| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Pirates of the Caribbean: At World's End | - | - | - | $139,802,190 | 4,362 | $309,420,425 | May 25 | Walt Disney Studios Motion Pictures | false |
| 2 | Shrek the Third | - | - | - | $67,010,012 | 4,172 | $322,719,944 | May 18 | DreamWorks | false |
| 3 | Spider-Man 3 | - | - | - | $18,112,261 | 4,324 | $336,530,303 | May 4 | Sony Pictures Releasing | false |
| 4 | Bug | - | - | - | $4,015,846 | 1,661 | $7,025,810 | May 25 | Lionsgate | false |
| 5 | Waitress | - | - | - | $4,005,008 | 707 | $19,074,800 | May 2 | Fox Searchlight Pictures | false |
| 6 | 28 Weeks Later | - | - | - | $3,280,306 | 2,305 | $28,638,916 | May 11 | Fox Atomic | false |
| 7 | Disturbia | - | - | - | $2,433,028 | 3,132 | $80,209,692 | Apr 13 | DreamWorks | false |
| 8 | Georgia Rule | - | - | - | $2,407,910 | 2,531 | $19,103,072 | May 11 | Universal Pictures | false |
| 9 | Fracture | - | - | - | $1,646,761 | 2,443 | $39,015,018 | Apr 20 | New Line Cinema | false |
| 10 | Wild Hogs | - | - | - | $1,586,929 | 3,401 | $168,273,550 | Mar 2 | Walt Disney Studios Motion Pictures | false |
| 11 | The Invisible | - | - | - | $1,102,840 | 2,019 | $20,578,909 | Apr 27 | Walt Disney Studios Motion Pictures | false |
| 12 | Away from Her | - | - | - | $947,459 | 275 | $4,571,521 | May 4 | Lionsgate | false |
| 13 | Delta Farce | - | - | - | $649,713 | 1,931 | $8,130,530 | May 11 | Lionsgate | false |
| 14 | Blades of Glory | - | - | - | $643,146 | 3,467 | $118,594,548 | Mar 30 | DreamWorks | false |
| 15 | Hot Fuzz | - | - | - | $636,457 | 1,272 | $23,637,265 | Apr 20 | Rogue Pictures | false |
| 16 | Paris, Je T'aime | - | - | - | $550,796 | 200 | $4,899,278 | May 4 | First Look International | false |
| 17 | Once | - | - | - | $435,958 | 150 | $9,439,923 | May 16 | Fox Searchlight Pictures | false |
| 18 | 300 | - | - | - | $435,414 | 3,280 | $210,614,939 | Mar 9 | Warner Bros. | false |
| 19 | Next | - | - | - | $414,505 | 2,733 | $18,211,013 | Apr 27 | Paramount Pictures | false |
| 20 | Black Book | - | - | - | $411,891 | 193 | $4,398,532 | Apr 4 | Sony Pictures Classics | false |
| 21 | Are We Done Yet? | - | - | - | $382,613 | 2,944 | $49,662,533 | Apr 4 | Revolution Studios | false |
| 22 | Cheeni Kum | - | - | - | $346,245 | 51 | $697,369 | May 25 | Eros Worldwide | false |
| 23 | The Namesake | - | - | - | $293,600 | 335 | $13,569,248 | Mar 9 | Fox Searchlight Pictures | false |
| 24 | Meet the Robinsons | - | - | - | $287,045 | 3,435 | $97,822,171 | Mar 30 | Walt Disney Studios Motion Pictures | false |
| 25 | The Valet | - | - | - | $252,905 | 92 | $1,926,800 | Apr 20 | Sony Pictures Classics | false |
| 26 | Provoked | - | - | - | $246,230 | 62 | $761,740 | May 11 | Eros Worldwide | false |
| 27 | Vacancy | - | - | - | $225,524 | 2,551 | $19,363,565 | Apr 20 | Screen Gems | false |
| 28 | Grindhouse | - | - | - | $221,214 | 2,629 | $25,037,897 | Apr 6 | Dimension Films | false |
