| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The American | - | - | - | $16,662,333 | 2,833 | $35,606,376 | Sep 1 | Focus Features | false |
| 2 | Machete | - | - | - | $14,102,888 | 2,678 | $26,593,646 | Sep 3 | Twentieth Century Fox | false |
| 3 | Takers | - | - | - | $13,535,992 | 2,206 | $57,744,720 | Aug 27 | Screen Gems | false |
| 4 | The Last Exorcism | - | - | - | $8,750,191 | 2,874 | $41,034,350 | Aug 27 | Lionsgate | false |
| 5 | Going the Distance | - | - | - | $8,508,290 | 3,030 | $17,804,299 | Sep 3 | Warner Bros. | false |
| 6 | The Expendables | - | - | - | $8,317,824 | 3,398 | $103,068,524 | Aug 13 | Lionsgate | false |
| 7 | The Other Guys | - | - | - | $6,664,628 | 3,651 | $119,219,978 | Aug 6 | Sony Pictures Releasing | false |
| 8 | Eat Pray Love | - | - | - | $6,175,610 | 3,108 | $80,574,010 | Aug 13 | Sony Pictures Releasing | false |
| 9 | Inception | - | - | - | $5,884,355 | 3,792 | $292,576,195 | Jul 16 | Warner Bros. | false |
| 10 | Nanny McPhee Returns | - | - | - | $4,806,685 | 2,798 | $29,011,215 | Aug 20 | Universal Pictures | false |
| 11 | Despicable Me | - | - | - | $4,047,680 | 3,602 | $251,639,815 | Jul 9 | Universal Pictures | false |
| 12 | Vampires Suck | - | - | - | $3,941,945 | 3,233 | $36,661,504 | Aug 18 | Twentieth Century Fox | false |
| 13 | The Switch | - | - | - | $3,917,061 | 2,017 | $27,779,426 | Aug 20 | Miramax | false |
| 14 | Piranha 3D | - | - | - | $3,010,152 | 2,491 | $25,003,155 | Aug 20 | Dimension Films | false |
| 15 | Avatar 2010 Special Edition | - | - | - | $2,961,801 | 812 | $10,741,486 | Aug 27 | Twentieth Century Fox | false |
| 16 | Toy Story 3 | - | - | - | $2,735,035 | 4,028 | $415,004,880 | Jun 18 | Walt Disney Studios Motion Pictures | false |
| 17 | Lottery Ticket | - | - | - | $2,717,275 | 1,974 | $24,719,879 | Aug 20 | Warner Bros. | false |
| 18 | Scott Pilgrim vs. the World | - | - | - | $1,985,220 | 2,820 | $31,657,980 | Aug 13 | Universal Pictures | false |
| 19 | Salt | - | - | - | $1,600,665 | 3,612 | $118,311,368 | Jul 23 | Sony Pictures Releasing | false |
| 20 | Get Low | - | - | - | $1,561,454 | 570 | $9,176,933 | Jul 30 | Sony Pictures Classics | false |
| 21 | Dinner for Schmucks | - | - | - | $1,275,303 | 3,046 | $73,026,337 | Jul 30 | DreamWorks | false |
| 22 | Step Up 3D | - | - | - | $995,485 | 2,439 | $42,400,223 | Aug 6 | Walt Disney Studios Motion Pictures | false |
| 23 | Grown Ups | - | - | - | $747,050 | 3,534 | $162,001,186 | Jun 25 | Sony Pictures Releasing | false |
| 24 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $643,127 | 3,705 | $43,585,753 | Jul 30 | Warner Bros. | false |
| 25 | The Sorcerer's Apprentice | - | - | - | $600,448 | 3,504 | $63,150,991 | Jul 14 | Walt Disney Studios Motion Pictures | false |
| 26 | The Twilight Saga: Eclipse | - | - | - | $545,245 | 4,468 | $300,531,751 | Jun 30 | Summit Entertainment | false |
