| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Superman Returns | - | - | - | $76,033,267 | 4,065 | $200,081,192 | Jun 28 | Warner Bros. | false |
| 2 | The Devil Wears Prada | - | - | - | $40,135,062 | 2,882 | $124,740,460 | Jun 30 | Twentieth Century Fox | false |
| 3 | Click | - | - | - | $29,110,313 | 3,764 | $137,355,633 | Jun 23 | Revolution Studios | false |
| 4 | Cars | - | - | - | $22,484,325 | 3,988 | $244,082,982 | Jun 9 | Walt Disney Studios Motion Pictures | false |
| 5 | Nacho Libre | - | - | - | $9,720,352 | 3,083 | $80,197,993 | Jun 16 | Paramount Pictures | false |
| 6 | The Lake House | - | - | - | $7,145,534 | 2,645 | $52,330,111 | Jun 16 | Warner Bros. | false |
| 7 | The Fast and the Furious: Tokyo Drift | - | - | - | $6,301,040 | 3,030 | $62,514,415 | Jun 16 | Universal Pictures | false |
| 8 | Waist Deep | - | - | - | $4,708,766 | 1,006 | $21,344,312 | Jun 23 | Rogue Pictures | false |
| 9 | The Break-Up | - | - | - | $4,481,075 | 3,146 | $118,703,275 | Jun 2 | Universal Pictures | false |
| 10 | The Da Vinci Code | - | - | - | $3,746,611 | 3,757 | $217,536,138 | May 19 | Sony Pictures Releasing | false |
| 11 | X-Men: The Last Stand | - | - | - | $3,322,498 | 3,714 | $234,362,462 | May 26 | Twentieth Century Fox | false |
| 12 | Garfield: A Tail of Two Kitties | - | - | - | $3,273,359 | 2,981 | $28,426,747 | Jun 16 | Twentieth Century Fox | false |
| 13 | An Inconvenient Truth | - | - | - | $2,602,878 | 587 | $24,146,161 | May 24 | Paramount Classics | false |
| 14 | A Prairie Home Companion | - | - | - | $2,183,569 | 767 | $20,342,852 | Jun 9 | Picturehouse | false |
| 15 | Over the Hedge | - | - | - | $2,075,200 | 4,093 | $155,019,340 | May 19 | DreamWorks | false |
| 16 | Poseidon | - | - | - | $1,384,379 | 3,555 | $60,674,817 | May 12 | Warner Bros. | false |
| 17 | RV | - | - | - | $752,118 | 3,651 | $71,726,025 | Apr 28 | Sony Pictures Releasing | false |
| 18 | The Omen | - | - | - | $728,470 | 2,723 | $54,607,383 | Jun 6 | Twentieth Century Fox | false |
| 19 | Mission: Impossible III | - | - | - | $725,604 | 4,059 | $134,029,801 | May 5 | Paramount Pictures | false |
| 20 | Krrish | - | - | - | $559,762 | 59 | $1,430,721 | Jun 30 | Adlabs Films | false |
| 21 | Wordplay | - | - | - | $492,467 | 154 | $3,121,270 | Jun 16 | IFC Films | false |
| 22 | Deep Sea | - | - | - | $477,890 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 23 | Scary Movie 4 | - | - | - | $402,987 | 3,674 | $90,710,620 | Apr 14 | Dimension Films | false |
| 24 | Ice Age 2: The Meltdown | - | - | - | $378,074 | 3,969 | $195,330,621 | Mar 31 | Twentieth Century Fox | false |
| 25 | Keeping Up with the Steins | - | - | - | $197,977 | 163 | $4,339,241 | May 12 | Miramax | false |
| 26 | The Lost City | - | - | - | $144,971 | 56 | $2,484,186 | Apr 28 | Magnolia Pictures | false |
| 27 | Water 2006 Re-release | - | - | - | $136,414 | 91 | $3,278,815 | Apr 28 | Fox Searchlight Pictures | false |
| 28 | Magnificent Desolation: Walking on the Moon | - | - | - | $134,131 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 29 | Stick It | - | - | - | $126,438 | 2,044 | $26,910,736 | Apr 28 | Walt Disney Studios Motion Pictures | false |
| 30 | The Shaggy Dog | - | - | - | $123,316 | 3,501 | $61,123,569 | Mar 10 | Walt Disney Studios Motion Pictures | false |
| 31 | Peaceful Warrior Limited Domestic Release | - | - | - | $120,929 | 42 | $1,066,748 | Jun 2 | Lionsgate | false |