| 29 | The Lives of Others | - | - | - | $192,608 | 259 | $11,286,112 | Feb 9 | Sony Pictures Classics | false |
| 30 | Bridge to Terabithia | - | - | - | $188,798 | 3,210 | $82,272,442 | Feb 16 | Walt Disney Studios Motion Pictures | false |
| 31 | Deep Sea | - | - | - | $161,645 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 32 | Shootout at Lokhandwala | - | - | - | $158,227 | 34 | $289,232 | May 25 | Rainbow Releasing | false |
| 33 | Shooter | - | - | - | $149,056 | 2,806 | $47,003,582 | Mar 23 | Paramount Pictures | false |
| 34 | The Last Mimzy | - | - | - | $147,300 | 3,017 | $21,471,047 | Mar 23 | New Line Cinema | false |
| 35 | TMNT | - | - | - | $130,089 | 3,120 | $54,149,098 | Mar 23 | Warner Bros. | false |
| 36 | After the Wedding | - | - | - | $102,194 | 55 | $1,534,584 | Mar 30 | IFC Films | false |
| 37 | Orchestra Seats | - | - | - | $82,275 | 52 | $2,044,858 | Feb 16 | THINKFilm | false |
| 38 | The Ex | - | - | - | $74,791 | 1,009 | $3,093,394 | May 11 | Metro-Goldwyn-Mayer (MGM) | false |
| 39 | Year of the Dog | - | - | - | $73,147 | 152 | $1,540,141 | Apr 13 | Paramount Vantage | false |
| 40 | Firehouse Dog | - | - | - | $67,111 | 2,881 | $13,932,383 | Apr 4 | Twentieth Century Fox | false |
| 41 | Magnificent Desolation: Walking on the Moon | - | - | - | $65,854 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 42 | The Wind that Shakes the Barley | - | - | - | $62,637 | 50 | $1,836,089 | Mar 16 | IFC Films | false |
| 43 | Wild Safari - A South African Adventure | - | - | - | $59,332 | 21 | $16,621,530 | Apr 8 | nWave Pictures | false |
| 44 | The Reaping | - | - | - | $59,252 | 2,603 | $25,126,214 | Apr 5 | Warner Bros. | false |
| 45 | Roving Mars | - | - | - | $56,783 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 46 | Jindabyne | - | - | - | $54,298 | 25 | $400,438 | Apr 27 | Sony Pictures Classics | false |
| 47 | Brooklyn Rules | - | - | - | $52,492 | 25 | $458,232 | May 11 | City Lights Pictures | false |
| 48 | Night at the Museum | - | - | - | $48,206 | 3,768 | $250,863,268 | Dec 22 | Twentieth Century Fox | false |
| 49 | Paprika | - | - | - | $45,429 | 37 | $882,267 | May 25 | Sony Pictures Classics | false |
| 50 | Amazing Grace | - | - | - | $41,377 | 1,162 | $21,250,683 | Feb 23 | IDP Distribution | false |
| 51 | Angel-A | - | - | - | $39,234 | 18 | $202,647 | May 25 | Sony Pictures Classics | false |
| 52 | Golden Door | - | - | - | $37,947 | 33 | $1,070,769 | May 25 | Miramax | false |
| 53 | The Hoax | - | - | - | $37,558 | 1,069 | $7,164,995 | Apr 6 | Miramax | false |
| 54 | Lucky You | - | - | - | $35,424 | 2,525 | $5,758,950 | May 4 | Warner Bros. | false |
| 55 | In the Land of Women | - | - | - | $35,191 | 2,155 | $11,052,958 | Apr 20 | Warner Bros. | false |
| 56 | The Wendell Baker Story 2007 Re-release | - | - | - | $34,073 | 17 | $127,414 | May 18 | THINKFilm | false |
| 57 | Chalk | - | - | - | $32,455 | 7 | $302,845 | May 11 | Hart Sharp Entertainment | false |
