| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Hunger Games | - | - | - | $7,294,332 | 4,137 | $408,010,692 | Mar 23 | Lionsgate Films | false |
| 2 | American Reunion | - | - | - | $4,756,080 | 3,203 | $57,011,521 | Apr 6 | Universal Pictures | false |
| 3 | Wrath of the Titans | - | - | - | $3,653,749 | 3,545 | $83,670,083 | Mar 30 | Warner Bros. | false |
| 4 | Titanic 2012 3D Release | - | - | - | $3,505,870 | 3,674 | $57,884,114 | Apr 4 | Paramount Pictures | false |
| 5 | Mirror Mirror | - | - | - | $2,532,171 | 3,618 | $64,935,167 | Mar 30 | Relativity Media | false |
| 6 | 21 Jump Street | - | - | - | $2,513,935 | 3,148 | $138,447,667 | Mar 16 | Sony Pictures Releasing | false |
| 7 | The Lorax | - | - | - | $1,066,065 | 3,769 | $214,151,550 | Mar 2 | Universal Pictures | false |
| 8 | Salmon Fishing in the Yemen | - | - | - | $246,443 | 524 | $9,047,981 | Mar 9 | CBS Films | false |
| 9 | John Carter | - | - | - | $210,148 | 3,749 | $73,078,100 | Mar 9 | Walt Disney Studios Motion Pictures | false |
| 10 | Journey 2: The Mysterious Island | - | - | - | $131,862 | 3,500 | $103,860,290 | Feb 10 | Warner Bros. | false |
| 11 | Safe House | - | - | - | $130,140 | 3,121 | $126,373,434 | Feb 10 | Universal Pictures | false |
| 12 | A Thousand Words | - | - | - | $123,502 | 1,895 | $18,450,127 | Mar 9 | DreamWorks | false |
| 13 | Act of Valor | - | - | - | $122,444 | 3,053 | $70,012,847 | Feb 24 | Relativity Media | false |
| 14 | Jeff, Who Lives at Home | - | - | - | $111,106 | 513 | $4,269,426 | Mar 16 | Paramount Vantage | false |
| 15 | Casa de mi Padre | - | - | - | $83,692 | 475 | $5,909,483 | Mar 16 | Lionsgate Films | false |
| 16 | Project X | - | - | - | $82,437 | 3,055 | $54,731,865 | Mar 2 | Warner Bros. | false |
| 17 | October Baby 2012 Re-release | - | - | - | $82,000 | 390 | $5,157,886 | Mar 23 | The Samuel Goldwyn Company | true |
| 18 | The Vow | - | - | - | $64,573 | 3,038 | $125,014,030 | Feb 10 | Screen Gems | false |
| 19 | Friends with Kids | - | - | - | $55,749 | 640 | $7,251,073 | Mar 9 | Roadside Attractions | false |
| 20 | This Means War | - | - | - | $50,899 | 3,189 | $54,760,791 | Feb 17 | Twentieth Century Fox | false |
| 21 | The Artist | - | - | - | $48,880 | 1,756 | $44,671,682 | Nov 25 | The Weinstein Company | false |
| 22 | Ghost Rider: Spirit of Vengeance | - | - | - | $48,285 | 3,174 | $51,774,002 | Feb 17 | Sony Pictures Releasing | false |
| 23 | Good Deeds | - | - | - | $40,435 | 2,132 | $35,025,791 | Feb 24 | Lionsgate Films | false |
| 24 | The Iron Lady | - | - | - | $32,204 | 1,244 | $30,017,992 | Dec 30 | The Weinstein Company | false |
| 25 | Chronicle | - | - | - | $30,498 | 2,908 | $64,575,175 | Feb 3 | Twentieth Century Fox | false |
| 26 | Silent House | - | - | - | $28,367 | 2,124 | $12,754,783 | Mar 9 | Open Road Films (II) | false |
| 27 | Alvin and the Chipmunks: Chipwrecked | - | - | - | $24,142 | 3,734 | $133,110,742 | Dec 16 | Twentieth Century Fox | false |
| 28 | Born to Be Wild | - | - | - | $22,345 | 208 | $25,978,556 | Apr 8 | Warner Bros. | false |
| 29 | Bully | - | - | - | $20,222 | 6 | $279,202 | Mar 30 | The Weinstein Company | false |
| 30 | Hugo | - | - | - | $18,895 | 2,608 | $73,864,507 | Nov 23 | Paramount Pictures | false |
| 31 | The Woman in Black | - | - | - | $18,350 | 2,856 | $54,333,290 | Feb 3 | CBS Films | false |
| 32 | Gone | - | - | - | $12,866 | 2,186 | $11,682,205 | Feb 24 | Lionsgate Films | false |
| 33 | Mission: Impossible - Ghost Protocol | - | - | - | $12,403 | 3,555 | $209,397,903 | Dec 16 | Paramount Pictures | false |
| 34 | We Bought a Zoo | - | - | - | $11,538 | 3,170 | $75,624,550 | Dec 23 | Twentieth Century Fox | false |
| 35 | The Descendants | - | - | - | $10,723 | 2,038 | $82,584,160 | Nov 16 | - | false |
| 36 | Star Wars: Episode I - The Phantom Menace 2012 3D Release | - | - | - | $8,592 | 2,655 | $43,456,382 | Feb 10 | Twentieth Century Fox | false |
| 37 | The Grey | - | - | - | $6,658 | 3,208 | $51,580,236 | Jan 27 | Open Road Films (II) | false |
| 38 | Being Flynn | - | - | - | $6,535 | 88 | $540,152 | Mar 2 | Focus Features | false |
| 39 | Coriolanus | - | - | - | $6,483 | 21 | $757,195 | Jan 20 | The Weinstein Company | false |
| 40 | Undefeated | - | - | - | $5,175 | 21 | $562,218 | Feb 17 | The Weinstein Company | false |
| 41 | Chico & Rita | - | - | - | $5,068 | 23 | $350,524 | Feb 10 | GKIDS | false |
| 42 | Red Tails | - | - | - | $5,062 | 2,573 | $49,876,377 | Jan 20 | Twentieth Century Fox | false |
| 43 | W.E. | - | - | - | $4,265 | 24 | $583,455 | Feb 3 | The Weinstein Company | false |
| 44 | One for the Money | - | - | - | $3,584 | 2,737 | $26,414,527 | Jan 27 | Lionsgate Films | false |
| 45 | Albert Nobbs | - | - | - | $2,668 | 245 | $3,014,696 | Jan 27 | Roadside Attractions | false |
