| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Saw III | - | - | - | $4,505,675 | 3,167 | $80,238,724 | Oct 27 | Lionsgate | false |
| 2 | The Departed | - | - | - | $808,391 | 3,017 | $132,384,315 | Oct 6 | Warner Bros. | false |
| 3 | The Prestige | - | - | - | $776,227 | 2,305 | $53,089,891 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 4 | Flags of Our Fathers | - | - | - | $610,907 | 2,375 | $33,602,376 | Oct 20 | DreamWorks | false |
| 5 | Man of the Year | - | - | - | $367,640 | 2,626 | $37,327,390 | Oct 13 | Universal Pictures | false |
| 6 | Open Season | - | - | - | $334,067 | 3,833 | $85,105,259 | Sep 29 | Sony Pictures Releasing | false |
| 7 | The Grudge 2 | - | - | - | $308,260 | 3,214 | $39,143,839 | Oct 13 | Sony Pictures Releasing | false |
| 8 | Flicka | - | - | - | $268,990 | 2,877 | $21,000,147 | Oct 20 | Twentieth Century Fox | false |
| 9 | The Nightmare Before Christmas 2006 3D Release | - | - | - | $251,591 | 168 | $8,700,869 | Oct 20 | Walt Disney Studios Motion Pictures | false |
| 10 | Marie Antoinette | - | - | - | $223,358 | 870 | $15,962,471 | Oct 20 | Sony Pictures Releasing | false |
| 11 | The Queen | - | - | - | $206,000 | 1,850 | $56,441,711 | Sep 30 | Miramax | true |
| 12 | The Guardian | - | - | - | $201,172 | 3,241 | $55,011,732 | Sep 29 | Walt Disney Studios Motion Pictures | false |
| 13 | Running with Scissors | - | - | - | $183,141 | 586 | $7,022,827 | Oct 20 | Sony Pictures Releasing | false |
| 14 | One Night with the King | - | - | - | $180,237 | 909 | $13,395,961 | Oct 13 | 8x Entertainment | false |
| 15 | The Texas Chainsaw Massacre: The Beginning | - | - | - | $172,000 | 2,820 | $39,517,763 | Oct 6 | New Line Cinema | true |
| 16 | Catch a Fire | - | - | - | $161,000 | 1,306 | $4,299,773 | Oct 27 | Focus Features | true |
| 17 | The Marine | - | - | - | $118,269 | 2,545 | $18,844,784 | Oct 13 | Twentieth Century Fox | false |
| 18 | Employee of the Month | - | - | - | $93,535 | 2,579 | $28,444,855 | Oct 6 | Lionsgate | false |
| 19 | The Illusionist | - | - | - | $53,164 | 1,438 | $39,868,642 | Aug 18 | Yari Film Group Releasing | false |
| 20 | Jackass Number Two | - | - | - | $36,294 | 3,063 | $72,778,712 | Sep 22 | Paramount Pictures | false |
| 21 | Little Miss Sunshine | - | - | - | $32,519 | 1,602 | $59,891,098 | Jul 26 | Fox Searchlight Pictures | false |
| 22 | The Last King of Scotland | - | - | - | $31,783 | 540 | $17,606,684 | Sep 27 | Fox Searchlight Pictures | false |
| 23 | Babel | - | - | - | $30,297 | 1,251 | $34,302,837 | Oct 27 | Paramount Vantage | false |
| 24 | Little Children | - | - | - | $18,000 | 115 | $5,463,019 | Oct 6 | New Line Cinema | true |
| 25 | Deep Sea | - | - | - | $14,824 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 26 | Infamous | - | - | - | $13,279 | 179 | $1,151,330 | Oct 13 | Warner Independent Pictures (WIP) | false |
| 27 | The Science of Sleep | - | - | - | $12,384 | 243 | $4,670,644 | Sep 22 | Warner Independent Pictures (WIP) | false |
| 28 | Barnyard | - | - | - | $9,684 | 3,311 | $72,637,803 | Aug 4 | Paramount Pictures | false |
| 29 | School for Scoundrels | - | - | - | $9,506 | 3,007 | $17,807,569 | Sep 29 | Metro-Goldwyn-Mayer (MGM) | false |
| 30 | The Wicker Man | - | - | - | $7,386 | 2,784 | $23,649,127 | Sep 1 | Warner Bros. | false |
| 31 | The U.S. vs. John Lennon | - | - | - | $6,953 | 65 | $1,109,146 | Sep 15 | Lionsgate | false |
| 32 | Flyboys | - | - | - | $5,358 | 2,033 | $13,090,630 | Sep 22 | Metro-Goldwyn-Mayer (MGM) | false |
| 33 | The Devil Wears Prada | - | - | - | $5,187 | 2,882 | $124,740,460 | Jun 30 | Twentieth Century Fox | false |
| 34 | Deliver Us from Evil | - | - | - | $5,111 | 24 | $201,275 | Oct 13 | Lionsgate | false |
| 35 | The Wedding Weekend | - | - | - | $4,600 | 84 | $1,232,961 | Oct 27 | The Weinstein Company | false |
| 36 | The Protector | - | - | - | $4,140 | 1,541 | $12,044,087 | Sep 8 | Dragon Dynasty | false |
| 37 | Everyone's Hero | - | - | - | $3,993 | 2,898 | $14,523,101 | Sep 15 | Twentieth Century Fox | false |
| 38 | The Ant Bully | - | - | - | $3,118 | 3,050 | $28,142,535 | Jul 28 | Warner Bros. | false |
| 39 | Stormbreaker | - | - | - | $2,549 | 221 | $677,646 | Oct 6 | The Weinstein Company | false |
| 40 | Superman Returns | - | - | - | $2,512 | 4,065 | $200,081,192 | Jun 28 | Warner Bros. | false |
| 41 | Beerfest | - | - | - | $743 | 2,964 | $19,185,184 | Aug 25 | Warner Bros. | false |
| 42 | An Inconvenient Truth | - | - | - | $722 | 587 | $24,146,161 | May 24 | Paramount Classics | false |
