| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $4,685,510 | 3,768 | $250,863,268 | Dec 22 | Twentieth Century Fox | false |
| 2 | Stomp the Yard | - | - | - | $4,043,006 | 2,169 | $61,356,221 | Jan 12 | Screen Gems | false |
| 3 | Dreamgirls | - | - | - | $1,897,460 | 2,797 | $103,365,956 | Dec 15 | DreamWorks | false |
| 4 | The Pursuit of Happyness | - | - | - | $1,802,146 | 3,169 | $163,566,459 | Dec 15 | Sony Pictures Releasing | false |
| 5 | Charlotte's Web | - | - | - | $1,562,379 | 3,745 | $82,985,708 | Dec 15 | Paramount Pictures | false |
| 6 | Freedom Writers | - | - | - | $1,524,152 | 2,286 | $36,605,602 | Jan 5 | Paramount Pictures | false |
| 7 | Arthur and the Invisibles | - | - | - | $1,407,853 | 2,248 | $15,132,763 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 8 | Happily N'Ever After | - | - | - | $1,148,896 | 2,381 | $15,589,393 | Jan 5 | Lionsgate | false |
| 9 | Children of Men | - | - | - | $1,078,220 | 1,524 | $35,552,383 | Dec 25 | Universal Pictures | false |
| 10 | Alpha Dog | - | - | - | $998,975 | 1,292 | $15,309,602 | Jan 12 | Universal Pictures | false |
| 11 | Happy Feet | - | - | - | $843,014 | 3,804 | $198,000,317 | Nov 17 | Warner Bros. | false |
| 12 | Primeval | - | - | - | $744,003 | 2,444 | $10,597,734 | Jan 12 | Walt Disney Studios Motion Pictures | false |
| 13 | The Good Shepherd | - | - | - | $638,080 | 2,250 | $59,952,835 | Dec 22 | Universal Pictures | false |
| 14 | Eragon | - | - | - | $570,277 | 3,030 | $75,030,163 | Dec 15 | Twentieth Century Fox | false |
| 15 | Rocky Balboa | - | - | - | $556,845 | 3,019 | $70,270,943 | Dec 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 16 | We Are Marshall | - | - | - | $458,846 | 2,606 | $43,545,364 | Dec 22 | Warner Bros. | false |
| 17 | Pan's Labyrinth | - | - | - | $442,966 | 1,143 | $37,634,615 | Dec 29 | Picturehouse | false |
| 18 | Blood Diamond | - | - | - | $412,816 | 1,920 | $57,377,916 | Dec 8 | Warner Bros. | false |
| 19 | Code Name: The Cleaner | - | - | - | $346,038 | 1,736 | $8,135,024 | Jan 5 | New Line Cinema | false |
| 20 | Curse of the Golden Flower | - | - | - | $317,213 | 1,234 | $6,566,773 | Dec 21 | Sony Pictures Classics | false |
| 21 | Notes on a Scandal | - | - | - | $315,171 | 682 | $17,510,118 | Dec 25 | Fox Searchlight Pictures | false |
| 22 | Casino Royale | - | - | - | $273,789 | 3,443 | $167,445,960 | Nov 17 | Sony Pictures Releasing | false |
| 23 | The Holiday | - | - | - | $246,774 | 2,698 | $63,224,849 | Dec 8 | Sony Pictures Releasing | false |
| 24 | The Queen | - | - | - | $243,716 | 1,850 | $56,441,711 | Sep 30 | Miramax | false |
| 25 | The Painted Veil | - | - | - | $194,910 | 287 | $8,060,487 | Dec 20 | Warner Independent Pictures (WIP) | false |
| 26 | Apocalypto | - | - | - | $166,265 | 2,465 | $50,866,635 | Dec 8 | Walt Disney Studios Motion Pictures | false |
| 27 | Flushed Away | - | - | - | $103,387 | 3,707 | $64,665,672 | Nov 3 | DreamWorks | false |
| 28 | Letters from Iwo Jima | - | - | - | $83,720 | 781 | $13,756,082 | Dec 20 | Warner Bros. | false |
| 29 | Volver | - | - | - | $80,381 | 689 | $12,899,867 | Nov 3 | Sony Pictures Classics | false |
| 30 | Babel | - | - | - | $77,992 | 1,251 | $34,302,837 | Oct 27 | Paramount Vantage | false |
| 31 | Perfume: The Story of a Murderer | - | - | - | $55,973 | 280 | $2,223,293 | Dec 27 | DreamWorks | false |
| 32 | The Departed | - | - | - | $55,257 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 33 | Borat | - | - | - | $45,849 | 2,611 | $128,505,958 | Nov 3 | Twentieth Century Fox | false |
| 34 | Black Christmas | - | - | - | $36,465 | 1,544 | $16,273,581 | Dec 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 35 | Miss Potter | - | - | - | $31,751 | 102 | $3,005,605 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 36 | Deep Sea | - | - | - | $28,668 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 37 | The History Boys | - | - | - | $16,283 | 165 | $2,706,659 | Nov 21 | Fox Searchlight Pictures | false |
| 38 | The Good German | - | - | - | $13,610 | 66 | $1,308,696 | Dec 15 | Warner Bros. | false |
| 39 | Unaccompanied Minors | - | - | - | $13,370 | 2,775 | $16,655,224 | Dec 8 | Warner Bros. | false |
| 40 | Deck the Halls | - | - | - | $10,017 | 3,205 | $35,093,569 | Nov 22 | Twentieth Century Fox | false |
| 41 | The Polar Express 2006 IMAX Release | - | - | - | $6,041 | 37 | $2,940,722 | Nov 17 | Warner Bros. | false |
| 42 | The Last King of Scotland | - | - | - | $4,352 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 43 | Bobby | - | - | - | $4,289 | 1,670 | $11,242,801 | Nov 17 | Metro-Goldwyn-Mayer (MGM) | false |
| 44 | For Your Consideration | - | - | - | $3,565 | 625 | $5,549,923 | Nov 17 | Warner Independent Pictures (WIP) | false |
| 45 | The Wedding Weekend | - | - | - | $3,192 | 84 | $1,232,961 | Oct 27 | The Weinstein Company | false |
| 46 | The Illusionist | - | - | - | $2,584 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 47 | The Fountain | - | - | - | $2,004 | 1,472 | $10,144,010 | Nov 22 | Warner Bros. | false |
| 48 | Little Miss Sunshine | - | - | - | $1,903 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
