| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Shrek Forever After | - | - | - | $57,060,434 | 4,386 | $238,736,787 | May 21 | DreamWorks | false |
| 2 | Prince of Persia: The Sands of Time | - | - | - | $37,813,075 | 3,646 | $90,759,676 | May 28 | Walt Disney Studios Motion Pictures | false |
| 3 | Sex and the City 2 | - | - | - | $36,835,353 | 3,445 | $95,347,692 | May 27 | Warner Bros. | false |
| 4 | Iron Man 2 | - | - | - | $21,076,239 | 4,390 | $312,433,331 | May 7 | Paramount Pictures | false |
| 5 | Robin Hood | - | - | - | $13,424,540 | 3,505 | $105,269,730 | May 14 | Universal Pictures | false |
| 6 | Letters to Juliet | - | - | - | $7,492,524 | 2,975 | $53,032,453 | May 14 | Summit Entertainment | false |
| 7 | Just Wright | - | - | - | $2,835,702 | 1,831 | $21,540,363 | May 14 | Fox Searchlight Pictures | false |
| 8 | Date Night | - | - | - | $2,307,657 | 3,380 | $98,711,404 | Apr 9 | Twentieth Century Fox | false |
| 9 | MacGruber | - | - | - | $2,024,110 | 2,551 | $8,525,600 | May 21 | Universal Pictures | false |
| 10 | How to Train Your Dragon | - | - | - | $1,513,677 | 4,060 | $217,581,231 | Mar 26 | DreamWorks | false |
| 11 | A Nightmare on Elm Street | - | - | - | $1,127,395 | 3,332 | $63,075,011 | Apr 30 | Warner Bros. | false |
| 12 | Alice in Wonderland | - | - | - | $730,145 | 3,739 | $334,191,110 | Mar 5 | Walt Disney Studios Motion Pictures | false |
| 13 | Babies | - | - | - | $642,273 | 543 | $7,320,323 | May 7 | Focus Features | false |
| 14 | The Secret in Their Eyes | - | - | - | $577,670 | 166 | $6,391,436 | Apr 16 | Sony Pictures Classics | false |
| 15 | City Island | - | - | - | $532,862 | 269 | $6,671,036 | Mar 19 | Anchor Bay Films | false |
| 16 | The Girl with the Dragon Tattoo | - | - | - | $502,055 | 202 | $10,095,170 | Mar 19 | Music Box Films | false |
| 17 | Hubble | - | - | - | $423,169 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 18 | The Back-up Plan | - | - | - | $359,677 | 3,280 | $37,490,007 | Apr 23 | CBS Films | false |
| 19 | The Bounty Hunter | - | - | - | $354,260 | 3,118 | $67,061,228 | Mar 19 | Sony Pictures Releasing | false |
| 20 | Diary of a Wimpy Kid | - | - | - | $335,000 | 3,083 | $64,003,625 | Mar 19 | Twentieth Century Fox | false |
| 21 | Kites | - | - | - | $315,016 | 207 | $1,643,486 | May 21 | Reliance Big Pictures | false |
| 22 | Death at a Funeral | - | - | - | $290,528 | 2,459 | $42,739,347 | Apr 16 | Screen Gems | false |
| 23 | Hot Tub Time Machine | - | - | - | $285,782 | 2,771 | $50,287,556 | Mar 26 | Metro-Goldwyn-Mayer (MGM) | false |
| 24 | Clash of the Titans | - | - | - | $278,708 | 3,802 | $163,214,888 | Apr 2 | Warner Bros. | false |
| 25 | Please Give | - | - | - | $255,836 | 272 | $4,033,574 | Apr 30 | Sony Pictures Classics | false |
| 26 | The Last Song | - | - | - | $247,405 | 2,794 | $62,950,384 | Mar 31 | Walt Disney Studios Motion Pictures | false |
| 27 | Exit Through the Gift Shop | - | - | - | $241,171 | 46 | $3,291,250 | Apr 16 | Producers Distribution Agency (PDA) | false |
| 28 | Furry Vengeance | - | - | - | $217,303 | 3,002 | $17,630,465 | Apr 30 | Summit Entertainment | false |
| 29 | Shutter Island | - | - | - | $202,436 | 3,356 | $128,012,934 | Feb 19 | Paramount Pictures | false |
| 30 | Kick-Ass | - | - | - | $198,960 | 3,065 | $48,071,303 | Apr 16 | Lionsgate | false |
| 31 | Oceans | - | - | - | $174,685 | 1,232 | $19,422,319 | Apr 22 | Walt Disney Studios Motion Pictures | false |
| 32 | Harry Brown | - | - | - | $168,860 | 67 | $1,818,681 | Apr 30 | The Samuel Goldwyn Company | false |