| 32 | Akeelah and the Bee | - | - | - | $110,428 | 2,195 | $18,848,430 | Apr 28 | Lionsgate | false |
| 33 | Thank You for Smoking | - | - | - | $98,170 | 1,020 | $24,793,509 | Mar 17 | Fox Searchlight Pictures | false |
| 34 | Roving Mars | - | - | - | $90,979 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 35 | Leonard Cohen: I'm Your Man | - | - | - | $84,322 | 55 | $1,044,254 | Jun 21 | Lionsgate | false |
| 36 | The Road to Guantanamo | - | - | - | $78,515 | 25 | $326,876 | Jun 23 | IDP Distribution | false |
| 37 | Just My Luck | - | - | - | $72,569 | 2,543 | $17,326,650 | May 12 | Twentieth Century Fox | false |
| 38 | Who Killed the Electric Car? | - | - | - | $69,184 | 74 | $1,678,874 | Jun 28 | Sony Pictures Classics | false |
| 39 | Goal! The Dream Begins | - | - | - | $68,034 | 1,007 | $4,283,255 | May 12 | Walt Disney Studios Motion Pictures | false |
| 40 | The Wild | - | - | - | $67,213 | 2,854 | $37,384,046 | Apr 14 | Walt Disney Studios Motion Pictures | false |
| 41 | Strangers with Candy | - | - | - | $63,496 | 109 | $2,072,645 | Jun 28 | THINKFilm | false |
| 42 | Aliens of the Deep | - | - | - | $53,359 | 27 | $8,968,684 | Jan 28 | Walt Disney Studios Motion Pictures | false |
| 43 | United 93 | - | - | - | $49,170 | 1,871 | $31,483,450 | Apr 28 | Universal Pictures | false |
| 44 | See No Evil | - | - | - | $48,887 | 1,270 | $15,032,800 | May 19 | Lionsgate | false |
| 45 | Mrs Palfrey at the Claremont | - | - | - | $45,358 | 22 | $1,720,953 | Nov 25 | Cineville | false |
| 46 | An American Haunting | - | - | - | $44,525 | 1,703 | $16,298,046 | May 5 | Freestyle Releasing | false |
| 47 | The Sentinel | - | - | - | $43,136 | 2,851 | $36,280,697 | Apr 21 | Twentieth Century Fox | false |
| 48 | District B13 | - | - | - | $41,033 | 151 | $1,200,216 | Jun 2 | Magnolia Pictures | false |
| 49 | Brick | - | - | - | $38,040 | 45 | $2,075,743 | Mar 31 | Focus Features | false |
| 50 | Inside Man | - | - | - | $35,095 | 2,867 | $88,513,495 | Mar 24 | Universal Pictures | false |
| 51 | Friends with Money | - | - | - | $33,777 | 1,010 | $13,368,437 | Apr 7 | Sony Pictures Classics | false |
| 52 | The Heart of the Game | - | - | - | $33,669 | 21 | $445,374 | Jun 9 | Miramax | false |
| 53 | The King | - | - | - | $30,712 | 16 | $282,183 | May 19 | THINKFilm | false |
| 54 | Army of Shadows | - | - | - | $30,555 | 8 | $741,766 | Apr 28 | Rialto Pictures | false |
| 55 | Lady Vengeance | - | - | - | $25,389 | 15 | $211,667 | Apr 28 | Tartan | false |
| 56 | Russian Dolls | - | - | - | $24,114 | 11 | $326,095 | May 10 | IFC Films | false |
| 57 | The Great New Wonderful | - | - | - | $23,888 | 8 | $150,142 | Jun 23 | First Independent Pictures | false |
| 58 | American Masters: Sketches of Frank Gehry | - | - | - | $23,080 | 21 | $439,309 | May 12 | Sony Pictures Classics | false |
| 59 | Lower City | - | - | - | $20,368 | 8 | $130,794 | Jun 16 | Palm Pictures | false |
| 60 | Kinky Boots | - | - | - | $19,035 | 127 | $1,822,428 | Apr 14 | Miramax | false |
| 61 | The Mostly Unfabulous Social Life of Ethan Green | - | - | - | $18,725 | 7 | $153,122 | Jun 16 | Regent Releasing | false |
| 62 | Art School Confidential | - | - | - | $17,089 | 762 | $3,297,137 | May 5 | Sony Pictures Classics | false |
| 63 | Only Human 2006 Re-release | - | - | - | $16,688 | 13 | $284,961 | Jun 16 | Magnolia Pictures | false |