| 27 | The Kids Are All Right | - | - | - | $494,036 | 994 | $20,811,365 | Jul 9 | Focus Features | false |
| 28 | Mao's Last Dancer | - | - | - | $444,200 | 137 | $4,817,770 | Aug 20 | The Samuel Goldwyn Company | false |
| 29 | The Last Airbender | - | - | - | $420,220 | 3,203 | $131,772,187 | Jul 1 | Paramount Pictures | false |
| 30 | Hubble | - | - | - | $387,366 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 31 | Ramona and Beezus | - | - | - | $366,799 | 2,719 | $26,167,002 | Jul 23 | Twentieth Century Fox | false |
| 32 | We Are Family | - | - | - | $366,354 | 78 | $638,144 | Sep 3 | UTV Motion Pictures | false |
| 33 | The Karate Kid | - | - | - | $316,839 | 3,740 | $176,591,618 | Jun 11 | Sony Pictures Releasing | false |
| 34 | The Girl Who Played with Fire | - | - | - | $301,856 | 185 | $7,638,241 | Jul 9 | Music Box Films | false |
| 35 | Shrek Forever After | - | - | - | $248,302 | 4,386 | $238,736,787 | May 21 | DreamWorks | false |
| 36 | Cairo Time | - | - | - | $222,075 | 76 | $1,603,616 | Aug 6 | IFC Films | false |
| 37 | Charlie St. Cloud | - | - | - | $189,220 | 2,725 | $31,162,545 | Jul 30 | Universal Pictures | false |
| 38 | The Tillman Story | - | - | - | $179,480 | 28 | $802,535 | Aug 20 | The Weinstein Company | false |
| 39 | Knight and Day 2010 Re-release | - | - | - | $164,150 | 3,104 | $76,423,035 | Jun 23 | Twentieth Century Fox | false |
| 40 | Animal Kingdom | - | - | - | $149,868 | 61 | $1,044,039 | Aug 13 | Sony Pictures Classics | false |
| 41 | Winter's Bone | - | - | - | $148,801 | 141 | $6,531,503 | Jun 11 | Roadside Attractions | false |
| 42 | What If... | - | - | - | $146,272 | 82 | $814,906 | Aug 20 | Five & Two Pictures | false |
| 43 | Mesrine: Killer Instinct 2010 Re-release | - | - | - | $120,299 | 34 | $551,697 | Aug 27 | Music Box Films | false |
| 44 | Predators | - | - | - | $113,825 | 2,669 | $52,000,688 | Jul 9 | Twentieth Century Fox | false |
| 45 | Mesrine: Public Enemy No. 1 2010 Re-release | - | - | - | $100,242 | 31 | $275,387 | Sep 3 | Music Box Films | false |
| 46 | I Am Love | - | - | - | $86,772 | 166 | $5,005,465 | Jun 18 | Magnolia Pictures | false |
| 47 | Under the Sea 3D | - | - | - | $84,253 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 48 | Prince of Persia: The Sands of Time | - | - | - | $70,422 | 3,646 | $90,759,676 | May 28 | Walt Disney Studios Motion Pictures | false |
| 49 | Flipped | - | - | - | $69,995 | 442 | $1,755,212 | Aug 6 | Warner Bros. | false |
| 50 | The A-Team | - | - | - | $66,915 | 3,544 | $77,222,099 | Jun 11 | Twentieth Century Fox | false |
| 51 | The Concert | - | - | - | $59,170 | 21 | $657,986 | Jul 30 | The Weinstein Company | false |
| 52 | Soul Kitchen | - | - | - | $53,761 | 23 | $276,901 | Aug 20 | IFC Films | false |
| 53 | The Wildest Dream | - | - | - | $48,697 | 21 | $898,137 | Aug 6 | National Geographic Entertainment | false |