| 33 | Why Did I Get Married Too? | - | - | - | $150,708 | 2,155 | $60,095,852 | Apr 2 | Lionsgate | false |
| 34 | Avatar | - | - | - | $144,241 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 35 | Princess Kaiulani | - | - | - | $122,396 | 47 | $883,887 | May 14 | Roadside Attractions | false |
| 36 | The Losers | - | - | - | $119,149 | 2,936 | $23,591,432 | Apr 23 | Warner Bros. | false |
| 37 | Solitary Man | - | - | - | $110,531 | 177 | $4,360,548 | May 21 | Anchor Bay Films | false |
| 38 | The Ghost Writer | - | - | - | $92,981 | 819 | $15,541,549 | Feb 19 | Summit Entertainment | false |
| 39 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $82,957 | 3,396 | $88,768,303 | Feb 12 | Twentieth Century Fox | false |
| 40 | Mother and Child | - | - | - | $72,226 | 119 | $1,110,509 | May 7 | Sony Pictures Classics | false |
| 41 | Holy Rollers | - | - | - | $71,955 | 20 | $303,064 | May 21 | First Independent Pictures | false |
| 42 | Under the Sea 3D | - | - | - | $64,014 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 43 | Survival of the Dead | - | - | - | $54,605 | 20 | $101,740 | May 28 | Magnolia Pictures | false |
| 44 | Micmacs | - | - | - | $51,914 | 52 | $1,262,079 | May 28 | Sony Pictures Classics | false |
| 45 | La Mission | - | - | - | $44,446 | 47 | $1,062,941 | Apr 9 | Screen Media Films | false |
| 46 | Agora | - | - | - | $44,313 | 17 | $619,423 | May 28 | Newmarket Films | false |
| 47 | Father of My Children | - | - | - | $42,538 | 7 | $144,022 | May 21 | IFC Films | false |
| 48 | Breathless 2010 Re-release | - | - | - | $41,449 | 12 | $363,031 | May 28 | Rialto Pictures | false |
| 49 | Tooth Fairy | - | - | - | $41,162 | 3,345 | $60,022,256 | Jan 22 | Twentieth Century Fox | false |
| 50 | The Secret of Kells | - | - | - | $34,503 | 37 | $676,775 | Mar 5 | GKIDS | false |
| 51 | Our Family Wedding | - | - | - | $32,047 | 1,609 | $20,255,281 | Mar 12 | Fox Searchlight Pictures | false |
| 52 | Magnificent Desolation: Walking on the Moon | - | - | - | $31,231 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 53 | Kites The Remix | - | - | - | $31,191 | 40 | $41,783 | May 28 | Reliance Big Pictures | false |
| 54 | The City of Your Final Destination | - | - | - | $28,954 | 26 | $493,296 | Apr 16 | Screen Media Films | false |
| 55 | Casino Jack and the United States of Money | - | - | - | $27,977 | 21 | $176,865 | May 7 | Magnolia Pictures | false |
| 56 | Mid-August Lunch | - | - | - | $27,659 | 23 | $675,299 | Mar 17 | Zeitgeist Films | false |
| 57 | Mademoiselle Chambon | - | - | - | $25,595 | 16 | $531,685 | May 28 | Lorber Films | false |
| 58 | Only the Brave | - | - | - | $22,135 | 5 | $150,000 | May 28 | Indican Pictures | false |
| 59 | Deep Sea | - | - | - | $21,674 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 60 | The Square 2010 Re-release | - | - | - | $21,307 | 24 | $406,116 | Apr 9 | Apparition | false |
| 61 | The Cremaster Cycle 2010 Re-release | - | - | - | $15,547 | 2 | $151,239 | Apr 9 | International Film Circuit | false |
| 62 | The Human Centipede (First Sequence) | - | - | - | $14,216 | 19 | $181,467 | Apr 30 | IFC Films | false |
| 63 | Mother | - | - | - | $12,263 | 38 | $551,509 | Mar 12 | Magnolia Pictures | false |
| 64 | The Good the Bad the Weird | - | - | - | $11,522 | 15 | $128,486 | Apr 23 | IFC Films | false |
| 65 | Metropolis 2010 Re-release | - | - | - | $11,327 | 9 | $529,603 | May 7 | Kino International | false |
| 66 | A Prophet | - | - | - | $10,296 | 83 | $2,087,720 | Feb 26 | Sony Pictures Classics | false |
