| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Wallace & Gromit: The Curse of the Were-Rabbit | - | - | - | $2,715,854 | 3,656 | $56,110,897 | Oct 5 | DreamWorks Distribution | false |
| 2 | Flightplan | - | - | - | $1,322,928 | 3,424 | $89,707,299 | Sep 23 | Walt Disney Studios Motion Pictures | false |
| 3 | In Her Shoes | - | - | - | $1,280,515 | 2,840 | $32,880,591 | Oct 7 | Twentieth Century Fox | false |
| 4 | Two for the Money | - | - | - | $1,111,815 | 2,397 | $22,991,379 | Oct 7 | Universal Pictures | false |
| 5 | Corpse Bride | - | - | - | $922,339 | 3,204 | $53,359,111 | Sep 16 | Warner Bros. | false |
| 6 | Waiting... | - | - | - | $851,281 | 1,652 | $16,124,543 | Oct 7 | Lionsgate | false |
| 7 | A History of Violence | - | - | - | $759,000 | 1,348 | $31,504,633 | Sep 23 | New Line Cinema | true |
| 8 | Serenity | - | - | - | $700,480 | 2,189 | $25,514,517 | Sep 30 | Universal Pictures | false |
| 9 | The Gospel | - | - | - | $668,408 | 983 | $15,778,152 | Oct 7 | Screen Gems | false |
| 10 | The Greatest Game Ever Played | - | - | - | $637,198 | 1,810 | $15,337,393 | Sep 30 | Walt Disney Studios Motion Pictures | false |
| 11 | Into the Blue | - | - | - | $575,930 | 2,789 | $18,801,234 | Sep 30 | Sony Pictures Releasing | false |
| 12 | Just Like Heaven | - | - | - | $428,433 | 3,543 | $48,318,130 | Sep 16 | DreamWorks Distribution | false |
| 13 | The Exorcism of Emily Rose | - | - | - | $254,298 | 3,045 | $75,072,454 | Sep 9 | Screen Gems | false |
| 14 | The 40-Year-Old Virgin | - | - | - | $220,740 | 3,006 | $109,449,237 | Aug 19 | Universal Pictures | false |
| 15 | Roll Bounce | - | - | - | $210,720 | 1,661 | $17,380,866 | Sep 23 | Fox Searchlight Pictures | false |
| 16 | The Constant Gardener | - | - | - | $118,880 | 1,387 | $33,579,797 | Aug 31 | Focus Features | false |
| 17 | Lord of War | - | - | - | $110,977 | 2,814 | $24,149,632 | Sep 16 | Lionsgate | false |
| 18 | Oliver Twist | - | - | - | $89,222 | 779 | $2,080,321 | Sep 23 | Sony Pictures Releasing | false |
| 19 | March of the Penguins | - | - | - | $85,125 | 2,506 | $77,437,223 | Jun 24 | Warner Independent Pictures (WIP) | false |
| 20 | Good Night, and Good Luck. | - | - | - | $67,504 | 929 | $31,558,003 | Oct 7 | Warner Independent Pictures (WIP) | false |
| 21 | Capote | - | - | - | $55,372 | 1,239 | $28,750,530 | Sep 30 | Sony Pictures Classics | false |
| 22 | Charlie and the Chocolate Factory | - | - | - | $53,796 | 3,790 | $206,459,076 | Jul 15 | Warner Bros. | false |
| 23 | Transporter 2 | - | - | - | $36,646 | 3,320 | $43,095,856 | Sep 2 | Twentieth Century Fox | false |
| 24 | Madagascar | - | - | - | $29,856 | 4,142 | $193,595,521 | May 27 | DreamWorks Distribution | false |
| 25 | Everything Is Illuminated | - | - | - | $29,511 | 110 | $1,712,337 | Sep 16 | Warner Independent Pictures (WIP) | false |
| 26 | War of the Worlds | - | - | - | $28,533 | 3,910 | $234,280,354 | Jun 29 | Paramount Pictures | false |
| 27 | Four Brothers | - | - | - | $22,537 | 2,649 | $74,494,381 | Aug 12 | Paramount Pictures | false |
| 28 | Fantastic Four | - | - | - | $20,700 | 3,619 | $154,696,080 | Jul 8 | Twentieth Century Fox | false |
| 29 | Separate Lies | - | - | - | $18,831 | 127 | $924,260 | Sep 16 | Fox Searchlight Pictures | false |
| 30 | Mr. & Mrs. Smith | - | - | - | $16,989 | 3,451 | $186,336,279 | Jun 10 | Twentieth Century Fox | false |
| 31 | Grizzly Man | - | - | - | $15,476 | 105 | $3,178,403 | Aug 12 | Lionsgate | false |
| 32 | The Prize Winner of Defiance, Ohio | - | - | - | $13,619 | 41 | $627,844 | Sep 30 | DreamWorks Distribution | false |
| 33 | The Dukes of Hazzard | - | - | - | $12,103 | 3,785 | $80,270,227 | Aug 5 | Warner Bros. | false |
| 34 | Red Eye | - | - | - | $8,798 | 3,134 | $57,891,803 | Aug 19 | DreamWorks Distribution | false |
| 35 | The Skeleton Key | - | - | - | $8,690 | 2,784 | $47,907,715 | Aug 12 | Universal Pictures | false |
| 36 | Batman Begins | - | - | - | $8,062 | 3,858 | $205,343,774 | Jun 15 | Warner Bros. | false |
| 37 | Little Manhattan | - | - | - | $6,842 | 35 | $385,373 | Sep 30 | Twentieth Century Fox | false |
| 38 | Star Wars: Episode III - Revenge of the Sith | - | - | - | $5,797 | 3,663 | $380,270,577 | May 19 | Twentieth Century Fox | false |
| 39 | Duma | - | - | - | $5,795 | 42 | $870,067 | Apr 22 | Warner Bros. | false |
| 40 | Must Love Dogs | - | - | - | $1,576 | 2,505 | $43,894,863 | Jul 29 | Warner Bros. | false |
| 41 | Mad Hot Ballroom | - | - | - | $1,158 | 202 | $8,117,961 | May 13 | Paramount Classics | false |
| 42 | Hustle & Flow | - | - | - | $510 | 1,016 | $22,202,809 | Jul 22 | Paramount Classics | false |
| 43 | Après Vous | - | - | - | $65 | 42 | $830,292 | Jun 3 | Paramount Classics | false |
| 44 | Cinderella Man | - | - | - | $60 | 2,820 | $61,649,911 | Jun 3 | Universal Pictures | false |
| 45 | Asylum | - | - | - | $10 | 55 | $375,403 | Aug 12 | Paramount Classics | false |