| 58 | Miss Potter | - | - | - | $31,413 | 102 | $3,005,605 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 59 | Space Station 3D | - | - | - | $28,094 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 60 | Into Great Silence | - | - | - | $27,778 | 19 | $790,452 | Feb 28 | Zeitgeist Films | false |
| 61 | Fay Grim | - | - | - | $26,393 | 28 | $126,714 | May 18 | Magnolia Pictures | false |
| 62 | Ta Ra Rum Pum | - | - | - | $21,935 | 85 | $872,643 | Apr 27 | Yash Raj Films | false |
| 63 | Hollywood Dreams | - | - | - | $20,818 | 6 | $171,255 | May 18 | Rainbow Releasing | false |
| 64 | The Hills Have Eyes 2 | - | - | - | $18,052 | 2,465 | $20,804,166 | Mar 23 | Fox Atomic | false |
| 65 | Pathfinder | - | - | - | $15,865 | 1,756 | $10,232,081 | Apr 13 | Twentieth Century Fox | false |
| 66 | Pan's Labyrinth | - | - | - | $15,854 | 1,143 | $37,634,615 | Dec 29 | Picturehouse | false |
| 67 | Americanizing Shelley | - | - | - | $14,569 | 5 | $128,024 | Apr 26 | Rocky Mountain Pictures | false |
| 68 | Mafioso | - | - | - | $14,513 | 7 | $400,019 | Jan 19 | Rialto Pictures | false |
| 69 | Kickin' It Old Skool | - | - | - | $13,519 | 1,816 | $4,502,604 | Apr 27 | Yari Film Group Releasing | false |
| 70 | Offside | - | - | - | $13,398 | 17 | $180,530 | Mar 23 | Sony Pictures Classics | false |
| 71 | Private Property | - | - | - | $12,786 | 3 | $62,897 | May 18 | New Yorker Films | false |
| 72 | Life in a Metro | - | - | - | $12,031 | 35 | $150,212 | May 11 | UTV Motion Pictures | false |
| 73 | Severance | - | - | - | $11,737 | 34 | $137,221 | May 18 | Magnolia Pictures | false |
| 74 | Aqua Teen Hunger Force Colon Movie Film for Theaters | - | - | - | $11,556 | 877 | $5,520,368 | Apr 13 | First Look International | false |
| 75 | Romeo & Juliet: Sealed with a Kiss | - | - | - | $11,268 | 27 | $463,002 | Oct 27 | Indican Pictures | false |
| 76 | Red Road | - | - | - | $10,330 | 11 | $154,892 | Apr 13 | Tartan | false |
| 77 | Amu | - | - | - | $10,298 | 6 | $51,251 | May 25 | Emerging Pictures | false |
| 78 | The Boss of It All | - | - | - | $10,052 | 4 | $51,548 | May 23 | IFC Films | false |
| 79 | Sweet Land | - | - | - | $9,117 | 47 | $1,706,325 | Oct 13 | Libero | false |
| 80 | Even Money | - | - | - | $8,783 | 19 | $64,458 | May 18 | Yari Film Group Releasing | false |
| 81 | The Italian | - | - | - | $8,405 | 25 | $555,436 | Jan 19 | Sony Pictures Classics | false |
| 82 | Galapagos | - | - | - | $8,095 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 83 | The TV Set | - | - | - | $7,828 | 19 | $265,198 | Apr 6 | THINKFilm | false |
| 84 | Zoo | - | - | - | $7,329 | 5 | $69,770 | Apr 25 | THINKFilm | false |
| 85 | The Host | - | - | - | $7,154 | 116 | $2,201,923 | Mar 9 | Magnolia Pictures | false |
| 86 | Journey from the Fall | - | - | - | $6,667 | 14 | $641,039 | Mar 23 | ImaginAsian Pictures | false |
| 87 | T-Rex: Back to the Cretaceous | - | - | - | $6,149 | 38 | $53,354,743 | Oct 23 | IMAX | false |
