| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $42,212,651 | 3,768 | $250,863,268 | Dec 22 | Twentieth Century Fox | false |
| 2 | The Pursuit of Happyness | - | - | - | $22,554,220 | 3,169 | $163,566,459 | Dec 15 | Sony Pictures Releasing | false |
| 3 | Rocky Balboa | - | - | - | $17,003,904 | 3,019 | $70,270,943 | Dec 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 4 | The Good Shepherd | - | - | - | $14,142,760 | 2,250 | $59,952,835 | Dec 22 | Universal Pictures | false |
| 5 | Charlotte's Web | - | - | - | $9,568,033 | 3,745 | $82,985,708 | Dec 15 | Paramount Pictures | false |
| 6 | Eragon | - | - | - | $9,334,259 | 3,030 | $75,030,163 | Dec 15 | Twentieth Century Fox | false |
| 7 | Dreamgirls | - | - | - | $8,953,734 | 2,797 | $103,365,956 | Dec 15 | DreamWorks | false |
| 8 | We Are Marshall | - | - | - | $8,582,508 | 2,606 | $43,545,364 | Dec 22 | Warner Bros. | false |
| 9 | The Holiday | - | - | - | $6,855,456 | 2,698 | $63,224,849 | Dec 8 | Sony Pictures Releasing | false |
| 10 | Happy Feet | - | - | - | $6,565,747 | 3,804 | $198,000,317 | Nov 17 | Warner Bros. | false |
| 11 | The Nativity Story | - | - | - | $6,137,619 | 3,083 | $37,629,831 | Dec 1 | New Line Cinema | true |
| 12 | Blood Diamond | - | - | - | $4,775,689 | 1,920 | $57,377,916 | Dec 8 | Warner Bros. | false |
| 13 | Apocalypto | - | - | - | $4,479,914 | 2,465 | $50,866,635 | Dec 8 | Walt Disney Studios Motion Pictures | false |
| 14 | Casino Royale | - | - | - | $4,350,706 | 3,443 | $167,445,960 | Nov 17 | Sony Pictures Releasing | false |
| 15 | Black Christmas | - | - | - | $3,307,602 | 1,544 | $16,273,581 | Dec 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 16 | The Santa Clause 3: The Escape Clause | - | - | - | $1,319,624 | 3,458 | $84,500,122 | Nov 3 | Walt Disney Studios Motion Pictures | false |
| 17 | Unaccompanied Minors | - | - | - | $1,069,848 | 2,775 | $16,655,224 | Dec 8 | Warner Bros. | false |
| 18 | Deja Vu | - | - | - | $1,043,787 | 3,108 | $64,038,616 | Nov 22 | Walt Disney Studios Motion Pictures | false |
| 19 | Borat | - | - | - | $801,273 | 2,611 | $128,505,958 | Nov 3 | Twentieth Century Fox | false |
| 20 | Curse of the Golden Flower | - | - | - | $711,336 | 1,234 | $6,566,773 | Dec 21 | Sony Pictures Classics | false |
| 21 | Volver | - | - | - | $633,815 | 689 | $12,899,867 | Nov 3 | Sony Pictures Classics | false |
| 22 | Deck the Halls | - | - | - | $627,561 | 3,205 | $35,093,569 | Nov 22 | Twentieth Century Fox | false |
| 23 | The Queen | - | - | - | $604,776 | 1,850 | $56,441,711 | Sep 30 | Miramax | false |
| 24 | Babel | - | - | - | $436,801 | 1,251 | $34,302,837 | Oct 27 | Paramount Vantage | false |
| 25 | Bhagam Bhag | - | - | - | $400,127 | 51 | $789,963 | Dec 22 | Rainbow Releasing | false |
| 26 | The History Boys | - | - | - | $388,225 | 165 | $2,706,659 | Nov 21 | Fox Searchlight Pictures | false |
| 27 | The Polar Express 2006 IMAX Release | - | - | - | $359,052 | 37 | $2,940,722 | Nov 17 | Warner Bros. | false |
| 28 | The Departed | - | - | - | $293,644 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 29 | Children of Men | - | - | - | $179,268 | 1,524 | $35,552,383 | Dec 25 | Universal Pictures | false |