| 67 | Chloe | - | - | - | $9,945 | 350 | $3,075,255 | Mar 26 | Sony Pictures Classics | false |
| 68 | Vincere | - | - | - | $9,810 | 36 | $619,162 | Mar 19 | IFC Films | false |
| 69 | Looking for Eric | - | - | - | $9,244 | 11 | $55,804 | May 14 | IFC Films | false |
| 70 | Sea Monsters: A Prehistoric Adventure | - | - | - | $8,755 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 71 | Two in the Wave | - | - | - | $7,332 | 1 | $28,808 | May 19 | Lorber Films | false |
| 72 | 180° South | - | - | - | $6,645 | 4 | $31,745 | May 21 | Magnolia Pictures | false |
| 73 | Racing Dreams | - | - | - | $6,133 | 33 | $65,082 | May 21 | Hannover House | false |
| 74 | Best Worst Movie | - | - | - | $5,852 | 2 | $109,895 | Apr 23 | Abramorama | false |
| 75 | Letters to God | - | - | - | $5,229 | 897 | $2,848,578 | Apr 9 | Vivendi Entertainment | false |
| 76 | John Rabe | - | - | - | $5,199 | 6 | $67,519 | May 21 | Strand Releasing | false |
| 77 | The Eclipse | - | - | - | $5,115 | 12 | $133,411 | Mar 26 | Magnolia Pictures | false |
| 78 | OSS 117: Lost in Rio | - | - | - | $5,105 | 7 | $89,375 | May 7 | Music Box Films | false |
| 79 | The Runaways | - | - | - | $4,278 | 244 | $3,573,673 | Mar 19 | Apparition | false |
| 80 | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | - | - | - | $4,276 | 12 | $453,993 | Jan 29 | First Run | false |
| 81 | The Joneses | - | - | - | $3,807 | 217 | $1,475,746 | Apr 16 | Roadside Attractions | false |
| 82 | No One Knows About Persian Cats | - | - | - | $3,681 | 12 | $81,768 | Apr 16 | IFC Films | false |
| 83 | Touching Home | - | - | - | $3,630 | 7 | $116,353 | Apr 30 | CFI Releasing | false |
| 84 | Crazy Heart | - | - | - | $3,563 | 1,361 | $39,464,306 | Dec 16 | Fox Searchlight Pictures | false |
| 85 | Sweetgrass | - | - | - | $3,517 | 9 | $207,473 | Jan 6 | The Cinema Guild | false |
| 86 | Daddy Longlegs | - | - | - | $2,517 | 2 | $21,766 | May 14 | IFC Films | false |
| 87 | Beetle Queen Conquers Tokyo | - | - | - | $2,387 | 3 | $32,308 | May 12 | Argot Pictures | false |
| 88 | Prodigal Sons | - | - | - | $2,220 | 11 | $73,544 | Feb 26 | First Run | false |
| 89 | Ajami | - | - | - | $2,111 | 23 | $622,403 | Feb 3 | Kino International | false |
| 90 | After the Cup: Sons of Sakhnin United | - | - | - | $1,840 | 3 | $11,538 | May 21 | Variance Films | false |
| 91 | House | - | - | - | $1,624 | 7 | $209,765 | Jan 15 | Janus Films | false |
| 92 | Valley of the Heart's Delight | - | - | - | $1,237 | 8 | $119,290 | Apr 9 | Indican Pictures | false |
| 93 | Dancing Across Borders | - | - | - | $1,022 | 5 | $66,166 | Mar 26 | First Run | false |
| 94 | Behind the Burly Q | - | - | - | $900 | 2 | $23,889 | Apr 23 | First Run | false |
| 95 | Space Station 3D | - | - | - | $849 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 96 | U2 3D | - | - | - | $592 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 97 | Here and There | - | - | - | $568 | 5 | $27,156 | May 14 | Cinema Purgatorio | false |
| 98 | October Country | - | - | - | $541 | 4 | $26,185 | Feb 12 | International Film Circuit | false |
| 99 | The Last Station | - | - | - | $534 | 354 | $6,617,867 | Jan 15 | Sony Pictures Classics | false |
| 100 | The Girl on the Train | - | - | - | $457 | 10 | $208,023 | Jan 22 | Strand Releasing | false |
| 101 | Small Change | - | - | - | $448 | 2 | $38,296 | Nov 24 | The Film Desk | false |
| 102 | The White Ribbon | - | - | - | $245 | 106 | $2,222,862 | Dec 30 | Sony Pictures Classics | false |
| 103 | Promised Lands | - | - | - | $52 | 1 | $4,546 | Feb 5 | The Film Desk | false |
