
| 29 | The Game Plan | - | - | - | $61,293 | 3,342 | $90,648,202 | Sep 28 | Walt Disney Studios Motion Pictures | false |
| 30 | Aliens vs. Predator: Requiem | - | - | - | $60,500 | 2,617 | $41,797,066 | Dec 25 | Twentieth Century Fox | false |
| 31 | August Rush | - | - | - | $53,143 | 2,310 | $31,664,162 | Nov 21 | Warner Bros. | false |
| 32 | Into the Wild | - | - | - | $42,161 | 660 | $18,354,356 | Sep 21 | Paramount Vantage | false |
| 33 | Persepolis | - | - | - | $41,929 | 536 | $4,445,756 | Dec 25 | Sony Pictures Classics | false |
| 34 | Mr. Magorium's Wonder Emporium | - | - | - | $40,005 | 3,168 | $32,061,555 | Nov 16 | Twentieth Century Fox | false |
| 35 | Beowulf | - | - | - | $35,877 | 3,249 | $82,280,579 | Nov 16 | Paramount Pictures | false |
| 36 | American Gangster | - | - | - | $22,365 | 3,110 | $130,164,645 | Nov 2 | Universal Pictures | false |
| 37 | Deep Sea | - | - | - | $12,941 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 38 | Fred Claus | - | - | - | $12,637 | 3,603 | $72,006,777 | Nov 9 | Warner Bros. | false |
| 39 | Michael Clayton | - | - | - | $11,132 | 2,585 | $49,033,882 | Oct 5 | Warner Bros. | false |
| 40 | I'm Not There | - | - | - | $9,969 | 149 | $4,017,609 | Nov 21 | The Weinstein Company | false |
| 41 | Hitman | - | - | - | $8,243 | 2,468 | $39,687,694 | Nov 21 | Twentieth Century Fox | false |
| 42 | Teeth | - | - | - | $7,009 | 16 | $347,578 | Jan 18 | Roadside Attractions | false |
| 43 | Lions for Lambs | - | - | - | $4,680 | 2,216 | $15,002,854 | Nov 9 | United Artists | false |
| 44 | Lars and the Real Girl | - | - | - | $3,843 | 321 | $5,972,884 | Oct 12 | Metro-Goldwyn-Mayer (MGM) | false |
| 45 | Last Year at Marienbad | - | - | - | $3,616 | 2 | $144,492 | Jan 18 | Rialto Pictures | false |
| 46 | The Mist | - | - | - | $3,003 | 2,423 | $25,594,957 | Nov 21 | Metro-Goldwyn-Mayer (MGM) | false |
| 47 | The Perfect Holiday | - | - | - | $2,927 | 1,307 | $5,812,781 | Dec 12 | Yari Film Group Releasing | false |
| 48 | The Darjeeling Limited | - | - | - | $2,530 | 698 | $11,902,715 | Sep 29 | Fox Searchlight Pictures | false |
| 49 | Blade Runner The Final Cut (2007 re-release) | - | - | - | $1,958 | 20 | $1,548,502 | Oct 5 | Warner Bros. | false |
| 50 | Lust, Caution | - | - | - | $1,933 | 143 | $4,604,982 | Sep 28 | Focus Features | false |
| 51 | Awake | - | - | - | $1,815 | 2,023 | $14,377,198 | Nov 30 | Metro-Goldwyn-Mayer (MGM) | false |
| 52 | Bella | - | - | - | $1,123 | 457 | $8,070,537 | Oct 26 | Roadside Attractions | false |
| 53 | Margot at the Wedding | - | - | - | $1,076 | 121 | $1,959,420 | Nov 16 | Paramount Vantage | false |
| 54 | Control | - | - | - | $957 | 29 | $872,252 | Oct 10 | The Weinstein Company | false |
| 55 | The Assassination of Jesse James by the Coward Robert Ford | - | - | - | $353 | 301 | $3,909,149 | Sep 21 | Warner Bros. | false |