| 30 | Little Children | - | - | - | $135,569 | 115 | $5,463,019 | Oct 6 | New Line Cinema | false |
| 31 | The Good German | - | - | - | $135,356 | 66 | $1,308,696 | Dec 15 | Warner Bros. | false |
| 32 | Letters from Iwo Jima | - | - | - | $122,548 | 781 | $13,756,082 | Dec 20 | Warner Bros. | false |
| 33 | The Prestige | - | - | - | $118,607 | 2,305 | $53,089,891 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 34 | Santa vs. the Snowman 3D 2006 Re-release | - | - | - | $74,570 | 29 | $928,275 | Oct 30 | IMAX | false |
| 35 | For Your Consideration | - | - | - | $74,061 | 625 | $5,549,923 | Nov 17 | Warner Independent Pictures (WIP) | false |
| 36 | The Painted Veil | - | - | - | $71,814 | 287 | $8,060,487 | Dec 20 | Warner Independent Pictures (WIP) | false |
| 37 | Sweet Land | - | - | - | $66,879 | 47 | $1,706,325 | Oct 13 | Libero | false |
| 38 | Guadalupe: El Milagro Y El Mensaje | - | - | - | $66,551 | 225 | $848,139 | Dec 8 | Slowhand Cinema Releasing | false |
| 39 | Magnificent Desolation: Walking on the Moon | - | - | - | $64,366 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 40 | Deep Sea | - | - | - | $62,666 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 41 | Bobby | - | - | - | $58,915 | 1,670 | $11,242,801 | Nov 17 | Metro-Goldwyn-Mayer (MGM) | false |
| 42 | Turistas | - | - | - | $50,432 | 1,572 | $7,027,762 | Dec 1 | Fox Atomic | false |
| 43 | Kabul Express | - | - | - | $49,503 | 50 | $302,458 | Dec 15 | Yash Raj Films | false |
| 44 | Venus | - | - | - | $48,871 | 168 | $3,347,411 | Dec 21 | Miramax | false |
| 45 | Little Miss Sunshine | - | - | - | $48,239 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 46 | Dhoom 2 | - | - | - | $38,269 | 63 | $2,643,586 | Nov 23 | Yash Raj Films | false |
| 47 | The Fountain | - | - | - | $36,578 | 1,472 | $10,144,010 | Nov 22 | Warner Bros. | false |
| 48 | Roving Mars | - | - | - | $32,592 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 49 | The Guardian | - | - | - | $32,257 | 3,241 | $55,011,732 | Sep 29 | Walt Disney Studios Motion Pictures | false |
| 50 | The Wedding Weekend | - | - | - | $28,540 | 84 | $1,232,961 | Oct 27 | The Weinstein Company | false |
| 51 | The Nightmare Before Christmas 2006 3D Release | - | - | - | $24,502 | 168 | $8,700,869 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 52 | The Last King of Scotland | - | - | - | $21,256 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 53 | The Illusionist | - | - | - | $20,803 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 54 | Flicka | - | - | - | $20,705 | 2,877 | $21,000,147 | Oct 20 | Twentieth Century Fox | false |
| 55 | Facing the Giants | - | - | - | $18,853 | 441 | $10,178,331 | Sep 29 | IDP Distribution | false |
| 56 | The Work and the Glory III: A House Divided | - | - | - | $17,748 | 44 | $1,325,092 | Nov 22 | Excel Entertainment | false |
| 57 | The Marine | - | - | - | $17,181 | 2,545 | $18,844,784 | Oct 13 | Twentieth Century Fox | false |
| 58 | Tenacious D in the Pick of Destiny | - | - | - | $16,501 | 1,919 | $8,334,575 | Nov 22 | New Line Cinema | false |
| 59 | The Texas Chainsaw Massacre: The Beginning | - | - | - | $13,438 | 2,820 | $39,517,763 | Oct 6 | New Line Cinema | false |
