| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 2 | Avatar | - | - | - | $23,095,046 | 3,461 | $749,766,139 | Dec 18 | Twentieth Century Fox | false |
| 11 | The Twilight Saga: New Moon | - | - | - | $662,171 | 4,124 | $296,623,634 | Nov 20 | Summit Entertainment | false |
| 6 | The Blind Side | - | - | - | $3,372,405 | 3,407 | $255,959,475 | Nov 20 | Warner Bros. | false |
| 3 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $13,890,011 | 3,747 | $219,614,612 | Dec 23 | Twentieth Century Fox | false |
| 1 | Sherlock Holmes | - | - | - | $24,608,941 | 3,626 | $209,028,679 | Dec 25 | Warner Bros. | false |
| 15 | 2012 | - | - | - | $306,405 | 3,444 | $166,112,167 | Nov 13 | Sony Pictures Releasing | false |
| 13 | A Christmas Carol | - | - | - | $465,998 | 3,683 | $137,855,863 | Nov 6 | Walt Disney Studios Motion Pictures | false |
| 25 | Cloudy with a Chance of Meatballs | - | - | - | $47,166 | 3,119 | $124,870,275 | Sep 18 | Sony Pictures Releasing | false |
| 4 | It's Complicated | - | - | - | $7,174,195 | 2,955 | $112,735,375 | Dec 25 | Universal Pictures | false |
| 28 | Couples Retreat | - | - | - | $35,650 | 3,074 | $109,204,945 | Oct 9 | Universal Pictures | false |
| 33 | Paranormal Activity | - | - | - | $17,866 | 2,712 | $107,918,810 | Sep 25 | Paramount Pictures | false |
| 8 | The Princess and the Frog | - | - | - | $1,955,703 | 3,475 | $104,400,899 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 5 | Up in the Air | - | - | - | $3,643,812 | 2,218 | $83,823,381 | Dec 4 | Paramount Pictures | false |
| 26 | Where the Wild Things Are | - | - | - | $42,425 | 3,735 | $77,233,467 | Oct 16 | Warner Bros. | false |
| 27 | Law Abiding Citizen | - | - | - | $35,942 | 2,890 | $73,357,727 | Oct 16 | Overture Films | false |
| 17 | Old Dogs | - | - | - | $198,277 | 3,425 | $49,492,060 | Nov 25 | Walt Disney Studios Motion Pictures | false |
| 16 | Precious | - | - | - | $218,408 | 1,003 | $47,566,524 | Nov 6 | Lionsgate Films | false |
| 34 | The Lovely Bones | - | - | - | $13,120 | 2,638 | $44,114,232 | Dec 11 | DreamWorks | false |
| 32 | Planet 51 | - | - | - | $20,007 | 3,035 | $42,194,060 | Nov 20 | Sony Pictures Releasing | false |
| 24 | Crazy Heart | - | - | - | $54,083 | 1,361 | $39,464,306 | Dec 16 | - | false |
| 23 | Ninja Assassin | - | - | - | $71,395 | 2,503 | $38,122,883 | Nov 25 | Warner Bros. | false |
| 10 | Invictus | - | - | - | $1,312,569 | 2,170 | $37,491,364 | Dec 11 | Warner Bros. | false |
| 40 | Under the Sea 3D | - | - | - | $1,789 | 108 | $36,262,926 | Feb 13 | Warner Bros. | false |
| 37 | The Men Who Stare at Goats | - | - | - | $6,723 | 2,453 | $32,428,195 | Nov 6 | Overture Films | false |
| 9 | Did You Hear About the Morgans? | - | - | - | $1,539,943 | 2,718 | $29,580,087 | Dec 18 | Sony Pictures Releasing | false |
| 14 | Brothers | - | - | - | $390,479 | 2,088 | $28,544,157 | Dec 4 | Lionsgate Films | false |
| 35 | The Fourth Kind | - | - | - | $12,160 | 2,530 | $25,486,040 | Nov 6 | Universal Pictures | false |
| 21 | Fantastic Mr. Fox | - | - | - | $96,438 | 2,304 | $21,002,919 | Nov 13 | Twentieth Century Fox | false |
| 7 | Nine | - | - | - | $2,030,047 | 1,412 | $19,676,965 | Dec 18 | The Weinstein Company | false |
| 36 | Astro Boy | - | - | - | $10,745 | 3,020 | $19,551,067 | Oct 23 | Summit Entertainment | false |
| 20 | Armored | - | - | - | $111,659 | 1,919 | $15,988,876 | Dec 4 | Screen Gems | false |
| 39 | The Box | - | - | - | $4,382 | 2,635 | $15,051,977 | Nov 6 | Warner Bros. | false |
| 42 | Amelia | - | - | - | $1,371 | 1,070 | $14,246,488 | Oct 23 | - | false |
| 18 | The Young Victoria | - | - | - | $165,482 | 476 | $11,001,272 | Dec 18 | Apparition | false |
| 29 | The Boondock Saints II: All Saints Day | - | - | - | $24,403 | 524 | $10,273,188 | Oct 30 | Apparition | false |
| 31 | A Serious Man | - | - | - | $21,371 | 262 | $9,228,768 | Oct 2 | Focus Features | false |
| 22 | A Single Man | - | - | - | $95,869 | 354 | $9,176,000 | Dec 11 | The Weinstein Company | false |
| 19 | The Road | - | - | - | $117,050 | 396 | $8,117,000 | Nov 25 | - | false |
| 38 | The Boat That Rocked | - | - | - | $6,413 | 883 | $8,017,917 | Nov 13 | Focus Features | false |
| 12 | 3 Idiots | - | - | - | $657,207 | 156 | $6,532,874 | Dec 23 | Reliance Big Pictures | false |
| 44 | The September Issue | - | - | - | $156 | 143 | $3,820,067 | Aug 28 | Roadside Attractions | false |
| 30 | Me and Orson Welles | - | - | - | $23,427 | 134 | $1,190,003 | Nov 25 | Freestyle Releasing | false |
| 43 | The Maid | - | - | - | $1,297 | 19 | $576,608 | Oct 16 | Elephant Eye Films | false |
| 41 | The Polar Express 2009 IMAX Release | - | - | - | $1,568 | 21 | $514,354 | Nov 6 | Warner Bros. | false |
| 46 | The Slammin' Salmon | - | - | - | $54 | 11 | $41,587 | Dec 11 | Anchor Bay Films | false |
| 45 | Oh My God | - | - | - | $134 | 7 | $38,244 | Nov 13 | Mitropoulos Films | false |
