| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Fast & Furious | - | - | - | $6,110,785 | 3,674 | $155,064,265 | Apr 3 | Universal Pictures | false |
| 2 | Monsters vs. Aliens | - | - | - | $4,593,171 | 4,136 | $198,351,526 | Mar 27 | DreamWorks | false |
| 3 | Hannah Montana: The Movie | - | - | - | $4,456,635 | 3,231 | $79,576,189 | Apr 10 | Walt Disney Studios Motion Pictures | false |
| 4 | Observe and Report | - | - | - | $2,406,701 | 2,727 | $24,007,324 | Apr 10 | Warner Bros. | false |
| 5 | Knowing | - | - | - | $1,547,207 | 3,337 | $79,957,634 | Mar 20 | Summit Entertainment | false |
| 6 | I Love You, Man | - | - | - | $1,478,334 | 2,829 | $71,440,011 | Mar 20 | DreamWorks | false |
| 7 | The Haunting in Connecticut | - | - | - | $1,274,445 | 2,732 | $55,389,516 | Mar 27 | Lionsgate Films | false |
| 8 | Dragonball Evolution | - | - | - | $993,847 | 2,181 | $9,362,785 | Apr 10 | Twentieth Century Fox | false |
| 9 | Adventureland | - | - | - | $787,349 | 1,876 | $16,044,025 | Apr 3 | Miramax | false |
| 10 | Duplicity | - | - | - | $648,450 | 2,579 | $40,572,825 | Mar 20 | Universal Pictures | false |
| 11 | Race to Witch Mountain | - | - | - | $428,668 | 3,268 | $67,172,594 | Mar 13 | Walt Disney Studios Motion Pictures | false |
| 12 | Sunshine Cleaning | - | - | - | $402,656 | 642 | $12,062,558 | Mar 13 | Overture Films | false |
| 13 | Taken | - | - | - | $233,679 | 3,184 | $145,000,989 | Jan 30 | Twentieth Century Fox | false |
| 14 | 12 Rounds | - | - | - | $194,632 | 2,331 | $12,234,694 | Mar 27 | Twentieth Century Fox | false |
| 15 | Watchmen | - | - | - | $140,486 | 3,611 | $107,509,799 | Mar 6 | Warner Bros. | false |
| 16 | The Last House on the Left | - | - | - | $133,945 | 2,402 | $32,752,215 | Mar 13 | Universal Pictures | false |
| 17 | Paul Blart: Mall Cop | - | - | - | $132,679 | 3,206 | $146,336,178 | Jan 16 | Sony Pictures Releasing | false |
| 18 | Sin Nombre | - | - | - | $85,457 | 87 | $2,536,665 | Mar 20 | Focus Features | false |
| 19 | Slumdog Millionaire | - | - | - | $68,937 | 2,943 | $141,319,928 | Nov 12 | - | false |
| 20 | Under the Sea 3D | - | - | - | $64,127 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 21 | Gran Torino | - | - | - | $50,998 | 3,045 | $148,095,302 | Dec 12 | Warner Bros. | false |
| 22 | Madea Goes to Jail | - | - | - | $50,485 | 2,203 | $90,508,336 | Feb 20 | Lionsgate Films | false |
| 23 | Coraline | - | - | - | $46,751 | 2,320 | $75,286,229 | Feb 6 | Focus Features | false |
| 24 | Hotel for Dogs | - | - | - | $43,411 | 3,271 | $73,034,460 | Jan 16 | DreamWorks | false |
| 25 | He's Just Not That Into You | - | - | - | $30,886 | 3,175 | $93,953,653 | Feb 6 | Warner Bros. | false |
| 26 | Push | - | - | - | $24,395 | 2,313 | $31,811,527 | Feb 6 | Summit Entertainment | false |
| 27 | The Reader | - | - | - | $24,209 | 1,203 | $34,194,407 | Dec 10 | The Weinstein Company | false |
| 28 | The Curious Case of Benjamin Button | - | - | - | $18,964 | 2,988 | $127,509,326 | Dec 25 | Paramount Pictures | false |
| 29 | Goodbye Solo | - | - | - | $14,955 | 34 | $870,781 | Mar 27 | Roadside Attractions | false |
| 30 | Friday the 13th | - | - | - | $10,875 | 3,105 | $65,002,019 | Feb 13 | Warner Bros. | false |
| 31 | The Wrestler | - | - | - | $9,021 | 776 | $26,238,243 | Dec 17 | - | false |
| 32 | Royal Kill | - | - | - | $8,755 | 5 | $50,090 | Apr 10 | 21st Century Film Production | false |
| 33 | Last Chance Harvey | - | - | - | $8,273 | 1,108 | $14,889,042 | Dec 25 | Overture Films | false |
| 34 | Defiance | - | - | - | $7,507 | 1,793 | $28,644,813 | Dec 31 | Paramount Vantage | false |
| 35 | Bride Wars | - | - | - | $7,359 | 3,228 | $58,715,510 | Jan 9 | Twentieth Century Fox | false |
| 36 | Street Fighter: The Legend of Chun-Li | - | - | - | $5,828 | 1,164 | $8,742,261 | Feb 27 | Twentieth Century Fox | false |
| 37 | Marley & Me | - | - | - | $4,682 | 3,505 | $143,153,751 | Dec 25 | Twentieth Century Fox | false |
| 38 | Fanboys | - | - | - | $3,258 | 45 | $688,529 | Feb 6 | The Weinstein Company | false |
| 39 | Milk | - | - | - | $2,933 | 882 | $31,841,299 | Nov 26 | Focus Features | false |
| 40 | Alien Trespass | - | - | - | $2,881 | 40 | $104,526 | Apr 3 | Roadside Attractions | false |
| 41 | Crossing Over | - | - | - | $2,507 | 42 | $455,654 | Feb 27 | The Weinstein Company | false |
| 42 | Enlighten Up! | - | - | - | $2,428 | 12 | $246,649 | Sep 12 | Balcony Releasing | false |
| 43 | Bart Got a Room | - | - | - | $2,289 | 11 | $53,760 | Apr 3 | Anchor Bay Films | false |
| 44 | Miss March | - | - | - | $1,135 | 1,742 | $4,543,320 | Mar 13 | - | false |
| 45 | Between Love & Goodbye | - | - | - | $434 | 2 | $18,480 | Jan 30 | Embrem Entertainment | false |
| 46 | Made in U.S.A | - | - | - | $370 | 2 | $95,209 | Jan 9 | Rialto Pictures | false |
| 47 | Throw Down Your Heart | - | - | - | $257 | 4 | $89,521 | Mar 13 | Argot Pictures | false |
| 48 | Were the World Mine | - | - | - | $237 | 4 | $123,789 | Oct 31 | - | false |
| 49 | Valkyrie | - | - | - | $164 | 2,838 | $83,077,833 | Dec 25 | United Artists | false |
