| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Night at the Museum | - | - | - | $11,464,626 | 3,768 | $250,863,268 | Dec 22 | Twentieth Century Fox | false |
| 2 | The Pursuit of Happyness | - | - | - | $6,098,747 | 3,169 | $163,566,459 | Dec 15 | Sony Pictures Releasing | false |
| 3 | Dreamgirls | - | - | - | $4,284,161 | 2,797 | $103,365,956 | Dec 15 | DreamWorks | false |
| 4 | Charlotte's Web | - | - | - | $3,267,534 | 3,745 | $82,985,708 | Dec 15 | Paramount Pictures | false |
| 5 | The Good Shepherd | - | - | - | $3,239,125 | 2,250 | $59,952,835 | Dec 22 | Universal Pictures | false |
| 6 | Rocky Balboa | - | - | - | $3,206,734 | 3,019 | $70,270,943 | Dec 20 | Metro-Goldwyn-Mayer (MGM) | false |
| 7 | Eragon | - | - | - | $2,637,194 | 3,030 | $75,030,163 | Dec 15 | Twentieth Century Fox | false |
| 8 | Happy Feet | - | - | - | $2,358,270 | 3,804 | $198,000,317 | Nov 17 | Warner Bros. | false |
| 9 | We Are Marshall | - | - | - | $2,343,500 | 2,606 | $43,545,364 | Dec 22 | Warner Bros. | false |
| 10 | The Holiday | - | - | - | $2,119,510 | 2,698 | $63,224,849 | Dec 8 | Sony Pictures Releasing | false |
| 11 | Blood Diamond | - | - | - | $1,868,564 | 1,920 | $57,377,916 | Dec 8 | Warner Bros. | false |
| 12 | Casino Royale | - | - | - | $1,412,850 | 3,443 | $167,445,960 | Nov 17 | Sony Pictures Releasing | false |
| 13 | Apocalypto | - | - | - | $1,361,101 | 2,465 | $50,866,635 | Dec 8 | Walt Disney Studios Motion Pictures | false |
| 14 | Black Christmas | - | - | - | $1,213,380 | 1,544 | $16,273,581 | Dec 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 15 | The Nativity Story | - | - | - | $449,967 | 3,083 | $37,629,831 | Dec 1 | New Line Cinema | false |
| 16 | Unaccompanied Minors | - | - | - | $314,586 | 2,775 | $16,655,224 | Dec 8 | Warner Bros. | false |
| 17 | The Queen | - | - | - | $283,403 | 1,850 | $56,441,711 | Sep 30 | Miramax | false |
| 18 | Deja Vu | - | - | - | $276,706 | 3,108 | $64,038,616 | Nov 22 | Walt Disney Studios Motion Pictures | false |
| 19 | Pan's Labyrinth | - | - | - | $210,786 | 1,143 | $37,634,615 | Dec 29 | Picturehouse | false |
| 20 | Volver | - | - | - | $209,861 | 689 | $12,899,867 | Nov 3 | Sony Pictures Classics | false |
| 21 | Children of Men | - | - | - | $201,979 | 1,524 | $35,552,383 | Dec 25 | Universal Pictures | false |
| 22 | Borat | - | - | - | $188,175 | 2,611 | $128,505,958 | Nov 3 | Twentieth Century Fox | false |
| 23 | Babel | - | - | - | $179,842 | 1,251 | $34,302,837 | Oct 27 | Paramount Vantage | false |
| 24 | Curse of the Golden Flower | - | - | - | $172,054 | 1,234 | $6,566,773 | Dec 21 | Sony Pictures Classics | false |
| 25 | Notes on a Scandal | - | - | - | $144,624 | 682 | $17,510,118 | Dec 25 | Fox Searchlight Pictures | false |
| 26 | The Painted Veil | - | - | - | $127,114 | 287 | $8,060,487 | Dec 20 | Warner Independent Pictures (WIP) | false |
| 27 | The Santa Clause 3: The Escape Clause | - | - | - | $123,645 | 3,458 | $84,500,122 | Nov 3 | Walt Disney Studios Motion Pictures | false |
| 28 | The Departed | - | - | - | $116,676 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 29 | The History Boys | - | - | - | $115,270 | 165 | $2,706,659 | Nov 21 | Fox Searchlight Pictures | false |
| 30 | Deck the Halls | - | - | - | $69,054 | 3,205 | $35,093,569 | Nov 22 | Twentieth Century Fox | false |
| 31 | The Good German | - | - | - | $42,115 | 66 | $1,308,696 | Dec 15 | Warner Bros. | false |
| 32 | Letters from Iwo Jima | - | - | - | $33,272 | 781 | $13,756,082 | Dec 20 | Warner Bros. | false |
| 33 | The Polar Express 2006 IMAX Release | - | - | - | $25,442 | 37 | $2,940,722 | Nov 17 | Warner Bros. | false |
| 34 | Perfume: The Story of a Murderer | - | - | - | $18,444 | 280 | $2,223,293 | Dec 27 | DreamWorks | false |
| 35 | For Your Consideration | - | - | - | $14,707 | 625 | $5,549,923 | Nov 17 | Warner Independent Pictures (WIP) | false |
| 36 | Deep Sea | - | - | - | $14,537 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 37 | Little Miss Sunshine | - | - | - | $12,001 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 38 | Bobby | - | - | - | $11,682 | 1,670 | $11,242,801 | Nov 17 | Metro-Goldwyn-Mayer (MGM) | false |
| 39 | Flicka | - | - | - | $11,676 | 2,877 | $21,000,147 | Oct 20 | Twentieth Century Fox | false |
| 40 | The Last King of Scotland | - | - | - | $8,694 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 41 | The Illusionist | - | - | - | $7,724 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 42 | Turistas | - | - | - | $7,602 | 1,572 | $7,027,762 | Dec 1 | Fox Atomic | false |
| 43 | The Marine | - | - | - | $6,457 | 2,545 | $18,844,784 | Oct 13 | Twentieth Century Fox | false |
| 44 | The Fountain | - | - | - | $6,313 | 1,472 | $10,144,010 | Nov 22 | Warner Bros. | false |
| 45 | The Wedding Weekend | - | - | - | $6,093 | 84 | $1,232,961 | Oct 27 | The Weinstein Company | false |
| 46 | Miss Potter | - | - | - | $3,552 | 102 | $3,005,605 | Dec 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 47 | A Good Year | - | - | - | $2,845 | 2,067 | $7,459,300 | Nov 10 | Twentieth Century Fox | false |
| 48 | Copying Beethoven | - | - | - | $1,750 | 29 | $384,029 | Nov 10 | Metro-Goldwyn-Mayer (MGM) | false |
| 49 | Van Wilder: The Rise of Taj | - | - | - | $971 | 1,979 | $4,300,645 | Dec 1 | Metro-Goldwyn-Mayer (MGM) | false |
| 50 | Fast Food Nation | - | - | - | $828 | 321 | $1,005,539 | Nov 17 | Fox Searchlight Pictures | false |
