| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | X-Men: The Last Stand | - | - | - | $122,861,157 | 3,714 | $234,362,462 | May 26 | Twentieth Century Fox | false |
| 2 | The Da Vinci Code | - | - | - | $42,437,372 | 3,757 | $217,536,138 | May 19 | Sony Pictures Releasing | false |
| 3 | Over the Hedge | - | - | - | $35,322,115 | 4,093 | $155,019,340 | May 19 | DreamWorks | false |
| 4 | Mission: Impossible III | - | - | - | $8,901,106 | 4,059 | $134,029,801 | May 5 | Paramount Pictures | false |
| 5 | Poseidon | - | - | - | $7,087,413 | 3,555 | $60,674,817 | May 12 | Warner Bros. | false |
| 6 | RV | - | - | - | $5,446,703 | 3,651 | $71,726,025 | Apr 28 | Sony Pictures Releasing | false |
| 7 | See No Evil | - | - | - | $3,437,537 | 1,270 | $15,032,800 | May 19 | Lionsgate | false |
| 8 | Just My Luck | - | - | - | $2,480,284 | 2,543 | $17,326,650 | May 12 | Twentieth Century Fox | false |
| 9 | United 93 | - | - | - | $1,054,560 | 1,871 | $31,483,450 | Apr 28 | Universal Pictures | false |
| 10 | Ice Age 2: The Meltdown | - | - | - | $985,778 | 3,969 | $195,330,621 | Mar 31 | Twentieth Century Fox | false |
| 11 | An American Haunting | - | - | - | $909,568 | 1,703 | $16,298,046 | May 5 | Freestyle Releasing | false |
| 12 | Akeelah and the Bee | - | - | - | $902,487 | 2,195 | $18,848,430 | Apr 28 | Lionsgate | false |
| 13 | Fanaa | - | - | - | $878,938 | 72 | $2,105,352 | May 26 | Yash Raj Films | false |
| 14 | Keeping Up with the Steins | - | - | - | $708,972 | 163 | $4,339,241 | May 12 | Miramax | false |
| 15 | The Sentinel | - | - | - | $635,378 | 2,851 | $36,280,697 | Apr 21 | Twentieth Century Fox | false |
| 16 | Thank You for Smoking | - | - | - | $594,770 | 1,020 | $24,793,509 | Mar 17 | Fox Searchlight Pictures | false |
| 17 | Friends with Money | - | - | - | $500,958 | 1,010 | $13,368,437 | Apr 7 | Sony Pictures Classics | false |
| 18 | Stick It | - | - | - | $474,757 | 2,044 | $26,910,736 | Apr 28 | Walt Disney Studios Motion Pictures | false |
| 19 | Deep Sea | - | - | - | $446,035 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 20 | Scary Movie 4 | - | - | - | $419,670 | 3,674 | $90,710,620 | Apr 14 | Dimension Films | false |
| 21 | Water 2006 Re-release | - | - | - | $395,743 | 91 | $3,278,815 | Apr 28 | Fox Searchlight Pictures | false |
| 22 | An Inconvenient Truth | - | - | - | $367,311 | 587 | $24,146,161 | May 24 | Paramount Classics | false |
| 23 | The Lost City | - | - | - | $277,443 | 56 | $2,484,186 | Apr 28 | Magnolia Pictures | false |
| 24 | Art School Confidential | - | - | - | $275,090 | 762 | $3,297,137 | May 5 | Sony Pictures Classics | false |
| 25 | Failure to Launch | - | - | - | $270,311 | 3,202 | $88,715,192 | Mar 10 | Paramount Pictures | false |
| 26 | Goal! The Dream Begins | - | - | - | $263,202 | 1,007 | $4,283,255 | May 12 | Walt Disney Studios Motion Pictures | false |
| 27 | Silent Hill | - | - | - | $253,561 | 2,932 | $46,982,632 | Apr 21 | Sony Pictures Releasing | false |
| 28 | Hoot | - | - | - | $247,761 | 3,018 | $8,117,637 | May 5 | New Line Cinema | false |
| 29 | Inside Man | - | - | - | $232,090 | 2,867 | $88,513,495 | Mar 24 | Universal Pictures | false |
| 30 | The Proposition | - | - | - | $231,425 | 200 | $1,903,434 | May 5 | First Look International | false |
