| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Couples Retreat | - | - | - | $4,006,225 | 3,074 | $109,204,945 | Oct 9 | Universal Pictures | false |
| 2 | Cloudy with a Chance of Meatballs | - | - | - | $2,575,897 | 3,119 | $124,870,275 | Sep 18 | Sony Pictures Releasing | false |
| 3 | Zombieland | - | - | - | $1,933,310 | 3,171 | $75,590,286 | Oct 2 | Sony Pictures Releasing | false |
| 4 | Paranormal Activity | - | - | - | $1,317,025 | 2,712 | $107,918,810 | Sep 25 | Paramount Pictures | false |
| 5 | Toy Story 2009 Re-release | - | - | - | $1,314,477 | 1,752 | $30,702,446 | Oct 2 | Walt Disney Studios Motion Pictures | false |
| 6 | Surrogates | - | - | - | $590,224 | 2,992 | $38,577,772 | Sep 25 | Walt Disney Studios Motion Pictures | false |
| 7 | The Invention of Lying | - | - | - | $458,054 | 1,743 | $18,451,251 | Oct 2 | Warner Bros. | false |
| 8 | Capitalism: A Love Story | - | - | - | $397,043 | 995 | $14,363,397 | Sep 23 | Overture Films | false |
| 9 | Whip It | - | - | - | $391,509 | 1,738 | $13,043,363 | Oct 2 | Fox Searchlight Pictures | false |
| 10 | Fame | - | - | - | $385,787 | 3,133 | $22,455,510 | Sep 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 11 | The Informant! | - | - | - | $314,250 | 2,505 | $33,316,821 | Sep 18 | Warner Bros. | false |
| 12 | Love Happens | - | - | - | $189,400 | 1,922 | $22,965,110 | Sep 18 | Universal Pictures | false |
| 13 | I Can Do Bad All by Myself | - | - | - | $185,853 | 2,255 | $51,733,921 | Sep 11 | Lionsgate | false |
| 14 | Inglourious Basterds | - | - | - | $144,735 | 3,358 | $120,540,719 | Aug 21 | The Weinstein Company | false |
| 15 | Good Hair | - | - | - | $134,494 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
| 16 | 9 | - | - | - | $134,431 | 2,060 | $31,749,894 | Sep 9 | Focus Features | false |
| 17 | Pandorum | - | - | - | $125,774 | 2,506 | $10,330,853 | Sep 25 | Overture Films | false |
| 18 | Bright Star | - | - | - | $94,052 | 380 | $4,444,637 | Sep 16 | Apparition | false |
| 19 | G.I. Joe: The Rise of Cobra | - | - | - | $91,971 | 4,007 | $150,201,498 | Aug 7 | Paramount Pictures | false |
| 20 | All About Steve | - | - | - | $72,323 | 2,265 | $33,862,903 | Sep 4 | Twentieth Century Fox | false |
| 21 | A Serious Man | - | - | - | $68,660 | 262 | $9,228,768 | Oct 2 | Focus Features | false |
| 22 | Jennifer's Body | - | - | - | $64,836 | 2,738 | $16,204,793 | Sep 18 | Twentieth Century Fox | false |
| 23 | Harry Potter and the Half-Blood Prince | - | - | - | $61,869 | 4,455 | $301,959,197 | Jul 15 | Warner Bros. | false |
| 24 | The Hangover | - | - | - | $54,893 | 3,545 | $277,322,503 | Jun 5 | Warner Bros. | false |
| 25 | I Hope They Serve Beer in Hell | - | - | - | $34,752 | 266 | $1,429,299 | Sep 25 | Freestyle Releasing | false |
| 26 | Under the Sea 3D | - | - | - | $33,562 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 27 | The Final Destination | - | - | - | $33,558 | 3,121 | $66,477,700 | Aug 28 | Warner Bros. | false |
| 28 | From Mexico with Love | - | - | - | $29,021 | 279 | $548,787 | Oct 9 | Roadside Attractions | false |
| 29 | Ice Age: Dawn of the Dinosaurs | - | - | - | $26,424 | 4,102 | $196,573,705 | Jul 1 | Twentieth Century Fox | false |
| 30 | The September Issue | - | - | - | $24,124 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 31 | The Boys Are Back | - | - | - | $23,606 | 108 | $809,752 | Sep 25 | Miramax | false |
| 32 | The Time Traveler's Wife | - | - | - | $22,195 | 2,988 | $63,414,846 | Aug 14 | Warner Bros. | false |
| 33 | More Than a Game | - | - | - | $20,483 | 111 | $950,675 | Oct 2 | Lionsgate | false |
| 34 | Wake Up Sid | - | - | - | $19,927 | 79 | $718,766 | Oct 2 | UTV Motion Pictures | false |
| 35 | Sorority Row | - | - | - | $18,757 | 2,665 | $11,965,282 | Sep 11 | Summit Entertainment | false |
| 36 | Aliens in the Attic | - | - | - | $15,261 | 3,108 | $25,200,412 | Jul 31 | Twentieth Century Fox | false |
| 37 | 500 Days of Summer | - | - | - | $13,376 | 1,048 | $32,391,374 | Jul 17 | Fox Searchlight Pictures | false |
| 38 | Halloween II | - | - | - | $11,983 | 3,088 | $33,392,973 | Aug 28 | Dimension Films | false |
| 39 | Transformers: Revenge of the Fallen | - | - | - | $11,689 | 4,293 | $402,111,870 | Jun 24 | DreamWorks | false |
| 40 | My One and Only | - | - | - | $10,621 | 256 | $2,479,538 | Aug 21 | Freestyle Releasing | false |
| 41 | Shorts | - | - | - | $3,764 | 3,105 | $20,919,166 | Aug 21 | Warner Bros. | false |
| 42 | Whiteout | - | - | - | $3,637 | 2,745 | $10,275,638 | Sep 11 | Warner Bros. | false |
| 43 | The Hurt Locker | - | - | - | $3,167 | 535 | $17,017,811 | Jun 26 | Summit Entertainment | false |
| 44 | Night at the Museum: Battle of the Smithsonian | - | - | - | $3,055 | 4,101 | $177,243,721 | May 22 | Twentieth Century Fox | false |
| 45 | Adam | - | - | - | $2,526 | 177 | $2,277,396 | Jul 29 | Fox Searchlight Pictures | false |
| 46 | Extract | - | - | - | $2,163 | 1,614 | $10,823,158 | Sep 4 | Miramax | false |
| 47 | What's Your Raashee? | - | - | - | $1,696 | 78 | $257,868 | Sep 25 | UTV Motion Pictures | false |
| 48 | The Cove | - | - | - | $983 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
| 49 | The Other Man | - | - | - | $800 | 11 | $149,528 | Sep 11 | Image Entertainment | false |
| 50 | Chelsea on the Rocks | - | - | - | $637 | 1 | $11,799 | Oct 2 | Aliquot Films | false |
| 51 | Paper Heart | - | - | - | $184 | 96 | $1,274,062 | Aug 7 | Overture Films | false |
| 52 | The Stoning of Soraya M. | - | - | - | $77 | 34 | $637,421 | Jun 26 | Roadside Attractions | false |
| 53 | American Casino | - | - | - | $55 | 3 | $50,437 | Aug 14 | Argot Pictures | false |