| 54 | Marmaduke | - | - | - | $47,065 | 3,213 | $33,644,788 | Jun 4 | Twentieth Century Fox | false |
| 55 | Lebanon | - | - | - | $40,619 | 23 | $368,088 | Aug 6 | Sony Pictures Classics | false |
| 56 | Restrepo | - | - | - | $37,243 | 52 | $1,330,894 | Jun 25 | National Geographic Entertainment | false |
| 57 | Centurion | - | - | - | $37,174 | 19 | $123,570 | Aug 27 | Magnolia Pictures | false |
| 58 | Peepli Live | - | - | - | $36,403 | 70 | $757,951 | Aug 13 | UTV Motion Pictures | false |
| 59 | A Woman, a Gun and a Noodle Shop | - | - | - | $35,033 | 23 | $190,946 | Sep 3 | Sony Pictures Classics | false |
| 60 | The Extra Man | - | - | - | $30,001 | 33 | $453,377 | Jul 30 | Magnolia Pictures | false |
| 61 | Last Train Home | - | - | - | $24,207 | 14 | $288,328 | Sep 3 | Zeitgeist Films | false |
| 62 | The Girl with the Dragon Tattoo | - | - | - | $22,563 | 202 | $10,095,170 | Mar 19 | Music Box Films | false |
| 63 | Coco Chanel & Igor Stravinsky | - | - | - | $19,972 | 74 | $1,621,226 | Jun 11 | Sony Pictures Classics | false |
| 64 | Magnificent Desolation: Walking on the Moon | - | - | - | $18,476 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 65 | A Film Unfinished | - | - | - | $18,164 | 16 | $320,486 | Aug 18 | Oscilloscope | false |
| 66 | Cyrus | - | - | - | $17,524 | 454 | $7,468,936 | Jun 18 | Fox Searchlight Pictures | false |
| 67 | Agora | - | - | - | $16,063 | 17 | $619,423 | May 28 | Newmarket Films | false |
| 68 | Micmacs | - | - | - | $15,703 | 52 | $1,262,079 | May 28 | Sony Pictures Classics | false |
| 69 | Deep Sea | - | - | - | $15,323 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 70 | My Dog Tulip | - | - | - | $14,718 | 5 | $246,574 | Sep 1 | New Yorker Films | false |
| 71 | Exit Through the Gift Shop | - | - | - | $14,540 | 46 | $3,291,250 | Apr 16 | Producers Distribution Agency (PDA) | false |
| 72 | Jean-Michel Basquiat: The Radiant Child | - | - | - | $13,452 | 7 | $256,242 | Jul 21 | Arthouse Films | false |
| 73 | Solitary Man | - | - | - | $12,990 | 177 | $4,360,548 | May 21 | Anchor Bay Films | false |
| 74 | Le code a changé | - | - | - | $12,027 | 2 | $46,714 | Aug 27 | IFC Films | false |
| 75 | The Disappearance of Alice Creed | - | - | - | $11,540 | 12 | $166,980 | Aug 6 | Anchor Bay Films | false |
| 76 | La soga | - | - | - | $11,140 | 20 | $210,625 | Aug 13 | 7-57 Releasing | false |
| 77 | Joan Rivers: A Piece of Work | - | - | - | $10,161 | 115 | $2,930,687 | Jun 11 | IFC Films | false |
| 78 | The Secret in Their Eyes | - | - | - | $9,615 | 166 | $6,391,436 | Apr 16 | Sony Pictures Classics | false |
| 79 | Life During Wartime | - | - | - | $7,802 | 20 | $281,447 | Jul 23 | IFC Films | false |
| 80 | The Cremaster Cycle 2010 Re-release | - | - | - | $7,373 | 2 | $151,239 | Apr 9 | International Film Circuit | false |
| 81 | Date Night | - | - | - | $7,159 | 3,380 | $98,711,404 | Apr 9 | Twentieth Century Fox | false |