| 31 | The Shaggy Dog | - | - | - | $225,231 | 3,501 | $61,123,569 | Mar 10 | Walt Disney Studios Motion Pictures | false |
| 32 | Kinky Boots | - | - | - | $202,025 | 127 | $1,822,428 | Apr 14 | Miramax | false |
| 33 | V for Vendetta | - | - | - | $175,499 | 3,365 | $70,511,035 | Mar 17 | Warner Bros. | false |
| 34 | She's the Man | - | - | - | $147,457 | 2,631 | $33,741,133 | Mar 17 | DreamWorks | false |
| 35 | Magnificent Desolation: Walking on the Moon | - | - | - | $136,525 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 36 | Take the Lead | - | - | - | $130,842 | 3,009 | $34,742,066 | Apr 7 | New Line Cinema | false |
| 37 | The Wild | - | - | - | $114,495 | 2,854 | $37,384,046 | Apr 14 | Walt Disney Studios Motion Pictures | false |
| 38 | Brick | - | - | - | $101,950 | 45 | $2,075,743 | Mar 31 | Focus Features | false |
| 39 | Down in the Valley | - | - | - | $83,698 | 28 | $568,932 | May 5 | THINKFilm | false |
| 40 | The Notorious Bettie Page | - | - | - | $80,515 | 73 | $1,415,082 | Apr 14 | Picturehouse | false |
| 41 | Stay Alive | - | - | - | $75,165 | 2,009 | $23,086,480 | Mar 24 | Walt Disney Studios Motion Pictures | false |
| 42 | Lucky Number Slevin | - | - | - | $72,641 | 1,989 | $22,495,466 | Apr 7 | Metro-Goldwyn-Mayer (MGM) | false |
| 43 | Mrs Palfrey at the Claremont | - | - | - | $64,800 | 22 | $1,720,953 | Nov 25 | Cineville | false |
| 44 | American Masters: Sketches of Frank Gehry | - | - | - | $56,897 | 21 | $439,309 | May 12 | Sony Pictures Classics | false |
| 45 | Eight Below | - | - | - | $54,487 | 3,122 | $81,612,565 | Feb 17 | Walt Disney Studios Motion Pictures | false |
| 46 | Wild Safari - A South African Adventure | - | - | - | $54,365 | 21 | $16,621,530 | Apr 8 | nWave Pictures | false |
| 47 | Roving Mars | - | - | - | $54,276 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 48 | Army of Shadows | - | - | - | $46,104 | 8 | $741,766 | Apr 28 | Rialto Pictures | false |
| 49 | Wah-Wah | - | - | - | $45,169 | 26 | $234,750 | May 12 | IDP Distribution | false |
| 50 | Hard Candy | - | - | - | $43,838 | 152 | $1,024,640 | Apr 14 | Lionsgate | false |
| 51 | The Celestine Prophecy | - | - | - | $37,665 | 19 | $617,236 | Apr 19 | RAM Entertainment | false |
| 52 | The Promise | - | - | - | $37,661 | 213 | $669,625 | May 5 | Warner Independent Pictures (WIP) | false |
| 53 | The Child | - | - | - | $31,196 | 40 | $651,941 | Mar 24 | Sony Pictures Classics | false |
| 54 | The Hills Have Eyes | - | - | - | $29,256 | 2,621 | $41,778,863 | Mar 10 | Fox Searchlight Pictures | false |
| 55 | Galapagos | - | - | - | $26,268 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 56 | Phat Girlz | - | - | - | $26,124 | 1,060 | $7,061,128 | Apr 7 | Fox Searchlight Pictures | false |
| 57 | Date Movie | - | - | - | $24,884 | 2,898 | $48,548,426 | Feb 17 | Twentieth Century Fox | false |
| 58 | Russian Dolls | - | - | - | $24,027 | 11 | $326,095 | May 10 | IFC Films | false |
| 59 | Sophie Scholl: The Final Days | - | - | - | $20,291 | 28 | $680,331 | Feb 17 | Zeitgeist Films | false |
| 60 | The Three Burials of Melquiades Estrada | - | - | - | $19,766 | 356 | $5,027,684 | Dec 14 | Sony Pictures Classics | false |
