| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Departed | - | - | - | $30,757,790 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 2 | The Texas Chainsaw Massacre: The Beginning | - | - | - | $20,084,000 | 2,820 | $39,517,763 | Oct 6 | New Line Cinema | true |
| 3 | Open Season | - | - | - | $17,900,758 | 3,833 | $85,105,259 | Sep 29 | Sony Pictures Releasing | false |
| 4 | Employee of the Month | - | - | - | $12,586,279 | 2,579 | $28,444,855 | Oct 6 | Lionsgate | false |
| 5 | The Guardian | - | - | - | $10,624,174 | 3,241 | $55,011,732 | Sep 29 | Walt Disney Studios Motion Pictures | false |
| 6 | Jackass Number Two | - | - | - | $7,346,428 | 3,063 | $72,778,712 | Sep 22 | Paramount Pictures | false |
| 7 | School for Scoundrels | - | - | - | $3,850,708 | 3,007 | $17,807,569 | Sep 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 8 | Gridiron Gang | - | - | - | $2,499,920 | 3,510 | $38,432,823 | Sep 15 | Sony Pictures Releasing | false |
| 9 | The Illusionist | - | - | - | $2,142,944 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 10 | Trailer Park Boys: The Movie | - | - | - | $1,467,000 | 203 | $3,860,678 | Oct 6 | Alliance Atlantis Vivafilm | true |
| 11 | Little Miss Sunshine | - | - | - | $1,439,385 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 12 | Flyboys | - | - | - | $1,182,146 | 2,033 | $13,090,630 | Sep 22 | Metro-Goldwyn-Mayer (MGM) | false |
| 13 | Facing the Giants | - | - | - | $1,147,000 | 441 | $10,178,331 | Sep 29 | IDP Distribution | true |
| 14 | The Science of Sleep | - | - | - | $767,934 | 243 | $4,670,644 | Sep 22 | Warner Independent Pictures (WIP) | false |
| 15 | The Black Dahlia | - | - | - | $632,165 | 2,236 | $22,545,080 | Sep 15 | Universal Pictures | false |
| 16 | The Queen | - | - | - | $475,000 | 1,850 | $56,441,711 | Sep 30 | Miramax | true |
| 17 | The Covenant | - | - | - | $463,419 | 2,681 | $23,380,495 | Sep 8 | Screen Gems | false |
| 18 | Invincible | - | - | - | $441,000 | 2,987 | $57,806,952 | Aug 25 | Walt Disney Studios Motion Pictures | true |
| 19 | The Last Kiss | - | - | - | $419,890 | 1,359 | $11,614,790 | Sep 15 | DreamWorks | false |
| 20 | Barnyard | - | - | - | $411,347 | 3,311 | $72,637,803 | Aug 4 | Paramount Pictures | false |
| 21 | Monster House | - | - | - | $395,758 | 3,553 | $73,661,010 | Jul 21 | Sony Pictures Releasing | false |
| 22 | Talladega Nights: The Ballad of Ricky Bobby | - | - | - | $347,964 | 3,807 | $148,213,377 | Aug 4 | Sony Pictures Releasing | false |
| 23 | The Last King of Scotland | - | - | - | $338,647 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 24 | Superman Returns | - | - | - | $331,938 | 4,065 | $200,081,192 | Jun 28 | Warner Bros. | false |
| 25 | Everyone's Hero | - | - | - | $326,984 | 2,898 | $14,523,101 | Sep 15 | Twentieth Century Fox | false |
| 26 | Fearless | - | - | - | $305,859 | 1,810 | $24,633,730 | Sep 22 | Rogue Pictures | false |
| 27 | All the King's Men | - | - | - | $285,993 | 1,520 | $7,221,458 | Sep 22 | Sony Pictures Releasing | false |
| 28 | Deep Sea | - | - | - | $186,700 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 29 | The Devil Wears Prada | - | - | - | $181,974 | 2,882 | $124,740,460 | Jun 30 | Twentieth Century Fox | false |
| 30 | Accepted | - | - | - | $160,650 | 2,917 | $36,323,505 | Aug 18 | Universal Pictures | false |
| 31 | The U.S. vs. John Lennon | - | - | - | $148,625 | 65 | $1,109,146 | Sep 15 | Lionsgate | false |
| 32 | The Wicker Man | - | - | - | $136,114 | 2,784 | $23,649,127 | Sep 1 | Warner Bros. | false |
| 33 | Crank | - | - | - | $135,586 | 2,515 | $27,838,408 | Sep 1 | Lionsgate | false |
| 34 | The Protector | - | - | - | $81,603 | 1,541 | $12,044,087 | Sep 8 | Dragon Dynasty | false |
| 35 | World Trade Center | - | - | - | $72,658 | 3,021 | $70,278,893 | Aug 9 | Paramount Pictures | false |
| 36 | The Descent | - | - | - | $48,765 | 2,095 | $26,024,456 | Aug 4 | Lionsgate | false |
| 37 | An Inconvenient Truth | - | - | - | $40,158 | 587 | $24,146,161 | May 24 | Paramount Classics | false |
| 38 | The Ant Bully | - | - | - | $26,570 | 3,050 | $28,142,535 | Jul 28 | Warner Bros. | false |
| 39 | Beerfest | - | - | - | $20,050 | 2,964 | $19,185,184 | Aug 25 | Warner Bros. | false |
| 40 | Pulse | - | - | - | $16,988 | 2,323 | $20,264,436 | Aug 11 | Dimension Films | false |
| 41 | Love's Abiding Joy | - | - | - | $14,683 | 207 | $252,726 | Oct 6 | The Bigger Picture | false |
| 42 | Material Girls | - | - | - | $12,892 | 1,509 | $11,449,638 | Aug 18 | Metro-Goldwyn-Mayer (MGM) | false |
| 43 | A Prairie Home Companion | - | - | - | $7,265 | 767 | $20,342,852 | Jun 9 | Picturehouse | false |
| 44 | Kettle of Fish | - | - | - | $6,016 | 3 | $7,196 | Oct 6 | Aloha Releasing Inc. | false |
| 45 | A Scanner Darkly | - | - | - | $3,338 | 263 | $5,501,616 | Jul 7 | Warner Independent Pictures (WIP) | false |
