| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Beverly Hills Chihuahua | - | - | - | $2,823,779 | 3,239 | $94,514,402 | Oct 3 | Walt Disney Studios Motion Pictures | false |
| 2 | Body of Lies | - | - | - | $1,634,369 | 2,714 | $39,394,666 | Oct 10 | Warner Bros. | false |
| 3 | Quarantine | - | - | - | $1,481,576 | 2,463 | $31,691,811 | Oct 10 | Screen Gems | false |
| 4 | Eagle Eye | - | - | - | $1,397,491 | 3,614 | $101,440,743 | Sep 26 | DreamWorks | false |
| 5 | Nick and Norah's Infinite Playlist | - | - | - | $764,564 | 2,421 | $31,487,293 | Oct 3 | Sony Pictures Releasing | false |
| 6 | The Express | - | - | - | $575,640 | 2,810 | $9,793,406 | Oct 10 | Universal Pictures | false |
| 7 | Nights in Rodanthe | - | - | - | $572,201 | 2,704 | $41,850,659 | Sep 26 | Warner Bros. | false |
| 8 | City of Ember | - | - | - | $471,941 | 2,023 | $7,873,007 | Oct 10 | Twentieth Century Fox | false |
| 9 | Appaloosa | - | - | - | $454,432 | 1,290 | $20,211,394 | Sep 19 | Warner Bros. | false |
| 10 | The Duchess | - | - | - | $452,561 | 1,207 | $13,848,978 | Sep 19 | Paramount Vantage | false |
| 11 | Fireproof | - | - | - | $366,855 | 905 | $33,456,317 | Sep 26 | The Samuel Goldwyn Company | false |
| 12 | Religulous | - | - | - | $316,711 | 568 | $13,011,160 | Oct 1 | Lionsgate | false |
| 13 | Lakeview Terrace | - | - | - | $316,452 | 2,574 | $39,263,506 | Sep 19 | Screen Gems | false |
| 14 | Burn After Reading | - | - | - | $298,595 | 2,657 | $60,355,347 | Sep 12 | Focus Features | false |
| 15 | An American Carol | - | - | - | $145,000 | 1,639 | $7,013,191 | Oct 3 | Vivendi Entertainment | true |
| 16 | The Family That Preys | - | - | - | $116,219 | 2,070 | $37,105,289 | Sep 12 | Lionsgate | false |
| 17 | Flash of Genius | - | - | - | $115,005 | 1,098 | $4,442,377 | Oct 3 | Universal Pictures | false |
| 18 | Igor | - | - | - | $112,177 | 2,341 | $19,528,602 | Sep 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 19 | The Dark Knight | - | - | - | $92,199 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 20 | Miracle at St. Anna | - | - | - | $83,859 | 1,185 | $7,919,117 | Sep 26 | Walt Disney Studios Motion Pictures | false |
| 21 | My Best Friend's Girl | - | - | - | $81,971 | 2,636 | $19,219,250 | Sep 19 | Lionsgate | false |
| 22 | Righteous Kill | - | - | - | $78,227 | 3,152 | $40,081,410 | Sep 12 | Overture Films | false |
| 23 | How to Lose Friends & Alienate People | - | - | - | $77,393 | 1,750 | $2,778,752 | Oct 3 | Metro-Goldwyn-Mayer (MGM) | false |
| 24 | Blindness | - | - | - | $76,021 | 1,690 | $3,351,751 | Oct 3 | Miramax | false |
| 25 | Ghost Town | - | - | - | $66,057 | 1,512 | $13,367,624 | Sep 19 | DreamWorks | false |
| 26 | Vicky Cristina Barcelona | - | - | - | $46,812 | 726 | $23,216,709 | Aug 15 | Metro-Goldwyn-Mayer (MGM) | false |
| 27 | Journey to the Center of the Earth | - | - | - | $45,303 | 2,830 | $101,704,370 | Jul 11 | Warner Bros. | false |
| 28 | Mamma Mia! | - | - | - | $36,270 | 3,194 | $144,290,968 | Jul 18 | Universal Pictures | false |