| 82 | Ondine | - | - | - | $7,104 | 39 | $550,472 | Jun 4 | Magnolia Pictures | false |
| 83 | White Wedding 2010 Re-release | - | - | - | $7,004 | 4 | $11,710 | Sep 3 | Dada Films | false |
| 84 | Wild Grass | - | - | - | $6,287 | 23 | $403,952 | Jun 25 | Sony Pictures Classics | false |
| 85 | Winnebago Man | - | - | - | $5,606 | 12 | $181,039 | Jul 9 | Kino International | false |
| 86 | The People I've Slept With | - | - | - | $5,172 | 2 | $19,137 | Aug 13 | - | false |
| 87 | Army of Crime | - | - | - | $4,518 | 3 | $37,031 | Aug 20 | Lorber Films | false |
| 88 | Metropolis 2010 Re-release | - | - | - | $4,301 | 9 | $529,603 | May 7 | Kino International | false |
| 89 | Dogtooth | - | - | - | $3,633 | 5 | $110,248 | Jun 25 | Kino International | false |
| 90 | Princess Kaiulani | - | - | - | $3,395 | 47 | $883,887 | May 14 | Roadside Attractions | false |
| 91 | Mademoiselle Chambon | - | - | - | $3,320 | 16 | $531,685 | May 28 | Lorber Films | false |
| 92 | Spoken Word | - | - | - | $3,022 | 4 | $32,961 | Jul 23 | Variance Films | false |
| 93 | The Milk of Sorrow | - | - | - | $3,022 | 2 | $10,462 | Aug 27 | Olive Films | false |
| 94 | Please Give | - | - | - | $2,887 | 272 | $4,033,574 | Apr 30 | Sony Pictures Classics | false |
| 95 | The Nature of Existence | - | - | - | $2,863 | 4 | $54,645 | Jun 18 | Walking Shadows | false |
| 96 | Ran 2010 Re-release | - | - | - | $2,816 | 4 | $124,673 | Feb 5 | Rialto Pictures | false |
| 97 | Mid-August Lunch | - | - | - | $2,414 | 23 | $675,299 | Mar 17 | Zeitgeist Films | false |
| 98 | Two in the Wave | - | - | - | $1,644 | 1 | $28,808 | May 19 | Lorber Films | false |
| 99 | Sea Monsters: A Prehistoric Adventure | - | - | - | $1,574 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 100 | Countdown to Zero | - | - | - | $1,444 | 28 | $272,040 | Jul 23 | Magnolia Pictures | false |
| 101 | Mother and Child | - | - | - | $1,214 | 119 | $1,110,509 | May 7 | Sony Pictures Classics | false |
| 102 | Le combat dans l'île | - | - | - | $1,113 | 1 | $50,039 | Jun 12 | The Film Desk | false |
| 103 | John Rabe | - | - | - | $1,109 | 6 | $67,519 | May 21 | Strand Releasing | false |
| 104 | The Sicilian Girl 2010 Re-release | - | - | - | $1,057 | 6 | $71,239 | Aug 4 | Music Box Films | false |
| 105 | Mississippi Mermaid | - | - | - | $1,005 | 1 | $33,216 | Jul 10 | The Film Desk | false |
| 106 | Circle | - | - | - | $977 | 2 | $10,024 | Aug 27 | Indican Pictures | false |
| 107 | Space Station 3D | - | - | - | $544 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 108 | Rosencrantz and Guildenstern Are Undead | - | - | - | $450 | 4 | $71,007 | Jun 4 | Indican Pictures | false |
| 109 | Everyone Else | - | - | - | $415 | 5 | $102,042 | Apr 9 | The Cinema Guild | false |
| 110 | Promised Lands | - | - | - | $196 | 1 | $4,546 | Feb 5 | The Film Desk | false |
| 111 | Neshoba | - | - | - | $88 | 2 | $19,245 | Aug 13 | First Run | false |
