| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | A Quiet Place Part II | - | - | - | $57,088,948 | 3,744 | $160,072,261 | May 28 | Paramount Pictures | false |
| 2 | Cruella | - | - | - | $26,532,683 | 3,922 | $86,103,234 | May 28 | Walt Disney Studios Motion Pictures | false |
| 3 | Raya and the Last Dragon | - | - | - | $2,841,858 | 2,375 | $54,723,032 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 4 | Wrath of Man | - | - | - | $2,729,783 | 3,007 | $27,466,489 | May 7 | United Artists Releasing | false |
| 5 | Spiral | - | - | - | $2,697,963 | 2,991 | $23,216,862 | May 14 | Lionsgate Films | false |
| 6 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | - | - | - | $1,128,513 | 2,087 | $49,505,008 | Apr 23 | FUNimation Entertainment | false |
| 7 | Godzilla vs. Kong | - | - | - | $1,105,801 | 3,084 | $100,916,094 | Mar 31 | Warner Bros. | false |
| 8 | Dream Horse | - | - | - | $831,033 | 1,284 | $2,913,328 | May 21 | Bleecker Street Media | false |
| 9 | Those Who Wish Me Dead | - | - | - | $739,767 | 3,379 | $7,407,200 | May 14 | Warner Bros. | false |
| 10 | World War Z 2021 Re-release | - | - | - | $448,000 | 80 | $448,000 | May 28 | Paramount Pictures | true |
| 11 | Finding You | - | - | - | $339,594 | 1,447 | $2,753,985 | May 14 | Roadside Attractions | false |
| 12 | Mortal Kombat | - | - | - | $330,772 | 3,114 | $42,326,031 | Apr 23 | Warner Bros. | false |
| 13 | Tom & Jerry | - | - | - | $159,246 | 2,563 | $46,536,687 | Feb 26 | Warner Bros. | false |
| 14 | Nobody | - | - | - | $139,250 | 2,567 | $27,568,035 | Mar 26 | Universal Pictures | false |
| 15 | The Unholy | - | - | - | $113,927 | 2,057 | $15,532,137 | Apr 2 | Screen Gems | false |
| 16 | Here Today | - | - | - | $95,306 | 1,230 | $2,807,494 | May 7 | Stage 6 Films | false |
| 17 | Final Account | - | - | - | $88,065 | 308 | $308,976 | May 21 | Focus Features | false |
| 18 | The Dry | - | - | - | $78,651 | 186 | $364,237 | May 21 | IFC Films | false |
| 19 | The Croods: A New Age | - | - | - | $72,945 | 2,211 | $58,568,815 | Nov 25 | Universal Pictures | false |
| 20 | New Order | - | - | - | $64,590 | 236 | $303,556 | May 21 | Neon | false |
| 21 | Profile | - | - | - | $39,505 | 2,104 | $1,744,740 | May 14 | Focus Features | false |
| 22 | Separation | - | - | - | $33,721 | 1,911 | $4,509,143 | Apr 30 | Open Road Films (II) | false |
| 23 | The Truffle Hunters | - | - | - | $29,047 | 105 | $521,202 | Mar 5 | Sony Pictures Classics | false |
| 24 | The Courier | - | - | - | $23,931 | 1,641 | $6,613,432 | Mar 19 | Roadside Attractions | false |
| 25 | Riders of Justice | - | - | - | $15,960 | 18 | $77,115 | May 14 | Magnolia Pictures | false |
| 26 | The Girl Who Believes in Miracles | - | - | - | $12,250 | 1,012 | $3,163,362 | Apr 2 | Atlas Distribution Company | false |
| 27 | French Exit | - | - | - | $12,235 | 493 | $741,895 | Feb 12 | Sony Pictures Classics | false |
| 28 | The Djinn | - | - | - | $11,144 | 44 | $124,772 | May 14 | IFC Films | false |
| 29 | The Swimming Pool 2021 Re-release | - | - | - | $10,447 | 10 | $211,467 | May 14 | Rialto Distribution | false |
| 30 | Together Together | - | - | - | $9,594 | 665 | $1,437,938 | Apr 23 | Bleecker Street Media | false |
| 31 | The Father | - | - | - | $9,370 | 933 | $2,122,771 | Feb 26 | Sony Pictures Classics | false |
| 32 | The Killing of Two Lovers | - | - | - | $8,594 | 36 | $71,162 | May 14 | Neon | false |
| 33 | The Paper Tigers | - | - | - | $5,515 | 65 | $112,691 | May 7 | Well Go USA Entertainment | false |
| 34 | The Perfect Candidate | - | - | - | $5,062 | 17 | $30,134 | May 14 | Music Box Films | false |
| 35 | Shiva Baby | - | - | - | $4,752 | 27 | $159,294 | Apr 2 | Utopia | false |
| 36 | Cliff Walkers | - | - | - | $3,502 | 65 | $152,972 | Apr 30 | CMC Pictures | false |
| 37 | The War with Grandpa | - | - | - | $3,266 | 2,365 | $21,277,892 | Oct 9 | 101 Studios | false |
| 38 | About Endlessness | - | - | - | $3,150 | 17 | $51,386 | Apr 30 | Magnolia Pictures | false |
| 39 | My Love | - | - | - | $2,411 | 25 | $86,252 | May 7 | CMC Pictures | false |
| 40 | Mission Stories | - | - | - | $1,980 | 44 | $87,059 | May 7 | Excel Entertainment | false |
| 41 | Mainstream | - | - | - | $853 | 76 | $35,696 | May 7 | IFC Films | false |
| 42 | The Incredible 25th Year of Mitzi Bearclaw | - | - | - | $510 | 2 | $10,368 | Feb 12 | Indican Pictures | false |
| 43 | Ghost Master | - | - | - | $344 | 2 | $6,136 | May 14 | Indican Pictures | false |
| 44 | Funhouse | - | - | - | $320 | 3 | $507 | May 28 | Magnet Releasing | false |
| 45 | Lamb of God: The Concert Film | - | - | - | $70 | 138 | $744,813 | Mar 12 | Excel Entertainment | false |
