| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The American | - | - | - | $3,484,543 | 2,833 | $35,606,376 | Sep 1 | Focus Features | false |
| 2 | Machete | - | - | - | $2,686,724 | 2,678 | $26,593,646 | Sep 3 | Twentieth Century Fox | false |
| 3 | Takers | - | - | - | $2,659,260 | 2,206 | $57,744,720 | Aug 27 | Screen Gems | false |
| 4 | The Expendables | - | - | - | $1,697,691 | 3,398 | $103,068,524 | Aug 13 | Lionsgate Films | false |
| 5 | Going the Distance | - | - | - | $1,623,326 | 3,030 | $17,804,299 | Sep 3 | Warner Bros. | false |
| 6 | The Last Exorcism | - | - | - | $1,408,215 | 2,874 | $41,034,350 | Aug 27 | Lionsgate Films | false |
| 7 | The Other Guys | - | - | - | $1,376,739 | 3,651 | $119,219,978 | Aug 6 | Sony Pictures Releasing | false |
| 8 | Eat Pray Love | - | - | - | $1,374,852 | 3,108 | $80,574,010 | Aug 13 | Sony Pictures Releasing | false |
| 9 | Inception | - | - | - | $1,312,106 | 3,792 | $292,576,195 | Jul 16 | Warner Bros. | false |
| 10 | Nanny McPhee Returns | - | - | - | $1,272,760 | 2,798 | $29,011,215 | Aug 20 | Universal Pictures | false |
| 11 | Despicable Me | - | - | - | $1,063,665 | 3,602 | $251,639,815 | Jul 9 | Universal Pictures | false |
| 12 | The Switch | - | - | - | $797,504 | 2,017 | $27,779,426 | Aug 20 | Miramax | false |
| 13 | Toy Story 3 | - | - | - | $790,234 | 4,028 | $415,004,880 | Jun 18 | Walt Disney Studios Motion Pictures | false |
| 14 | Vampires Suck | - | - | - | $745,778 | 3,233 | $36,661,504 | Aug 18 | Twentieth Century Fox | false |
| 15 | Avatar 2010 Special Edition | - | - | - | $704,206 | 812 | $10,741,486 | Aug 27 | Twentieth Century Fox | false |
| 16 | Piranha 3D | - | - | - | $577,894 | 2,491 | $25,003,155 | Aug 20 | - | false |
| 17 | Lottery Ticket | - | - | - | $565,887 | 1,974 | $24,719,879 | Aug 20 | Warner Bros. | false |
| 18 | Scott Pilgrim vs. the World | - | - | - | $431,745 | 2,820 | $31,524,275 | Aug 13 | Universal Pictures | false |
| 19 | Salt | - | - | - | $343,194 | 3,612 | $118,311,368 | Jul 23 | Sony Pictures Releasing | false |
| 20 | Dinner for Schmucks | - | - | - | $243,642 | 3,046 | $73,026,337 | Jul 30 | DreamWorks | false |
| 21 | Step Up 3D | - | - | - | $200,857 | 2,439 | $42,400,223 | Aug 6 | Walt Disney Studios Motion Pictures | false |
| 22 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $177,079 | 3,705 | $43,585,753 | Jul 30 | Warner Bros. | false |
| 23 | Grown Ups | - | - | - | $144,388 | 3,534 | $162,001,186 | Jun 25 | Sony Pictures Releasing | false |
| 24 | The Twilight Saga: Eclipse | - | - | - | $111,125 | 4,468 | $300,531,751 | Jun 30 | Summit Entertainment | false |
| 25 | Hubble | - | - | - | $109,247 | 151 | $52,522,904 | Mar 19 | Warner Bros. | false |
| 26 | Ramona and Beezus | - | - | - | $101,152 | 2,719 | $26,167,002 | Jul 23 | Twentieth Century Fox | false |
| 27 | The Kids Are All Right | - | - | - | $100,611 | 994 | $20,811,365 | Jul 9 | Focus Features | false |
| 28 | The Last Airbender | - | - | - | $98,732 | 3,203 | $131,772,187 | Jul 1 | Paramount Pictures | false |
| 29 | The Karate Kid | - | - | - | $70,707 | 3,740 | $176,591,618 | Jun 11 | Sony Pictures Releasing | false |
| 30 | We Are Family | - | - | - | $69,447 | 78 | $638,144 | Sep 3 | UTV Motion Pictures | false |
| 31 | Shrek Forever After | - | - | - | $52,944 | 4,386 | $238,736,787 | May 21 | DreamWorks | false |
| 32 | The Tillman Story | - | - | - | $43,081 | 28 | $802,535 | Aug 20 | The Weinstein Company | false |
| 33 | Charlie St. Cloud | - | - | - | $34,110 | 2,725 | $31,162,545 | Jul 30 | Universal Pictures | false |
| 34 | Winter's Bone | - | - | - | $31,403 | 141 | $6,531,503 | Jun 11 | Roadside Attractions | false |
| 35 | Knight and Day 2010 Re-release | - | - | - | $27,817 | 3,104 | $76,423,035 | Jun 23 | Twentieth Century Fox | false |
| 36 | Under the Sea 3D | - | - | - | $20,559 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 37 | Flipped | - | - | - | $19,090 | 442 | $1,755,212 | Aug 6 | Warner Bros. | false |
| 38 | The Concert | - | - | - | $14,170 | 21 | $657,986 | Jul 30 | The Weinstein Company | false |
| 39 | Predators | - | - | - | $13,513 | 2,669 | $52,000,688 | Jul 9 | Twentieth Century Fox | false |
| 40 | Marmaduke | - | - | - | $9,606 | 3,213 | $33,644,788 | Jun 4 | Twentieth Century Fox | false |
| 41 | The A-Team | - | - | - | $7,977 | 3,544 | $77,222,099 | Jun 11 | Twentieth Century Fox | false |
| 42 | Peepli Live | - | - | - | $6,708 | 70 | $757,951 | Aug 13 | UTV Motion Pictures | false |
| 43 | The Disappearance of Alice Creed | - | - | - | $2,652 | 12 | $166,980 | Aug 6 | Anchor Bay Films | false |
| 44 | Cyrus | - | - | - | $2,650 | 454 | $7,468,936 | Jun 18 | - | false |
| 45 | La soga | - | - | - | $2,440 | 20 | $210,625 | Aug 13 | 7-57 Releasing | false |
| 46 | Solitary Man | - | - | - | $2,238 | 177 | $4,360,548 | May 21 | Anchor Bay Films | false |
| 47 | Princess Kaiulani | - | - | - | $1,506 | 47 | $883,887 | May 14 | Roadside Attractions | false |
| 48 | The People I've Slept With | - | - | - | $1,229 | 2 | $19,137 | Aug 13 | - | false |
| 49 | White Wedding 2010 Re-release | - | - | - | $1,145 | 4 | $11,710 | Sep 3 | Dada Films | false |
