| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Hangover Part II | - | - | - | $17,480,581 | 3,675 | $254,464,305 | May 26 | Warner Bros. | false |
| 2 | Kung Fu Panda 2 | - | - | - | $13,214,873 | 3,952 | $165,249,063 | May 26 | DreamWorks | false |
| 3 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $10,183,364 | 4,164 | $241,071,802 | May 20 | Walt Disney Studios Motion Pictures | false |
| 4 | Bridesmaids | - | - | - | $4,185,555 | 2,958 | $169,106,725 | May 13 | Universal Pictures | false |
| 5 | Thor | - | - | - | $2,546,271 | 3,963 | $181,030,624 | May 6 | Paramount Pictures | false |
| 6 | Fast Five | - | - | - | $1,490,500 | 3,793 | $209,837,675 | Apr 29 | Universal Pictures | false |
| 7 | Rio | - | - | - | $638,688 | 3,842 | $143,619,809 | Apr 15 | Twentieth Century Fox | false |
| 8 | Midnight in Paris | - | - | - | $625,648 | 1,038 | $56,817,045 | May 20 | Sony Pictures Classics | false |
| 9 | Jumping the Broom | - | - | - | $561,805 | 2,035 | $37,295,394 | May 6 | TriStar Pictures | false |
| 10 | Something Borrowed | - | - | - | $417,337 | 2,904 | $39,046,489 | May 6 | Warner Bros. | false |
| 11 | Priest | - | - | - | $412,736 | 2,864 | $29,137,000 | May 13 | Screen Gems | false |
| 12 | Water for Elephants | - | - | - | $287,463 | 2,820 | $58,709,717 | Apr 22 | Twentieth Century Fox | false |
| 13 | Cave of Forgotten Dreams | - | - | - | $146,154 | 123 | $5,304,920 | Apr 29 | IFC Films | false |
| 14 | Soul Surfer | - | - | - | $131,861 | 2,240 | $43,853,424 | Apr 8 | TriStar Pictures | false |
| 15 | The Tree of Life | - | - | - | $120,868 | 237 | $13,303,319 | May 27 | Fox Searchlight Pictures | false |
| 16 | Madea's Big Happy Family | - | - | - | $97,839 | 2,288 | $53,345,287 | Apr 22 | Lionsgate | false |
| 17 | Rango | - | - | - | $96,150 | 3,923 | $123,477,607 | Mar 4 | Paramount Pictures | false |
| 18 | Source Code | - | - | - | $81,448 | 2,971 | $54,712,227 | Apr 1 | Summit Entertainment | false |
| 19 | Everything Must Go | - | - | - | $80,887 | 245 | $2,711,643 | May 13 | Roadside Attractions | false |
| 20 | Born to Be Wild | - | - | - | $61,592 | 208 | $25,978,556 | Apr 8 | Warner Bros. | false |
| 21 | Hop | - | - | - | $59,785 | 3,616 | $108,085,305 | Apr 1 | Universal Pictures | false |
| 22 | Hanna | - | - | - | $55,922 | 2,545 | $40,259,119 | Apr 8 | Focus Features | false |
| 23 | Limitless | - | - | - | $51,953 | 2,838 | $79,249,455 | Mar 18 | Relativity Media | false |
| 24 | Win Win | - | - | - | $50,125 | 388 | $10,179,275 | Mar 18 | Fox Searchlight Pictures | false |
| 25 | Jane Eyre | - | - | - | $47,470 | 319 | $11,242,660 | Mar 11 | Focus Features | false |
| 26 | The Lincoln Lawyer | - | - | - | $47,020 | 2,707 | $58,009,200 | Mar 18 | Lionsgate | false |
| 27 | The Conspirator | - | - | - | $45,578 | 849 | $11,538,204 | Apr 15 | Roadside Attractions | false |
| 28 | Diary of a Wimpy Kid: Rodrick Rules | - | - | - | $44,202 | 3,169 | $52,698,535 | Mar 25 | Twentieth Century Fox | false |
| 29 | Insidious | - | - | - | $33,368 | 2,419 | $54,009,150 | Apr 1 | FilmDistrict | false |
| 30 | Scream 4 | - | - | - | $29,609 | 3,314 | $38,180,928 | Apr 15 | Dimension Films | false |
| 31 | Hubble | - | - | - | $28,954 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 32 | The Beaver | - | - | - | $26,883 | 168 | $970,816 | May 6 | Summit Entertainment | false |
| 33 | African Cats | - | - | - | $26,663 | 1,224 | $15,428,747 | Apr 22 | Walt Disney Studios Motion Pictures | false |
| 34 | Mars Needs Moms | - | - | - | $25,861 | 3,117 | $21,392,758 | Mar 11 | Walt Disney Studios Motion Pictures | false |
| 35 | Gnomeo & Juliet | - | - | - | $24,085 | 3,037 | $99,967,670 | Feb 11 | Walt Disney Studios Motion Pictures | false |
| 36 | Hoodwinked Too! Hood vs. Evil | - | - | - | $23,112 | 2,505 | $10,143,779 | Apr 29 | The Weinstein Company | false |
| 37 | Battle Los Angeles | - | - | - | $14,778 | 3,417 | $83,552,429 | Mar 11 | Sony Pictures Releasing | false |
| 38 | Prom | - | - | - | $11,372 | 2,730 | $10,130,219 | Apr 29 | Walt Disney Studios Motion Pictures | false |
| 39 | Arthur | - | - | - | $10,957 | 3,276 | $33,035,397 | Apr 8 | Warner Bros. | false |
| 40 | I Am Number Four | - | - | - | $6,801 | 3,156 | $55,100,437 | Feb 18 | Walt Disney Studios Motion Pictures | false |
| 41 | Tangled | - | - | - | $3,953 | 3,603 | $200,821,936 | Nov 24 | Walt Disney Studios Motion Pictures | false |
| 42 | 35 and Ticking | - | - | - | $3,871 | 6 | $113,794 | May 20 | Image Entertainment | false |
| 43 | The King's Speech PG-13 Version | - | - | - | $3,259 | 1,011 | $3,344,306 | Apr 1 | The Weinstein Company | false |
| 44 | Went the Day Well? | - | - | - | $3,044 | 1 | $47,214 | May 20 | Rialto Pictures | false |
| 45 | Kill the Irishman | - | - | - | $2,440 | 56 | $1,188,194 | Mar 11 | Anchor Bay Films | false |
| 46 | Biutiful | - | - | - | $912 | 191 | $5,101,237 | Jan 28 | Roadside Attractions | false |
| 47 | Nostalgia for the Light | - | - | - | $901 | 6 | $163,962 | Jan 13 | Icarus Films | false |
| 48 | Go for It! | - | - | - | $575 | 218 | $180,237 | May 13 | Lionsgate | false |
| 49 | Dum Maaro Dum | - | - | - | $418 | 101 | $564,489 | Apr 22 | Fox Searchlight Pictures | false |
| 50 | The Music Never Stopped | - | - | - | $373 | 33 | $258,223 | Mar 18 | Roadside Attractions | false |
| 51 | Skateland | - | - | - | $133 | 11 | $19,411 | May 13 | Freestyle Releasing | false |
| 52 | The Topp Twins: Untouchable Girls 2011 Re-release | - | - | - | $115 | 5 | $29,316 | May 13 | Argot Pictures | false |
