| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Tropic Thunder | - | - | - | $3,083,510 | 3,473 | $110,515,313 | Aug 13 | DreamWorks | false |
| 2 | The Dark Knight | - | - | - | $2,504,411 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 3 | Traitor | - | - | - | $2,137,862 | 2,108 | $23,530,831 | Aug 27 | Overture Films | false |
| 4 | Babylon A.D. | - | - | - | $2,056,944 | 3,425 | $22,532,572 | Aug 29 | Twentieth Century Fox | false |
| 5 | The House Bunny | - | - | - | $1,860,275 | 2,763 | $48,237,389 | Aug 22 | Sony Pictures Releasing | false |
| 6 | Death Race | - | - | - | $1,585,120 | 2,586 | $36,316,032 | Aug 22 | Universal Pictures | false |
| 7 | Mamma Mia! | - | - | - | $1,210,320 | 3,194 | $144,290,968 | Jul 18 | Universal Pictures | false |
| 8 | Disaster Movie | - | - | - | $1,108,562 | 2,642 | $14,190,901 | Aug 29 | Lionsgate | false |
| 9 | Star Wars: The Clone Wars | - | - | - | $1,053,265 | 3,452 | $35,161,554 | Aug 15 | Warner Bros. | false |
| 10 | Pineapple Express | - | - | - | $913,562 | 3,072 | $87,341,380 | Aug 6 | Sony Pictures Releasing | false |
| 11 | The Mummy: Tomb of the Dragon Emperor | - | - | - | $813,675 | 3,778 | $102,491,776 | Aug 1 | Universal Pictures | false |
| 12 | The Longshots | - | - | - | $730,757 | 2,089 | $11,537,046 | Aug 22 | Metro-Goldwyn-Mayer (MGM) | false |
| 13 | Vicky Cristina Barcelona | - | - | - | $710,464 | 726 | $23,216,709 | Aug 15 | Metro-Goldwyn-Mayer (MGM) | false |
| 14 | Journey to the Center of the Earth | - | - | - | $641,468 | 2,830 | $101,704,370 | Jul 11 | Warner Bros. | false |
| 15 | Mirrors | - | - | - | $575,552 | 2,664 | $30,691,439 | Aug 15 | Twentieth Century Fox | false |
| 16 | Fly Me to the Moon 3D | - | - | - | $541,447 | 713 | $13,816,982 | Aug 15 | Summit Entertainment | false |
| 17 | WALL·E | - | - | - | $473,860 | 3,992 | $223,808,164 | Jun 27 | Walt Disney Studios Motion Pictures | false |
| 18 | College | - | - | - | $466,621 | 2,124 | $4,694,636 | Aug 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 19 | The Sisterhood of the Traveling Pants 2 | - | - | - | $428,322 | 2,714 | $44,089,964 | Aug 6 | Warner Bros. | false |
| 20 | Hamlet 2 | - | - | - | $427,490 | 1,597 | $4,886,216 | Aug 22 | Focus Features | false |
| 21 | Step Brothers | - | - | - | $311,614 | 3,182 | $100,468,793 | Jul 25 | Sony Pictures Releasing | false |
| 22 | The Rocker | - | - | - | $210,958 | 2,784 | $6,409,528 | Aug 20 | Twentieth Century Fox | false |
| 23 | Kung Fu Panda | - | - | - | $170,835 | 4,136 | $215,727,546 | Jun 6 | DreamWorks | false |
| 24 | Hancock | - | - | - | $169,569 | 3,965 | $227,946,274 | Jul 2 | Sony Pictures Releasing | false |
| 25 | Bottle Shock | - | - | - | $165,766 | 401 | $4,078,607 | Aug 6 | Freestyle Releasing | false |
| 26 | Elegy | - | - | - | $165,647 | 142 | $3,581,642 | Aug 8 | The Samuel Goldwyn Company | false |
| 27 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $110,949 | 4,264 | $317,101,119 | May 22 | Paramount Pictures | false |
| 28 | Tell No One | - | - | - | $100,536 | 112 | $6,177,192 | Jul 2 | Music Box Films | false |
| 29 | Space Chimps | - | - | - | $84,189 | 2,538 | $30,105,968 | Jul 18 | Twentieth Century Fox | false |
| 30 | Brideshead Revisited | - | - | - | $66,237 | 501 | $6,432,256 | Jul 25 | Miramax | false |
| 31 | Iron Man | - | - | - | $53,520 | 4,154 | $318,604,126 | May 2 | Paramount Pictures | false |
| 32 | Hellboy II: The Golden Army | - | - | - | $45,900 | 3,212 | $75,986,503 | Jul 11 | Universal Pictures | false |
| 33 | Get Smart | - | - | - | $38,255 | 3,915 | $130,319,208 | Jun 20 | Warner Bros. | false |
| 34 | Wanted | - | - | - | $34,435 | 3,185 | $134,508,551 | Jun 27 | Universal Pictures | false |
| 35 | Goal II: Living the Dream | - | - | - | $29,334 | 99 | $225,067 | Aug 29 | Arenas Entertainment | false |
| 36 | You Don't Mess with the Zohan | - | - | - | $25,481 | 3,466 | $100,018,837 | Jun 6 | Sony Pictures Releasing | false |
| 37 | Henry Poole Is Here | - | - | - | $24,217 | 527 | $1,836,515 | Aug 15 | Overture Films | false |
| 38 | Kit Kittredge: An American Girl | - | - | - | $19,456 | 1,849 | $17,657,973 | Jun 20 | Picturehouse | false |
| 39 | The Incredible Hulk | - | - | - | $17,965 | 3,508 | $134,806,913 | Jun 13 | Universal Pictures | false |
| 40 | Sex and the City | - | - | - | $15,767 | 3,325 | $152,647,258 | May 30 | Warner Bros. | false |
| 41 | Bachna Ae Haseeno | - | - | - | $11,902 | 71 | $702,166 | Aug 15 | Yash Raj Films | false |
| 42 | Deep Sea | - | - | - | $10,824 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 43 | I.O.U.S.A. | - | - | - | $10,684 | 358 | $821,046 | Aug 22 | Roadside Attractions | false |
| 44 | The X Files: I Want to Believe | - | - | - | $9,751 | 3,185 | $20,982,478 | Jul 25 | Twentieth Century Fox | false |
| 45 | American Teen | - | - | - | $8,862 | 109 | $942,441 | Jul 25 | Paramount Vantage | false |
| 46 | Meet Dave | - | - | - | $8,840 | 3,011 | $11,803,254 | Jul 11 | Twentieth Century Fox | false |
| 47 | Beer for My Horses | - | - | - | $5,987 | 91 | $666,045 | Aug 8 | Roadside Attractions | false |
| 48 | The Visitor | - | - | - | $3,839 | 270 | $9,427,089 | Apr 11 | Overture Films | false |
| 49 | Mongol: The Rise of Genghis Khan | - | - | - | $2,166 | 253 | $5,705,761 | Jun 6 | Picturehouse | false |
| 50 | What Happens in Vegas | - | - | - | $2,027 | 3,255 | $80,277,646 | May 9 | Twentieth Century Fox | false |
| 51 | The Happening | - | - | - | $1,947 | 2,986 | $64,506,874 | Jun 13 | Twentieth Century Fox | false |
| 52 | The Fall | - | - | - | $905 | 111 | $2,266,905 | May 9 | Roadside Attractions | false |
| 53 | Before the Rains | - | - | - | $877 | 44 | $1,029,655 | May 9 | Roadside Attractions | false |
