| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | This Is It | - | - | - | $7,075,741 | 3,481 | $72,091,016 | Oct 28 | Sony Pictures Releasing | false |
| 2 | Paranormal Activity | - | - | - | $6,576,554 | 2,712 | $107,918,810 | Sep 25 | Paramount Pictures | false |
| 3 | Law Abiding Citizen | - | - | - | $2,752,122 | 2,890 | $73,357,727 | Oct 16 | Overture Films | false |
| 4 | Couples Retreat | - | - | - | $2,224,110 | 3,074 | $109,204,945 | Oct 9 | Universal Pictures | false |
| 5 | Saw VI | - | - | - | $2,095,785 | 3,036 | $27,693,292 | Oct 23 | Lionsgate | false |
| 6 | Where the Wild Things Are | - | - | - | $1,684,455 | 3,735 | $77,233,467 | Oct 16 | Warner Bros. | false |
| 7 | Amelia | - | - | - | $1,245,255 | 1,070 | $14,246,488 | Oct 23 | Fox Searchlight Pictures | false |
| 8 | The Stepfather | - | - | - | $1,173,485 | 2,734 | $29,062,561 | Oct 16 | Screen Gems | false |
| 9 | Cirque du Freak: The Vampire's Assistant | - | - | - | $1,074,440 | 2,754 | $13,869,515 | Oct 23 | Universal Pictures | false |
| 10 | Zombieland | - | - | - | $995,676 | 3,171 | $75,590,286 | Oct 2 | Sony Pictures Releasing | false |
| 11 | Astro Boy | - | - | - | $967,982 | 3,020 | $19,551,067 | Oct 23 | Summit Entertainment | false |
| 12 | Cloudy with a Chance of Meatballs | - | - | - | $798,784 | 3,119 | $124,870,275 | Sep 18 | Sony Pictures Releasing | false |
| 13 | A Serious Man | - | - | - | $439,614 | 262 | $9,228,768 | Oct 2 | Focus Features | false |
| 14 | Halloween II | - | - | - | $191,932 | 3,088 | $33,392,973 | Aug 28 | Dimension Films | false |
| 15 | Good Hair | - | - | - | $164,154 | 466 | $4,157,223 | Oct 9 | Roadside Attractions | false |
| 16 | Capitalism: A Love Story | - | - | - | $149,140 | 995 | $14,363,397 | Sep 23 | Overture Films | false |
| 17 | The Invention of Lying | - | - | - | $140,228 | 1,743 | $18,451,251 | Oct 2 | Warner Bros. | false |
| 18 | The Boondock Saints II: All Saints Day | - | - | - | $117,581 | 524 | $10,273,188 | Oct 30 | Apparition | false |
| 19 | The Informant! | - | - | - | $82,450 | 2,505 | $33,316,821 | Sep 18 | Warner Bros. | false |
| 20 | London Dreams | - | - | - | $76,373 | 82 | $300,293 | Oct 30 | Studio 18 | false |
| 21 | Whip It | - | - | - | $65,473 | 1,738 | $13,043,363 | Oct 2 | Fox Searchlight Pictures | false |
| 22 | New York, I Love You | - | - | - | $57,686 | 118 | $1,588,015 | Oct 16 | Vivendi Entertainment | false |
| 23 | Bright Star | - | - | - | $54,293 | 380 | $4,444,637 | Sep 16 | Apparition | false |
| 24 | Julie & Julia | - | - | - | $47,872 | 2,528 | $94,125,426 | Aug 7 | Sony Pictures Releasing | false |
| 25 | Inglourious Basterds | - | - | - | $42,230 | 3,358 | $120,540,719 | Aug 21 | The Weinstein Company | false |
| 26 | The Hangover | - | - | - | $39,407 | 3,545 | $277,322,503 | Jun 5 | Warner Bros. | false |
| 27 | The Time Traveler's Wife | - | - | - | $37,768 | 2,988 | $63,414,846 | Aug 14 | Warner Bros. | false |
| 28 | The Final Destination | - | - | - | $34,297 | 3,121 | $66,477,700 | Aug 28 | Warner Bros. | false |
| 29 | Harry Potter and the Half-Blood Prince | - | - | - | $34,101 | 4,455 | $301,959,197 | Jul 15 | Warner Bros. | false |