| 60 | A Good Year | - | - | - | $8,792 | 2,067 | $7,459,300 | Nov 10 | Twentieth Century Fox | false |
| 61 | Shortbus | - | - | - | $8,666 | 70 | $1,985,292 | Oct 4 | THINKFilm | false |
| 62 | Screamers | - | - | - | $7,566 | 4 | $52,034 | Dec 8 | Maya Entertainment | false |
| 63 | Copying Beethoven | - | - | - | $7,562 | 29 | $384,029 | Nov 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 64 | The Secret Life of Words | - | - | - | $6,156 | 3 | $20,678 | Dec 15 | Strand Releasing | false |
| 65 | The Young Lieutenant | - | - | - | $6,121 | 3 | $216,724 | Sep 8 | The Cinema Guild | false |
| 66 | Notes on a Scandal | - | - | - | $6,117 | 682 | $17,510,118 | Dec 25 | Fox Searchlight Pictures | false |
| 67 | Jesus Camp | - | - | - | $6,022 | 52 | $902,544 | Sep 15 | Magnolia Pictures | false |
| 68 | Keeping Mum | - | - | - | $5,198 | 79 | $1,619,466 | Sep 15 | THINKFilm | false |
| 69 | Family Law | - | - | - | $4,685 | 6 | $38,605 | Dec 6 | IFC Films | false |
| 70 | 2 or 3 Things I Know About Her | - | - | - | $4,412 | 2 | $104,038 | Nov 17 | Rialto Pictures | false |
| 71 | Van Wilder: The Rise of Taj | - | - | - | $4,095 | 1,979 | $4,300,645 | Dec 1 | Metro-Goldwyn-Mayer (MGM) | false |
| 72 | Galapagos | - | - | - | $3,858 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 73 | Mrs Palfrey at the Claremont | - | - | - | $3,658 | 22 | $1,720,953 | Nov 25 | Cineville | false |
| 74 | American Hardcore | - | - | - | $3,619 | 19 | $279,665 | Sep 22 | Sony Pictures Classics | false |
| 75 | Fast Food Nation | - | - | - | $3,224 | 321 | $1,005,539 | Nov 17 | Fox Searchlight Pictures | false |
| 76 | Aliens of the Deep | - | - | - | $3,197 | 27 | $8,968,684 | Jan 28 | Walt Disney Studios Motion Pictures | false |
| 77 | Words of My Perfect Teacher | - | - | - | $2,800 | 3 | $20,318 | Dec 22 | International Film Circuit | false |
| 78 | Driving Lessons | - | - | - | $2,793 | 21 | $239,962 | Oct 13 | Sony Pictures Classics | false |
| 79 | The Cave of the Yellow Dog | - | - | - | $2,116 | 11 | $141,803 | Nov 10 | Tartan | false |
| 80 | Matthew Barney: No Restraint | - | - | - | $1,796 | 6 | $16,136 | Dec 20 | IFC Films | false |
| 81 | The Aura | - | - | - | $1,718 | 4 | $58,804 | Nov 15 | IFC Films | false |
| 82 | Off the Black | - | - | - | $1,418 | 4 | $24,425 | Dec 8 | THINKFilm | false |
| 83 | Candy | - | - | - | $1,250 | 12 | $45,128 | Nov 17 | THINKFilm | false |
| 84 | Cocaine Cowboys | - | - | - | $1,245 | 14 | $150,056 | Oct 27 | Magnolia Pictures | false |
| 85 | Flannel Pajamas | - | - | - | $1,190 | 4 | $123,301 | Nov 15 | Gigantic Pictures | false |
| 86 | A Soap | - | - | - | $1,093 | 2 | $4,164 | Nov 3 | Strand Releasing | false |
| 87 | Riding Alone for Thousands of Miles | - | - | - | $937 | 13 | $252,325 | Sep 1 | Sony Pictures Classics | false |
| 88 | Samoan Wedding | - | - | - | $895 | 3 | $72,244 | Nov 10 | Magnolia Pictures | false |
| 89 | El Topo | - | - | - | $720 | 4 | $80,302 | Dec 13 | ABKCO Films | false |
| 90 | Opal Dream | - | - | - | $700 | 4 | $14,443 | Nov 22 | Strand Releasing | false |
| 91 | The Bridge | - | - | - | $691 | 19 | $179,780 | Oct 27 | First Stripe Productions | false |
| 92 | Old Joy | - | - | - | $487 | 12 | $255,923 | Aug 25 | Kino International | false |
