| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Couples Retreat | - | - | - | $38,292,965 | 3,074 | $109,204,945 | Oct 9 | Universal Pictures | false |
| 2 | Zombieland | - | - | - | $16,735,741 | 3,171 | $75,590,286 | Oct 2 | Sony Pictures Releasing | false |
| 3 | Cloudy with a Chance of Meatballs | - | - | - | $14,103,377 | 3,119 | $124,870,275 | Sep 18 | Sony Pictures Releasing | false |
| 4 | Paranormal Activity | - | - | - | $9,217,720 | 2,712 | $107,918,810 | Sep 25 | Paramount Pictures | false |
| 5 | Toy Story 2009 Re-release | - | - | - | $9,081,120 | 1,752 | $30,702,446 | Oct 2 | Walt Disney Studios Motion Pictures | false |
| 6 | Surrogates | - | - | - | $4,858,538 | 2,992 | $38,577,772 | Sep 25 | Walt Disney Studios Motion Pictures | false |
| 7 | The Invention of Lying | - | - | - | $3,797,317 | 1,743 | $18,451,251 | Oct 2 | Warner Bros. | false |
| 8 | Whip It | - | - | - | $3,219,021 | 1,738 | $13,043,363 | Oct 2 | Fox Searchlight Pictures | false |
| 9 | Capitalism: A Love Story | - | - | - | $3,027,335 | 995 | $14,363,397 | Sep 23 | Overture Films | false |
| 10 | Fame | - | - | - | $2,928,854 | 3,133 | $22,455,510 | Sep 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 11 | The Informant! | - | - | - | $2,518,536 | 2,505 | $33,316,821 | Sep 18 | Warner Bros. | false |
| 12 | I Can Do Bad All by Myself | - | - | - | $1,697,757 | 2,255 | $51,733,921 | Sep 11 | Lionsgate | false |
| 13 | Love Happens | - | - | - | $1,656,430 | 1,922 | $22,965,110 | Sep 18 | Universal Pictures | false |
| 14 | Good Hair | - | - | - | $1,173,714 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
| 15 | Inglourious Basterds | - | - | - | $993,705 | 3,358 | $120,540,719 | Aug 21 | The Weinstein Company | false |
| 16 | 9 | - | - | - | $964,081 | 2,060 | $31,749,894 | Sep 9 | Focus Features | false |
| 17 | Pandorum | - | - | - | $948,189 | 2,506 | $10,330,853 | Sep 25 | Overture Films | false |
| 18 | G.I. Joe: The Rise of Cobra | - | - | - | $779,836 | 4,007 | $150,201,498 | Aug 7 | Paramount Pictures | false |
| 19 | All About Steve | - | - | - | $731,795 | 2,265 | $33,862,903 | Sep 4 | Twentieth Century Fox | false |
| 20 | Bright Star | - | - | - | $718,886 | 380 | $4,444,637 | Sep 16 | Apparition | false |
| 21 | Jennifer's Body | - | - | - | $633,527 | 2,738 | $16,204,793 | Sep 18 | Twentieth Century Fox | false |
| 22 | A Serious Man | - | - | - | $527,978 | 262 | $9,228,768 | Oct 2 | Focus Features | false |
| 23 | The Hangover | - | - | - | $482,231 | 3,545 | $277,322,503 | Jun 5 | Warner Bros. | false |
| 24 | Harry Potter and the Half-Blood Prince | - | - | - | $470,306 | 4,455 | $301,959,197 | Jul 15 | Warner Bros. | false |
| 25 | Julie & Julia | - | - | - | $465,762 | 2,528 | $94,125,426 | Aug 7 | Sony Pictures Releasing | false |
| 26 | From Mexico with Love | - | - | - | $363,361 | 279 | $548,787 | Oct 9 | Roadside Attractions | false |
| 27 | The Final Destination | - | - | - | $312,015 | 3,121 | $66,477,700 | Aug 28 | Warner Bros. | false |