| 61 | Don't Come Knocking | - | - | - | $19,499 | 32 | $440,793 | Mar 17 | Sony Pictures Classics | false |
| 62 | Boynton Beach Club | - | - | - | $18,042 | 65 | $3,127,472 | Mar 17 | - | false |
| 63 | 12 and Holding | - | - | - | $17,789 | 15 | $96,464 | May 19 | IFC Films | false |
| 64 | Lady Vengeance | - | - | - | $17,760 | 15 | $211,667 | Apr 28 | Tartan | false |
| 65 | Mountain Patrol 2006 Re-release | - | - | - | $17,365 | 11 | $143,383 | Apr 14 | IDP Distribution | false |
| 66 | The World's Fastest Indian | - | - | - | $17,323 | 251 | $5,128,124 | Dec 7 | Magnolia Pictures | false |
| 67 | Lemming | - | - | - | $16,617 | 4 | $81,698 | May 19 | Strand Releasing | false |
| 68 | Cavite | - | - | - | $16,124 | 3 | $70,071 | May 26 | Truly Indie | false |
| 69 | Big Momma's House 2 | - | - | - | $14,616 | 3,261 | $70,165,972 | Jan 27 | Twentieth Century Fox | false |
| 70 | Clean | - | - | - | $14,533 | 8 | $138,711 | Apr 28 | Palm Pictures | false |
| 71 | Tsotsi | - | - | - | $14,253 | 122 | $2,912,606 | Feb 24 | Miramax | false |
| 72 | The Moustache | - | - | - | $11,758 | 6 | $244,771 | May 24 | The Cinema Guild | false |
| 73 | Stolen | - | - | - | $11,399 | 5 | $132,596 | Apr 19 | International Film Circuit | false |
| 74 | The King | - | - | - | $10,622 | 16 | $282,183 | May 19 | THINKFilm | false |
| 75 | Syrian Bride | - | - | - | $9,741 | 4 | $380,505 | Nov 16 | Koch Lorber Films | false |
| 76 | C.S.A.: The Confederate States of America | - | - | - | $9,465 | 28 | $672,156 | Oct 7 | IFC Films | false |
| 77 | The Beauty Academy of Kabul | - | - | - | $9,357 | 13 | $225,448 | Nov 4 | Shadow Distribution | false |
| 78 | Drawing Restraint 9 | - | - | - | $8,878 | 5 | $234,743 | Mar 29 | IFC Films | false |
| 79 | Joyeux Noel | - | - | - | $8,714 | 53 | $1,054,361 | Dec 16 | Sony Pictures Classics | false |
| 80 | Somersault 2006 Re-release | - | - | - | $8,440 | 7 | $92,214 | Apr 21 | Magnolia Pictures | false |
| 81 | Neil Young: Heart of Gold | - | - | - | $6,405 | 65 | $1,904,606 | Feb 10 | Paramount Classics | false |
| 82 | Aliens of the Deep | - | - | - | $6,295 | 27 | $8,968,684 | Jan 28 | Walt Disney Studios Motion Pictures | false |
| 83 | T-Rex: Back to the Cretaceous | - | - | - | $6,126 | 38 | $53,354,743 | Oct 23 | IMAX | false |
| 84 | Transamerica | - | - | - | $6,039 | 656 | $9,015,303 | Dec 2 | The Weinstein Company | false |
| 85 | Sir! No Sir! | - | - | - | $5,634 | 7 | $116,944 | Apr 7 | Balcony Releasing | false |
| 86 | Three Times | - | - | - | $5,270 | 5 | $151,922 | Apr 26 | IFC Films | false |
| 87 | Mrs. Henderson Presents | - | - | - | $5,242 | 522 | $11,036,366 | Dec 9 | The Weinstein Company | false |
| 88 | I Am a Sex Addict | - | - | - | $5,240 | 9 | $115,694 | Apr 5 | IFC Films | false |
| 89 | Haunted Castle | - | - | - | $5,025 | 10 | $13,651,656 | Feb 23 | nWave Pictures | false |
| 90 | Moonlight | - | - | - | $4,896 | 2 | $51,570 | May 19 | Indican Pictures | false |
| 91 | Shem | - | - | - | $4,892 | 2 | $14,804 | May 26 | HP Releasing | false |
| 92 | Space Station 3D | - | - | - | $4,641 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 93 | Church Ball | - | - | - | $4,552 | 40 | $464,991 | Mar 17 | Halestone Distribution | false |
