| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Invincible | - | - | - | $3,275,944 | 2,987 | $57,806,952 | Aug 25 | Walt Disney Studios Motion Pictures | false |
| 2 | Crank | - | - | - | $2,439,268 | 2,515 | $27,838,408 | Sep 1 | Lionsgate Films | false |
| 3 | The Wicker Man | - | - | - | $2,130,031 | 2,784 | $23,649,127 | Sep 1 | Warner Bros. | false |
| 4 | Little Miss Sunshine | - | - | - | $2,005,086 | 1,602 | $59,891,098 | Jul 26 | - | false |
| 5 | The Illusionist | - | - | - | $1,771,008 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 6 | Barnyard | - | - | - | $1,697,423 | 3,311 | $72,637,803 | Aug 4 | Paramount Pictures | false |
| 7 | Talladega Nights: The Ballad of Ricky Bobby | - | - | - | $1,527,246 | 3,807 | $148,213,377 | Aug 4 | Sony Pictures Releasing | false |
| 8 | World Trade Center | - | - | - | $1,274,656 | 3,021 | $70,278,893 | Aug 9 | Paramount Pictures | false |
| 9 | Pirates of the Caribbean: Dead Man's Chest | - | - | - | $1,130,613 | 4,133 | $423,315,812 | Jul 7 | Walt Disney Studios Motion Pictures | false |
| 10 | Step Up | - | - | - | $1,106,032 | 2,647 | $65,328,121 | Aug 11 | Walt Disney Studios Motion Pictures | false |
| 11 | Accepted | - | - | - | $1,030,030 | 2,917 | $36,323,505 | Aug 18 | Universal Pictures | false |
| 12 | How to Eat Fried Worms | - | - | - | $1,010,014 | 1,870 | $13,040,527 | Aug 25 | New Line Cinema | false |
| 13 | Beerfest | - | - | - | $927,019 | 2,964 | $19,185,184 | Aug 25 | Warner Bros. | false |
| 14 | Idlewild | - | - | - | $662,875 | 975 | $12,571,185 | Aug 25 | Universal Pictures | false |
| 15 | Crossover | - | - | - | $634,556 | 1,023 | $7,009,668 | Sep 1 | Sony Pictures Releasing | false |
| 16 | Snakes on a Plane | - | - | - | $579,253 | 3,555 | $34,020,814 | Aug 18 | New Line Cinema | false |
| 17 | Monster House | - | - | - | $322,241 | 3,553 | $73,661,010 | Jul 21 | Sony Pictures Releasing | false |
| 18 | Material Girls | - | - | - | $300,609 | 1,509 | $11,449,638 | Aug 18 | Metro-Goldwyn-Mayer (MGM) | false |
| 19 | Superman Returns | - | - | - | $241,087 | 4,065 | $200,081,192 | Jun 28 | Warner Bros. | false |
| 20 | Cars | - | - | - | $235,705 | 3,988 | $244,082,982 | Jun 9 | Walt Disney Studios Motion Pictures | false |
| 21 | The Devil Wears Prada | - | - | - | $199,622 | 2,882 | $124,740,460 | Jun 30 | Twentieth Century Fox | false |
| 22 | The Ant Bully | - | - | - | $196,920 | 3,050 | $28,142,535 | Jul 28 | Warner Bros. | false |
| 23 | Pulse | - | - | - | $140,186 | 2,323 | $20,264,436 | Aug 11 | - | false |
| 24 | Lassie | - | - | - | $120,459 | 169 | $652,163 | Sep 1 | IDP Distribution | false |
| 25 | Trust the Man | - | - | - | $101,293 | 260 | $1,530,535 | Aug 18 | - | false |
| 26 | Click | - | - | - | $97,114 | 3,764 | $137,355,633 | Jun 23 | Revolution Studios | false |
| 27 | Zoom | - | - | - | $94,312 | 2,501 | $11,989,328 | Aug 11 | Revolution Studios | false |
| 28 | The Descent | - | - | - | $93,097 | 2,095 | $26,024,456 | Aug 4 | Lionsgate Films | false |
| 29 | Miami Vice | - | - | - | $92,685 | 3,026 | $63,450,470 | Jul 28 | Universal Pictures | false |
| 30 | Deep Sea | - | - | - | $90,640 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 31 | You, Me and Dupree | - | - | - | $87,340 | 3,137 | $75,628,110 | Jul 14 | Universal Pictures | false |
| 32 | John Tucker Must Die | - | - | - | $74,722 | 2,566 | $41,011,711 | Jul 28 | Twentieth Century Fox | false |
| 33 | An Inconvenient Truth | - | - | - | $68,943 | 587 | $24,146,161 | May 24 | Paramount Classics | false |
| 34 | Idiocracy | - | - | - | $53,192 | 130 | $444,093 | Sep 1 | Twentieth Century Fox | false |
| 35 | Over the Hedge | - | - | - | $52,506 | 4,093 | $155,019,340 | May 19 | DreamWorks | false |
| 36 | Lady in the Water | - | - | - | $46,170 | 3,235 | $42,285,169 | Jul 21 | Warner Bros. | false |
| 37 | Nacho Libre | - | - | - | $34,863 | 3,083 | $80,197,993 | Jun 16 | Paramount Pictures | false |
| 38 | My Super Ex-Girlfriend | - | - | - | $29,730 | 2,702 | $22,530,295 | Jul 21 | Twentieth Century Fox | false |
| 39 | The Lake House | - | - | - | $17,783 | 2,645 | $52,330,111 | Jun 16 | Warner Bros. | false |
| 40 | A Prairie Home Companion | - | - | - | $15,123 | 767 | $20,342,852 | Jun 9 | Picturehouse | false |
| 41 | The Break-Up | - | - | - | $14,490 | 3,146 | $118,703,275 | Jun 2 | Universal Pictures | false |
| 42 | The Fast and the Furious: Tokyo Drift | - | - | - | $12,960 | 3,030 | $62,514,415 | Jun 16 | Universal Pictures | false |
| 43 | Garfield: A Tail of Two Kitties | - | - | - | $12,205 | 2,981 | $28,426,747 | Jun 16 | Twentieth Century Fox | false |
| 44 | A Scanner Darkly | - | - | - | $10,786 | 263 | $5,501,616 | Jul 7 | Warner Independent Pictures (WIP) | false |
| 45 | X-Men: The Last Stand | - | - | - | $8,113 | 3,714 | $234,362,462 | May 26 | Twentieth Century Fox | false |
| 46 | Leonard Cohen: I'm Your Man | - | - | - | $7,875 | 55 | $1,044,254 | Jun 21 | Lionsgate Films | false |
| 47 | Clerks II | - | - | - | $6,041 | 2,150 | $24,148,068 | Jul 21 | - | false |
| 48 | Mutual Appreciation | - | - | - | $2,886 | 5 | $103,509 | Sep 1 | Goodbye Cruel Releasing | false |