| 30 | Love Happens | - | - | - | $32,130 | 1,922 | $22,965,110 | Sep 18 | Universal Pictures | false |
| 31 | G.I. Joe: The Rise of Cobra | - | - | - | $30,292 | 4,007 | $150,201,498 | Aug 7 | Paramount Pictures | false |
| 32 | District 9 | - | - | - | $29,264 | 3,180 | $115,646,235 | Aug 14 | TriStar Pictures | false |
| 33 | All About Steve | - | - | - | $26,103 | 2,265 | $33,862,903 | Sep 4 | Twentieth Century Fox | false |
| 34 | The Boys Are Back | - | - | - | $22,603 | 108 | $809,752 | Sep 25 | Miramax | false |
| 35 | The Maid | - | - | - | $21,439 | 19 | $576,608 | Oct 16 | Elephant Eye Films | false |
| 36 | More Than a Game | - | - | - | $20,614 | 111 | $950,675 | Oct 2 | Lionsgate | false |
| 37 | Ice Age: Dawn of the Dinosaurs | - | - | - | $20,422 | 4,102 | $196,573,705 | Jul 1 | Twentieth Century Fox | false |
| 38 | Pandorum | - | - | - | $19,405 | 2,506 | $10,330,853 | Sep 25 | Overture Films | false |
| 39 | The September Issue | - | - | - | $19,164 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 40 | Fame | - | - | - | $18,458 | 3,133 | $22,455,510 | Sep 25 | Metro-Goldwyn-Mayer (MGM) | false |
| 41 | Under the Sea 3D | - | - | - | $17,893 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 42 | Jennifer's Body | - | - | - | $10,815 | 2,738 | $16,204,793 | Sep 18 | Twentieth Century Fox | false |
| 43 | 9 | - | - | - | $10,218 | 2,060 | $31,749,894 | Sep 9 | Focus Features | false |
| 44 | Sorority Row | - | - | - | $8,996 | 2,665 | $11,965,282 | Sep 11 | Summit Entertainment | false |
| 45 | 500 Days of Summer | - | - | - | $8,547 | 1,048 | $32,391,374 | Jul 17 | Fox Searchlight Pictures | false |
| 46 | Aliens in the Attic | - | - | - | $7,453 | 3,108 | $25,200,412 | Jul 31 | Twentieth Century Fox | false |
| 47 | My One and Only | - | - | - | $5,578 | 256 | $2,479,538 | Aug 21 | Freestyle Releasing | false |
| 48 | I Hope They Serve Beer in Hell | - | - | - | $2,450 | 266 | $1,429,299 | Sep 25 | Freestyle Releasing | false |
| 49 | Gentlemen Broncos | - | - | - | $2,162 | 18 | $113,682 | Oct 30 | Fox Searchlight Pictures | false |
| 50 | Adam | - | - | - | $1,843 | 177 | $2,277,396 | Jul 29 | Fox Searchlight Pictures | false |
| 51 | Motherhood | - | - | - | $1,568 | 48 | $93,388 | Oct 23 | Freestyle Releasing | false |
| 52 | Wake Up Sid | - | - | - | $1,441 | 79 | $718,766 | Oct 2 | UTV Motion Pictures | false |
| 53 | From Mexico with Love | - | - | - | $1,346 | 279 | $548,787 | Oct 9 | Roadside Attractions | false |
| 54 | Me and Mrs. Khanna | - | - | - | $946 | 59 | $197,183 | Oct 16 | UTV Motion Pictures | false |
| 55 | Shorts | - | - | - | $816 | 3,105 | $20,919,166 | Aug 21 | Warner Bros. | false |
| 56 | American Casino | - | - | - | $795 | 3 | $50,437 | Aug 14 | Argot Pictures | false |
| 57 | Whiteout | - | - | - | $596 | 2,745 | $10,275,638 | Sep 11 | Warner Bros. | false |
| 58 | Bicycle Thieves 2008 Re-release | - | - | - | $513 | 2 | $36,818 | Oct 31 | Corinth Films | false |
| 59 | The Cove | - | - | - | $492 | 56 | $857,005 | Jul 31 | Roadside Attractions | false |
| 60 | The Big Gay Musical | - | - | - | $231 | 1 | $24,140 | Sep 11 | - | false |
| 61 | The Stoning of Soraya M. | - | - | - | $111 | 34 | $637,421 | Jun 26 | Roadside Attractions | false |