| 94 | Pulse: A Stomp Odyssey | - | - | - | $4,500 | 16 | $10,086,514 | Oct 11 | Giant Screen Films | false |
| 95 | Adam & Steve | - | - | - | $4,484 | 17 | $309,404 | Mar 31 | TLA Releasing | false |
| 96 | The Devil and Daniel Johnston | - | - | - | $4,082 | 17 | $334,450 | Mar 31 | Sony Pictures Classics | false |
| 97 | Marilyn Hotchkiss' Ballroom Dancing & Charm School | - | - | - | $4,063 | 46 | $349,132 | Mar 31 | IDP Distribution | false |
| 98 | Summer Storm | - | - | - | $3,825 | 10 | $95,204 | Mar 17 | Regent Releasing | false |
| 99 | The Fallen Idol | - | - | - | $3,411 | 4 | $141,502 | Feb 10 | Rialto Pictures | false |
| 100 | Our Brand Is Crisis | - | - | - | $3,050 | 2 | $166,750 | Mar 1 | Koch Lorber Films | false |
| 101 | Sisters in Law | - | - | - | $2,881 | 2 | $33,312 | Apr 12 | Women Make Movies | false |
| 102 | Unidentified | - | - | - | $2,630 | 24 | $224,099 | Apr 28 | Five & Two Pictures | false |
| 103 | Guys and Balls 2006 Re-release | - | - | - | $2,189 | 7 | $28,324 | Apr 28 | Regent Releasing | false |
| 104 | The Big Risk | - | - | - | $1,990 | 2 | $95,413 | Nov 18 | Rialto Pictures | false |
| 105 | 2005 Academy Award Nominated Short Films | - | - | - | $1,733 | 12 | $157,415 | Feb 24 | Magnolia Pictures | false |
| 106 | Giuliani Time | - | - | - | $1,450 | 2 | $21,967 | May 12 | Cinema Libre Studio | false |
| 107 | La petite Jérusalem | - | - | - | $1,441 | 5 | $53,580 | Jan 27 | Kino International | false |
| 108 | The Death of Mr. Lazarescu | - | - | - | $1,290 | 5 | $80,301 | Apr 26 | Tartan | false |
| 109 | Nine Lives | - | - | - | $1,228 | 33 | $478,830 | Oct 14 | Magnolia Pictures | false |
| 110 | Dead Man's Shoes 2006 Re-release | - | - | - | $1,125 | 2 | $6,408 | May 12 | Magnolia Pictures | false |
| 111 | Lonesome Jim | - | - | - | $1,006 | 16 | $154,187 | Mar 24 | IFC Films | false |
| 112 | Iron Island | - | - | - | $992 | 4 | $27,177 | Mar 31 | Kino International | false |
| 113 | Take My Eyes 2006 Re-release | - | - | - | $974 | 2 | $30,496 | Mar 17 | New Yorker Films | false |
| 114 | Ballets Russes | - | - | - | $900 | 21 | $815,848 | Oct 26 | Zeitgeist Films | false |
| 115 | Alien Adventure | - | - | - | $900 | 10 | $8,959,784 | Aug 20 | nWave Pictures | false |
| 116 | Encounter in the Third Dimension | - | - | - | $830 | 16 | $7,195,792 | Feb 26 | nWave Pictures | false |
| 117 | Mongolian Ping Pong | - | - | - | $684 | 5 | $71,223 | Apr 21 | First Run | false |
| 118 | Yang Ban Xi: The 8 Modelworks | - | - | - | $675 | 2 | $21,244 | Feb 8 | Shadow Distribution | false |
| 119 | Night Watch 2005 Re-release | - | - | - | $565 | 158 | $1,502,188 | Feb 17 | Fox Searchlight Pictures | false |
| 120 | Touch the Sound: A Sound Journey with Evelyn Glennie | - | - | - | $450 | 9 | $176,801 | Sep 7 | Shadow Distribution | false |
| 121 | Free Zone | - | - | - | $340 | 2 | $32,381 | Apr 7 | New Yorker Films | false |
| 122 | The Keeper: The Legend of Omar Khayyam | - | - | - | $310 | 5 | $225,863 | Jun 10 | Arrival Pictures | false |
| 123 | American Gun | - | - | - | $297 | 6 | $24,098 | Mar 22 | IFC Films | false |
| 124 | Forgiving Dr. Mengele | - | - | - | $212 | 1 | $10,403 | Feb 24 | First Run | false |
| 125 | Screen Door Jesus | - | - | - | $158 | 3 | $59,000 | Sep 30 | Indican Pictures | false |
