| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Saw V | - | - | - | $3,172,214 | 3,084 | $56,746,769 | Oct 24 | Lionsgate Films | false |
| 2 | Changeling | - | - | - | $2,303,250 | 1,896 | $35,739,802 | Oct 24 | Universal Pictures | false |
| 3 | Zack and Miri Make a Porno | - | - | - | $2,194,513 | 2,735 | $31,457,946 | Oct 31 | The Weinstein Company | false |
| 4 | The Haunting of Molly Hartley | - | - | - | $1,788,263 | 2,652 | $13,559,812 | Oct 31 | Freestyle Releasing | false |
| 5 | High School Musical 3: Senior Year | - | - | - | $1,681,440 | 3,626 | $90,559,416 | Oct 24 | Walt Disney Studios Motion Pictures | false |
| 6 | The Secret Life of Bees | - | - | - | $842,628 | 1,630 | $37,770,162 | Oct 17 | - | false |
| 7 | Pride and Glory | - | - | - | $754,985 | 2,585 | $15,740,721 | Oct 24 | Warner Bros. | false |
| 8 | Max Payne | - | - | - | $751,459 | 3,381 | $40,689,393 | Oct 17 | Twentieth Century Fox | false |
| 9 | Eagle Eye | - | - | - | $697,803 | 3,614 | $101,440,743 | Sep 26 | DreamWorks | false |
| 10 | Beverly Hills Chihuahua | - | - | - | $638,933 | 3,239 | $94,514,402 | Oct 3 | Walt Disney Studios Motion Pictures | false |
| 11 | Body of Lies | - | - | - | $536,619 | 2,714 | $39,394,666 | Oct 10 | Warner Bros. | false |
| 12 | W. | - | - | - | $518,175 | 2,050 | $25,534,493 | Oct 17 | Lionsgate Films | false |
| 13 | RocknRolla | - | - | - | $425,736 | 826 | $5,700,626 | Oct 8 | Warner Bros. | false |
| 14 | Fireproof | - | - | - | $420,895 | 905 | $33,456,317 | Sep 26 | The Samuel Goldwyn Company | false |
| 15 | Quarantine | - | - | - | $333,453 | 2,463 | $31,691,811 | Oct 10 | Screen Gems | false |
| 16 | Appaloosa | - | - | - | $220,187 | 1,290 | $20,211,394 | Sep 19 | Warner Bros. | false |
| 17 | The Duchess | - | - | - | $136,324 | 1,207 | $13,848,978 | Sep 19 | Paramount Vantage | false |
| 18 | Nights in Rodanthe | - | - | - | $131,099 | 2,704 | $41,850,659 | Sep 26 | Warner Bros. | false |
| 19 | Religulous | - | - | - | $108,273 | 568 | $13,011,160 | Oct 1 | Lionsgate Films | false |
| 20 | Nick and Norah's Infinite Playlist | - | - | - | $106,330 | 2,421 | $31,487,293 | Oct 3 | Sony Pictures Releasing | false |
| 21 | Burn After Reading | - | - | - | $93,450 | 2,657 | $60,355,347 | Sep 12 | Focus Features | false |
| 22 | The Nightmare Before Christmas 2009 3D Release | - | - | - | $71,254 | 284 | $1,109,188 | Oct 24 | Walt Disney Studios Motion Pictures | false |
| 23 | Sex Drive | - | - | - | $68,430 | 2,421 | $8,402,485 | Oct 17 | Summit Entertainment | false |
| 24 | Happy-Go-Lucky | - | - | - | $54,767 | 202 | $3,512,016 | Oct 10 | Miramax | false |
| 25 | The Dark Knight | - | - | - | $49,209 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 26 | City of Ember | - | - | - | $43,121 | 2,023 | $7,873,007 | Oct 10 | Twentieth Century Fox | false |
| 27 | Lakeview Terrace | - | - | - | $39,102 | 2,574 | $39,263,506 | Sep 19 | Screen Gems | false |
| 28 | The Express | - | - | - | $38,135 | 2,810 | $9,793,406 | Oct 10 | Universal Pictures | false |
