| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Wallace & Gromit: The Curse of the Were-Rabbit | - | - | - | $18,741,841 | 3,656 | $56,110,897 | Oct 5 | DreamWorks Distribution | false |
| 2 | Flightplan | - | - | - | $12,087,368 | 3,424 | $89,707,299 | Sep 23 | Walt Disney Studios Motion Pictures | false |
| 3 | In Her Shoes | - | - | - | $11,298,090 | 2,840 | $32,880,591 | Oct 7 | Twentieth Century Fox | false |
| 4 | Two for the Money | - | - | - | $9,815,055 | 2,397 | $22,991,379 | Oct 7 | Universal Pictures | false |
| 5 | The Gospel | - | - | - | $8,191,979 | 983 | $15,778,152 | Oct 7 | Screen Gems | false |
| 6 | Corpse Bride | - | - | - | $7,433,675 | 3,204 | $53,359,111 | Sep 16 | Warner Bros. | false |
| 7 | Waiting... | - | - | - | $6,872,387 | 1,652 | $16,124,543 | Oct 7 | Lionsgate | false |
| 8 | Serenity | - | - | - | $6,052,570 | 2,189 | $25,514,517 | Sep 30 | Universal Pictures | false |
| 9 | A History of Violence | - | - | - | $5,826,000 | 1,348 | $31,504,633 | Sep 23 | New Line Cinema | true |
| 10 | Into the Blue | - | - | - | $5,406,272 | 2,789 | $18,801,234 | Sep 30 | Sony Pictures Releasing | false |
| 11 | The Greatest Game Ever Played | - | - | - | $4,542,730 | 1,810 | $15,337,393 | Sep 30 | Walt Disney Studios Motion Pictures | false |
| 12 | Just Like Heaven | - | - | - | $3,882,021 | 3,543 | $48,318,130 | Sep 16 | DreamWorks Distribution | false |
| 13 | The Exorcism of Emily Rose | - | - | - | $2,696,326 | 3,045 | $75,072,454 | Sep 9 | Screen Gems | false |
| 14 | The 40-Year-Old Virgin | - | - | - | $2,088,545 | 3,006 | $109,449,237 | Aug 19 | Universal Pictures | false |
| 15 | Roll Bounce | - | - | - | $1,952,839 | 1,661 | $17,380,866 | Sep 23 | Fox Searchlight Pictures | false |
| 16 | Proof | - | - | - | $1,482,447 | 517 | $7,535,331 | Sep 16 | Miramax | true |
| 17 | Lord of War | - | - | - | $791,743 | 2,814 | $24,149,632 | Sep 16 | Lionsgate | false |
| 18 | March of the Penguins | - | - | - | $558,199 | 2,506 | $77,437,223 | Jun 24 | Warner Independent Pictures (WIP) | false |
| 19 | Oliver Twist | - | - | - | $501,012 | 779 | $2,080,321 | Sep 23 | Sony Pictures Releasing | false |
| 20 | Good Night, and Good Luck. | - | - | - | $488,950 | 929 | $31,558,003 | Oct 7 | Warner Independent Pictures (WIP) | false |
| 21 | Charlie and the Chocolate Factory | - | - | - | $416,320 | 3,790 | $206,459,076 | Jul 15 | Warner Bros. | false |
| 22 | Transporter 2 | - | - | - | $347,726 | 3,320 | $43,095,856 | Sep 2 | Twentieth Century Fox | false |
| 23 | War of the Worlds | - | - | - | $250,671 | 3,910 | $234,280,354 | Jun 29 | Paramount Pictures | false |
| 24 | Everything Is Illuminated | - | - | - | $250,489 | 110 | $1,712,337 | Sep 16 | Warner Independent Pictures (WIP) | false |
| 25 | Four Brothers | - | - | - | $168,744 | 2,649 | $74,494,381 | Aug 12 | Paramount Pictures | false |
| 26 | Madagascar | - | - | - | $166,539 | 4,142 | $193,595,521 | May 27 | DreamWorks Distribution | false |
| 27 | Separate Lies | - | - | - | $158,006 | 127 | $924,260 | Sep 16 | Fox Searchlight Pictures | false |
| 28 | Fantastic Four | - | - | - | $145,135 | 3,619 | $154,696,080 | Jul 8 | Twentieth Century Fox | false |
| 29 | Red Eye | - | - | - | $125,728 | 3,134 | $57,891,803 | Aug 19 | DreamWorks Distribution | false |
| 30 | The Prize Winner of Defiance, Ohio | - | - | - | $120,058 | 41 | $627,844 | Sep 30 | DreamWorks Distribution | false |
| 31 | The Constant Gardener | - | - | - | $118,880 | 1,387 | $33,579,797 | Aug 31 | Focus Features | false |
| 32 | The Dukes of Hazzard | - | - | - | $116,752 | 3,785 | $80,270,227 | Aug 5 | Warner Bros. | false |
| 33 | Mr. & Mrs. Smith | - | - | - | $114,505 | 3,451 | $186,336,279 | Jun 10 | Twentieth Century Fox | false |
| 34 | The Skeleton Key | - | - | - | $103,485 | 2,784 | $47,907,715 | Aug 12 | Universal Pictures | false |
| 35 | An Unfinished Life | - | - | - | $93,000 | 888 | $8,586,392 | Sep 9 | Miramax | false |
| 36 | Grizzly Man | - | - | - | $91,879 | 105 | $3,178,403 | Aug 12 | Lionsgate | false |
| 37 | Batman Begins | - | - | - | $78,541 | 3,858 | $205,343,774 | Jun 15 | Warner Bros. | false |
| 38 | Capote | - | - | - | $55,372 | 1,239 | $28,750,530 | Sep 30 | Sony Pictures Classics | false |
| 39 | Duma | - | - | - | $51,871 | 42 | $870,067 | Apr 22 | Warner Bros. | false |
| 40 | Little Manhattan | - | - | - | $37,550 | 35 | $385,373 | Sep 30 | Twentieth Century Fox | false |
| 41 | Star Wars: Episode III - Revenge of the Sith | - | - | - | $25,956 | 3,663 | $380,270,577 | May 19 | Twentieth Century Fox | false |
| 42 | Must Love Dogs | - | - | - | $15,427 | 2,505 | $43,894,863 | Jul 29 | Warner Bros. | false |
| 43 | Mad Hot Ballroom | - | - | - | $10,311 | 202 | $8,117,961 | May 13 | Paramount Classics | false |
| 44 | Hustle & Flow | - | - | - | $3,736 | 1,016 | $22,202,809 | Jul 22 | Paramount Classics | false |
| 45 | Après Vous | - | - | - | $872 | 42 | $830,292 | Jun 3 | Paramount Classics | false |
| 46 | Cinderella Man | - | - | - | $740 | 2,820 | $61,649,911 | Jun 3 | Universal Pictures | false |
| 47 | Asylum | - | - | - | $504 | 55 | $375,403 | Aug 12 | Paramount Classics | false |