| 64 | Down in the Valley | - | - | - | $15,179 | 28 | $568,932 | May 5 | THINKFilm | false |
| 65 | Clean | - | - | - | $14,572 | 8 | $138,711 | Apr 28 | Palm Pictures | false |
| 66 | The Motel | - | - | - | $9,940 | 4 | $51,540 | Jun 28 | Palm Pictures | false |
| 67 | The Puffy Chair | - | - | - | $9,015 | 7 | $194,523 | Jun 2 | IDP Distribution | false |
| 68 | The Death of Mr. Lazarescu | - | - | - | $8,062 | 5 | $80,301 | Apr 26 | Tartan | false |
| 69 | Lucky Number Slevin | - | - | - | $6,449 | 1,989 | $22,495,466 | Apr 7 | Metro-Goldwyn-Mayer (MGM) | false |
| 70 | Three Times | - | - | - | $6,286 | 5 | $151,922 | Apr 26 | IFC Films | false |
| 71 | Two Drifters | - | - | - | $6,212 | 1 | $24,452 | Jun 23 | Strand Releasing | false |
| 72 | Unidentified | - | - | - | $5,778 | 24 | $224,099 | Apr 28 | Five & Two Pictures | false |
| 73 | Look Both Ways | - | - | - | $5,744 | 11 | $105,067 | Apr 14 | Kino International | false |
| 74 | Phat Girlz | - | - | - | $5,561 | 1,060 | $7,061,128 | Apr 7 | Fox Searchlight Pictures | false |
| 75 | C.S.A.: The Confederate States of America | - | - | - | $5,416 | 28 | $672,156 | Oct 7 | IFC Films | false |
| 76 | Shem | - | - | - | $5,332 | 2 | $14,804 | May 26 | HP Releasing | false |
| 77 | Crossing the Bridge: The Sound of Istanbul | - | - | - | $5,236 | 3 | $70,685 | Jun 9 | Strand Releasing | false |
| 78 | The Child | - | - | - | $5,145 | 40 | $651,941 | Mar 24 | Sony Pictures Classics | false |
| 79 | 12 and Holding | - | - | - | $5,103 | 15 | $96,464 | May 19 | IFC Films | false |
| 80 | Space Station 3D | - | - | - | $4,540 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 81 | The Fallen Idol | - | - | - | $3,886 | 4 | $141,502 | Feb 10 | Rialto Pictures | false |
| 82 | Joyeux Noel | - | - | - | $3,706 | 53 | $1,054,361 | Dec 16 | Sony Pictures Classics | false |
| 83 | Cavite | - | - | - | $3,475 | 3 | $70,071 | May 26 | Truly Indie | false |
| 84 | Don't Come Knocking | - | - | - | $3,458 | 32 | $440,793 | Mar 17 | Sony Pictures Classics | false |
| 85 | The Hidden Blade | - | - | - | $3,443 | 4 | $38,147 | Jun 23 | Tartan | false |
| 86 | Tsotsi | - | - | - | $2,580 | 122 | $2,912,606 | Feb 24 | Miramax | false |
| 87 | The Devil and Daniel Johnston | - | - | - | $2,538 | 17 | $334,450 | Mar 31 | Sony Pictures Classics | false |
| 88 | Neil Young: Heart of Gold | - | - | - | $2,364 | 65 | $1,904,606 | Feb 10 | Paramount Classics | false |
| 89 | Lemming | - | - | - | $1,973 | 4 | $81,698 | May 19 | Strand Releasing | false |
| 90 | Iron Island | - | - | - | $1,386 | 4 | $27,177 | Mar 31 | Kino International | false |
| 91 | Say Uncle | - | - | - | $1,382 | 1 | $5,361 | Jun 23 | TLA Releasing | false |
| 92 | Mongolian Ping Pong | - | - | - | $1,174 | 5 | $71,223 | Apr 21 | First Run | false |
| 93 | The World's Fastest Indian | - | - | - | $1,151 | 251 | $5,128,124 | Dec 7 | Magnolia Pictures | false |
| 94 | Rank | - | - | - | $615 | 1 | $2,485 | Jun 28 | IFC Films | false |
| 95 | Sir! No Sir! | - | - | - | $561 | 7 | $116,944 | Apr 7 | Balcony Releasing | false |
| 96 | Galapagos | - | - | - | $276 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 97 | Typhoon | - | - | - | $128 | 24 | $139,059 | Jun 2 | Paramount Classics | false |
| 98 | Coastlines | - | - | - | $120 | 2 | $7,883 | May 31 | IFC Films | false |