| 29 | Journey to the Center of the Earth | - | - | - | $27,279 | 2,830 | $101,704,370 | Jul 11 | Warner Bros. | false |
| 30 | Mamma Mia! | - | - | - | $24,030 | 3,194 | $144,290,968 | Jul 18 | Universal Pictures | false |
| 31 | Tropic Thunder | - | - | - | $22,034 | 3,473 | $110,515,313 | Aug 13 | DreamWorks | false |
| 32 | Righteous Kill | - | - | - | $17,521 | 3,152 | $40,081,410 | Sep 12 | Overture Films | false |
| 33 | Vicky Cristina Barcelona | - | - | - | $16,392 | 726 | $23,216,709 | Aug 15 | - | false |
| 34 | Noah's Arc: Jumping the Broom | - | - | - | $15,089 | 9 | $532,878 | Oct 24 | - | false |
| 35 | The Other End of the Line | - | - | - | $14,692 | 91 | $115,592 | Oct 31 | Metro-Goldwyn-Mayer (MGM) | false |
| 36 | The Women | - | - | - | $12,847 | 2,995 | $26,902,075 | Sep 12 | Picturehouse | false |
| 37 | Igor | - | - | - | $10,825 | 2,341 | $19,528,602 | Sep 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 38 | Ghost Town | - | - | - | $9,987 | 1,512 | $13,367,624 | Sep 19 | DreamWorks | false |
| 39 | Passengers | - | - | - | $8,791 | 125 | $292,437 | Oct 24 | Sony Pictures Releasing | false |
| 40 | Mirrors | - | - | - | $7,342 | 2,664 | $30,691,439 | Aug 15 | Twentieth Century Fox | false |
| 41 | Deep Sea | - | - | - | $6,620 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 42 | An American Carol | - | - | - | $6,279 | 1,639 | $7,013,191 | Oct 3 | Vivendi Entertainment | false |
| 43 | I.O.U.S.A. | - | - | - | $5,654 | 358 | $821,046 | Aug 22 | Roadside Attractions | false |
| 44 | Get Smart | - | - | - | $5,108 | 3,915 | $130,319,208 | Jun 20 | Warner Bros. | false |
| 45 | My Name Is Bruce | - | - | - | $4,876 | 4 | $173,066 | Oct 31 | Image Entertainment | false |
| 46 | The Longshots | - | - | - | $4,644 | 2,089 | $11,537,046 | Aug 22 | - | false |
| 47 | Star Wars: The Clone Wars | - | - | - | $3,129 | 3,452 | $35,161,554 | Aug 15 | Warner Bros. | false |
| 48 | Traitor | - | - | - | $2,893 | 2,108 | $23,530,831 | Aug 27 | Overture Films | false |
| 49 | Hounddog | - | - | - | $2,682 | 11 | $131,961 | Sep 19 | Empire Pictures Inc. | false |
| 50 | The Sisterhood of the Traveling Pants 2 | - | - | - | $2,493 | 2,714 | $44,089,964 | Aug 6 | Warner Bros. | false |
| 51 | Fly Me to the Moon 3D | - | - | - | $1,866 | 713 | $13,816,982 | Aug 15 | Summit Entertainment | false |
| 52 | Eden Lake | - | - | - | $1,489 | 10 | $7,321 | Oct 31 | Third Rail Releasing | false |
| 53 | College | - | - | - | $1,289 | 2,124 | $4,694,636 | Aug 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 54 | Choke | - | - | - | $1,000 | 435 | $2,926,565 | Sep 26 | - | false |
| 55 | Lola Montès | - | - | - | $520 | 4 | $120,306 | Oct 10 | Rialto Pictures | false |
| 56 | How to Lose Friends & Alienate People | - | - | - | $426 | 1,750 | $2,778,752 | Oct 3 | Metro-Goldwyn-Mayer (MGM) | false |
| 57 | Call + Response | - | - | - | $295 | 17 | $215,185 | Oct 10 | Fair Trade Pictures | false |
| 58 | The First Basket | - | - | - | $238 | 4 | $20,440 | Oct 29 | - | false |
| 59 | Beer for My Horses | - | - | - | $75 | 91 | $666,045 | Aug 8 | Roadside Attractions | false |
