| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Departed | - | - | - | $3,870,323 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 2 | Open Season | - | - | - | $2,275,434 | 3,833 | $85,105,259 | Sep 29 | Sony Pictures Releasing | false |
| 3 | The Texas Chainsaw Massacre: The Beginning | - | - | - | $1,576,000 | 2,820 | $39,517,763 | Oct 6 | New Line Cinema | true |
| 4 | Employee of the Month | - | - | - | $1,178,528 | 2,579 | $28,444,855 | Oct 6 | Lionsgate | false |
| 5 | The Guardian | - | - | - | $1,056,082 | 3,241 | $55,011,732 | Sep 29 | Walt Disney Studios Motion Pictures | false |
| 6 | Jackass Number Two | - | - | - | $829,460 | 3,063 | $72,778,712 | Sep 22 | Paramount Pictures | false |
| 7 | School for Scoundrels | - | - | - | $417,121 | 3,007 | $17,807,569 | Sep 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 8 | Fearless | - | - | - | $305,859 | 1,810 | $24,633,730 | Sep 22 | Rogue Pictures | false |
| 9 | Trailer Park Boys: The Movie | - | - | - | $267,000 | 203 | $3,860,678 | Oct 6 | Alliance Atlantis Vivafilm | true |
| 10 | Gridiron Gang | - | - | - | $263,136 | 3,510 | $38,432,823 | Sep 15 | Sony Pictures Releasing | false |
| 11 | The Illusionist | - | - | - | $236,434 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 12 | Little Miss Sunshine | - | - | - | $160,481 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 13 | Flyboys | - | - | - | $143,073 | 2,033 | $13,090,630 | Sep 22 | Metro-Goldwyn-Mayer (MGM) | false |
| 14 | Facing the Giants | - | - | - | $141,000 | 441 | $10,178,331 | Sep 29 | IDP Distribution | true |
| 15 | The Science of Sleep | - | - | - | $87,514 | 243 | $4,670,644 | Sep 22 | Warner Independent Pictures (WIP) | false |
| 16 | The Black Dahlia | - | - | - | $79,050 | 2,236 | $22,545,080 | Sep 15 | Universal Pictures | false |
| 17 | The Queen | - | - | - | $73,000 | 1,850 | $56,441,711 | Sep 30 | Miramax | true |
| 18 | Everyone's Hero | - | - | - | $70,315 | 2,898 | $14,523,101 | Sep 15 | Twentieth Century Fox | false |
| 19 | The Last Kiss | - | - | - | $55,838 | 1,359 | $11,614,790 | Sep 15 | DreamWorks | false |
| 20 | Barnyard | - | - | - | $53,367 | 3,311 | $72,637,803 | Aug 4 | Paramount Pictures | false |
| 21 | Invincible | - | - | - | $48,000 | 2,987 | $57,806,952 | Aug 25 | Walt Disney Studios Motion Pictures | true |
| 22 | The Covenant | - | - | - | $45,983 | 2,681 | $23,380,495 | Sep 8 | Screen Gems | false |
| 23 | The Last King of Scotland | - | - | - | $45,917 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 24 | Deep Sea | - | - | - | $36,626 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 25 | Superman Returns | - | - | - | $35,436 | 4,065 | $200,081,192 | Jun 28 | Warner Bros. | false |
| 26 | The Devil Wears Prada | - | - | - | $24,581 | 2,882 | $124,740,460 | Jun 30 | Twentieth Century Fox | false |
| 27 | The U.S. vs. John Lennon | - | - | - | $19,475 | 65 | $1,109,146 | Sep 15 | Lionsgate | false |
| 28 | Crank | - | - | - | $16,987 | 2,515 | $27,838,408 | Sep 1 | Lionsgate | false |
| 29 | Accepted | - | - | - | $15,175 | 2,917 | $36,323,505 | Aug 18 | Universal Pictures | false |
| 30 | Love's Abiding Joy | - | - | - | $14,683 | 207 | $252,726 | Oct 6 | The Bigger Picture | false |
| 31 | The Wicker Man | - | - | - | $11,858 | 2,784 | $23,649,127 | Sep 1 | Warner Bros. | false |
| 32 | The Protector | - | - | - | $9,956 | 1,541 | $12,044,087 | Sep 8 | Dragon Dynasty | false |
| 33 | World Trade Center | - | - | - | $8,132 | 3,021 | $70,278,893 | Aug 9 | Paramount Pictures | false |
| 34 | The Descent | - | - | - | $6,203 | 2,095 | $26,024,456 | Aug 4 | Lionsgate | false |
| 35 | An Inconvenient Truth | - | - | - | $6,025 | 587 | $24,146,161 | May 24 | Paramount Classics | false |
| 36 | The Ant Bully | - | - | - | $5,391 | 3,050 | $28,142,535 | Jul 28 | Warner Bros. | false |
| 37 | Beerfest | - | - | - | $2,543 | 2,964 | $19,185,184 | Aug 25 | Warner Bros. | false |
| 38 | Material Girls | - | - | - | $2,101 | 1,509 | $11,449,638 | Aug 18 | Metro-Goldwyn-Mayer (MGM) | false |
| 39 | Pulse | - | - | - | $1,831 | 2,323 | $20,264,436 | Aug 11 | Dimension Films | false |
| 40 | A Scanner Darkly | - | - | - | $1,054 | 263 | $5,501,616 | Jul 7 | Warner Independent Pictures (WIP) | false |
| 41 | A Prairie Home Companion | - | - | - | $610 | 767 | $20,342,852 | Jun 9 | Picturehouse | false |
| 42 | Kettle of Fish | - | - | - | $422 | 3 | $7,196 | Oct 6 | Aloha Releasing Inc. | false |