| 29 | The Women | - | - | - | $30,266 | 2,995 | $26,902,075 | Sep 12 | Picturehouse | false |
| 30 | RocknRolla | - | - | - | $23,698 | 826 | $5,700,626 | Oct 8 | Warner Bros. | false |
| 31 | Choke | - | - | - | $20,996 | 435 | $2,926,565 | Sep 26 | Fox Searchlight Pictures | false |
| 32 | Tropic Thunder | - | - | - | $16,796 | 3,473 | $110,515,313 | Aug 13 | DreamWorks | false |
| 33 | Fly Me to the Moon 3D | - | - | - | $16,243 | 713 | $13,816,982 | Aug 15 | Summit Entertainment | false |
| 34 | Deep Sea | - | - | - | $16,207 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 35 | Happy-Go-Lucky | - | - | - | $12,706 | 202 | $3,512,016 | Oct 10 | Miramax | false |
| 36 | Death Race | - | - | - | $11,360 | 2,586 | $36,316,032 | Aug 22 | Universal Pictures | false |
| 37 | Get Smart | - | - | - | $10,357 | 3,915 | $130,319,208 | Jun 20 | Warner Bros. | false |
| 38 | Space Chimps | - | - | - | $8,473 | 2,538 | $30,105,968 | Jul 18 | Twentieth Century Fox | false |
| 39 | Babylon A.D. | - | - | - | $7,822 | 3,425 | $22,532,572 | Aug 29 | Twentieth Century Fox | false |
| 40 | Call + Response | - | - | - | $6,954 | 17 | $215,185 | Oct 10 | Fair Trade Pictures | false |
| 41 | Mirrors | - | - | - | $6,870 | 2,664 | $30,691,439 | Aug 15 | Twentieth Century Fox | false |
| 42 | Star Wars: The Clone Wars | - | - | - | $6,033 | 3,452 | $35,161,554 | Aug 15 | Warner Bros. | false |
| 43 | Traitor | - | - | - | $4,526 | 2,108 | $23,530,831 | Aug 27 | Overture Films | false |
| 44 | Disaster Movie | - | - | - | $4,342 | 2,642 | $14,190,901 | Aug 29 | Lionsgate | false |
| 45 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $4,130 | 4,264 | $317,101,119 | May 22 | Paramount Pictures | false |
| 46 | Bangkok Dangerous | - | - | - | $2,867 | 2,654 | $15,298,133 | Sep 5 | Lionsgate | false |
| 47 | Lola Montès | - | - | - | $2,540 | 4 | $120,306 | Oct 10 | Rialto Pictures | false |
| 48 | The Sisterhood of the Traveling Pants 2 | - | - | - | $2,141 | 2,714 | $44,089,964 | Aug 6 | Warner Bros. | false |
| 49 | The Longshots | - | - | - | $1,034 | 2,089 | $11,537,046 | Aug 22 | Metro-Goldwyn-Mayer (MGM) | false |
| 50 | Towelhead | - | - | - | $904 | 100 | $372,124 | Sep 12 | Warner Independent Pictures (WIP) | false |
| 51 | Beer for My Horses | - | - | - | $763 | 91 | $666,045 | Aug 8 | Roadside Attractions | false |
| 52 | Henry Poole Is Here | - | - | - | $714 | 527 | $1,836,515 | Aug 15 | Overture Films | false |
| 53 | Hounddog | - | - | - | $267 | 11 | $131,961 | Sep 19 | Empire Pictures Inc. | false |
| 54 | Everybody Wants to Be Italian | - | - | - | $118 | 98 | $351,416 | Sep 5 | Roadside Attractions | false |
| 55 | The Fall | - | - | - | $99 | 111 | $2,266,905 | May 9 | Roadside Attractions | false |
| 56 | I.O.U.S.A. | - | - | - | $85 | 358 | $821,046 | Aug 22 | Roadside Attractions | false |
| 57 | College | - | - | - | $38 | 2,124 | $4,694,636 | Aug 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 58 | Lower Learning | - | - | - | $31 | 1 | $2,804 | Oct 10 | Anchor Bay Films | false |