| 28 | District 9 | - | - | - | $290,909 | 3,180 | $115,646,235 | Aug 14 | TriStar Pictures | false |
| 29 | I Hope They Serve Beer in Hell | - | - | - | $218,577 | 266 | $1,429,299 | Sep 25 | Freestyle Releasing | false |
| 30 | Wake Up Sid | - | - | - | $216,279 | 79 | $718,766 | Oct 2 | UTV Motion Pictures | false |
| 31 | The Time Traveler's Wife | - | - | - | $205,631 | 2,988 | $63,414,846 | Aug 14 | Warner Bros. | false |
| 32 | The Boys Are Back | - | - | - | $204,986 | 108 | $809,752 | Sep 25 | Miramax | false |
| 33 | Sorority Row | - | - | - | $194,055 | 2,665 | $11,965,282 | Sep 11 | Summit Entertainment | false |
| 34 | Ice Age: Dawn of the Dinosaurs | - | - | - | $187,933 | 4,102 | $196,573,705 | Jul 1 | Twentieth Century Fox | false |
| 35 | The September Issue | - | - | - | $187,346 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 36 | More Than a Game | - | - | - | $147,835 | 111 | $950,675 | Oct 2 | Lionsgate | false |
| 37 | Halloween II | - | - | - | $130,142 | 3,088 | $33,392,973 | Aug 28 | Dimension Films | false |
| 38 | Under the Sea 3D | - | - | - | $128,294 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 39 | Aliens in the Attic | - | - | - | $117,215 | 3,108 | $25,200,412 | Jul 31 | Twentieth Century Fox | false |
| 40 | 500 Days of Summer | - | - | - | $102,487 | 1,048 | $32,391,374 | Jul 17 | Fox Searchlight Pictures | false |
| 41 | Transformers: Revenge of the Fallen | - | - | - | $90,761 | 4,293 | $402,111,870 | Jun 24 | DreamWorks | false |
| 42 | My One and Only | - | - | - | $81,039 | 256 | $2,479,538 | Aug 21 | Freestyle Releasing | false |
| 43 | Do Knot Disturb | - | - | - | $58,711 | 57 | $213,525 | Oct 2 | Adlabs Films | false |
| 44 | Whiteout | - | - | - | $48,929 | 2,745 | $10,275,638 | Sep 11 | Warner Bros. | false |
| 45 | Shorts | - | - | - | $34,814 | 3,105 | $20,919,166 | Aug 21 | Warner Bros. | false |
| 46 | Night at the Museum: Battle of the Smithsonian | - | - | - | $27,472 | 4,101 | $177,243,721 | May 22 | Twentieth Century Fox | false |
| 47 | The Hurt Locker | - | - | - | $23,718 | 535 | $17,017,811 | Jun 26 | Summit Entertainment | false |
| 48 | Adam | - | - | - | $17,283 | 177 | $2,277,396 | Jul 29 | Fox Searchlight Pictures | false |
| 49 | Extract | - | - | - | $16,967 | 1,614 | $10,823,158 | Sep 4 | Miramax | false |
| 50 | What's Your Raashee? | - | - | - | $11,206 | 78 | $257,868 | Sep 25 | UTV Motion Pictures | false |
| 51 | The Other Man | - | - | - | $7,583 | 11 | $149,528 | Sep 11 | Image Entertainment | false |
| 52 | The Cove | - | - | - | $7,478 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
| 53 | Chelsea on the Rocks | - | - | - | $3,224 | 1 | $11,799 | Oct 2 | Aliquot Films | false |
| 54 | Paper Heart | - | - | - | $2,483 | 96 | $1,274,062 | Aug 7 | Overture Films | false |
| 55 | American Casino | - | - | - | $920 | 3 | $50,437 | Aug 14 | Argot Pictures | false |
| 56 | Goodbye Solo | - | - | - | $892 | 34 | $870,781 | Mar 27 | Roadside Attractions | false |
| 57 | The Stoning of Soraya M. | - | - | - | $332 | 34 | $637,421 | Jun 26 | Roadside Attractions | false |