| 88 | Killer of Sheep | - | - | - | $5,601 | 9 | $404,508 | Mar 30 | Milestone | false |
| 89 | Poison Friends | - | - | - | $5,540 | 2 | $13,665 | Apr 27 | Strand Releasing | false |
| 90 | I Have Never Forgotten You: The Life & Legacy of Simon Wiesenthal | - | - | - | $5,075 | 9 | $29,976 | May 23 | Luminous Velocity Releasing | false |
| 91 | Brand Upon the Brain! | - | - | - | $4,549 | 7 | $263,200 | May 9 | Vitagraph Films | false |
| 92 | Day Night Day Night | - | - | - | $4,286 | 6 | $31,856 | May 9 | IFC Films | false |
| 93 | Private Fears in Public Places | - | - | - | $3,418 | 6 | $134,636 | Apr 13 | IFC Films | false |
| 94 | Snow Cake | - | - | - | $3,418 | 12 | $26,651 | Apr 27 | IFC Films | false |
| 95 | L'iceberg | - | - | - | $3,301 | 3 | $19,789 | May 4 | First Run | false |
| 96 | The Page Turner | - | - | - | $2,340 | 15 | $209,659 | Mar 23 | Tartan | false |
| 97 | Civic Duty | - | - | - | $2,029 | 56 | $95,953 | May 4 | Freestyle Releasing | false |
| 98 | The Treatment | - | - | - | $2,003 | 3 | $83,354 | May 4 | New Yorker Films | false |
| 99 | Air Guitar Nation | - | - | - | $1,846 | 10 | $71,471 | Mar 23 | Shadow Distribution | false |
| 100 | Aliens of the Deep | - | - | - | $1,779 | 27 | $8,968,684 | Jan 28 | Walt Disney Studios Motion Pictures | false |
| 101 | Alice Neel | - | - | - | $1,753 | 1 | $48,969 | Apr 20 | SeeThink Films | false |
| 102 | I Don't Want to Sleep Alone | - | - | - | $1,717 | 1 | $19,292 | May 9 | Strand Releasing | false |
| 103 | El Topo | - | - | - | $1,527 | 4 | $80,302 | Dec 13 | ABKCO Films | false |
| 104 | The Holy Mountain | - | - | - | $1,527 | 3 | $61,001 | Jan 19 | ABKCO Films | false |
| 105 | First Snow | - | - | - | $1,352 | 33 | $214,864 | Mar 23 | Yari Film Group Releasing | false |
| 106 | The Rules of the Game | - | - | - | $1,323 | 5 | $273,641 | Oct 27 | Janus Films | false |
| 107 | I Think I Love My Wife | - | - | - | $1,307 | 1,794 | $12,550,605 | Mar 16 | Fox Searchlight Pictures | false |
| 108 | Steel City | - | - | - | $1,213 | 3 | $10,227 | May 25 | Truly Indie | false |
| 109 | Boy Culture | - | - | - | $1,152 | 7 | $220,409 | Mar 23 | TLA Releasing | false |
| 110 | Iraq in Fragments | - | - | - | $756 | 12 | $204,462 | Nov 8 | Arab Film Distribution | false |
| 111 | Flanders | - | - | - | $623 | 2 | $22,788 | May 18 | International Film Circuit | false |
| 112 | Puccini for Beginners | - | - | - | $497 | 11 | $89,464 | Feb 2 | Strand Releasing | false |
| 113 | Grbavica | - | - | - | $389 | 3 | $43,460 | Feb 16 | Strand Releasing | false |
| 114 | Allegro | - | - | - | $352 | 1 | $7,404 | May 9 | International Film Circuit | false |
| 115 | Gringo Wedding | - | - | - | $300 | 10 | $26,946 | May 4 | Gringo Wedding | false |
| 116 | Climates | - | - | - | $203 | 7 | $119,958 | Oct 27 | Zeitgeist Films | false |
| 117 | The Situation | - | - | - | $154 | 7 | $48,896 | Feb 2 | Shadow Distribution | false |
