| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | The Hangover Part II | $774,605 | 84 | $244,980 | 84 | May 26, 2011 | Warner Bros. |
| 2 | Neighbors | $443,244 | 51 | $185,844 | 51 | May 29, 2014 | Universal Pictures International (UPI) |
| 3 | 22 Jump Street | $424,116 | 57 | $157,513 | 57 | Sep 25, 2014 | Sony Pictures Releasing |
| 4 | The Hangover | $423,433 | 28 | $129,424 | 28 | Aug 20, 2009 | Warner Bros. |
| 5 | Bad Teacher | $393,665 | 39 | $113,853 | 39 | Sep 8, 2011 | Sony Pictures Releasing |
| 6 | 40 Days and 40 Nights | $324,067 | - | - | - | Aug 15, 2002 | - |
| 7 | Blockers | $298,053 | 85 | $157,915 | 85 | Apr 5, 2018 | United International Pictures |
| 8 | The 40-Year-Old Virgin | $280,994 | - | - | - | Nov 17, 2005 | - |
| 9 | Jackass Presents: Bad Grandpa | $260,747 | 27 | $64,722 | 27 | Nov 14, 2013 | Paramount Pictures International |
| 10 | Deuce Bigalow: European Gigolo | $241,334 | - | - | - | Oct 13, 2005 | - |
| 11 | Project X | $223,915 | 31 | $69,402 | 29 | Mar 8, 2012 | Warner Bros. |
| 12 | American Wedding | $212,955 | - | - | - | Dec 11, 2003 | - |
| 13 | Knocked Up | $206,719 | 25 | - | - | Oct 25, 2007 | - |
| 14 | The Girl Next Door | $184,859 | - | - | - | Jun 24, 2004 | - |
| 15 | Forgetting Sarah Marshall | $171,334 | 21 | $72,298 | 21 | Nov 20, 2008 | - |
| 16 | 21 & Over | $170,534 | 35 | $63,166 | 35 | Oct 3, 2013 | - |
| 17 | Superbad | $170,139 | 15 | - | - | Nov 29, 2007 | - |
| 18 | Wedding Crashers | $161,233 | - | - | - | Nov 10, 2005 | - |
| 19 | 21 Jump Street | $148,495 | 25 | $61,474 | 25 | Jun 7, 2012 | Sony Pictures Releasing |
| 20 | Bridesmaids | $136,609 | 30 | $60,034 | 30 | Oct 6, 2011 | Universal Pictures International (UPI) |
| 21 | Jackass 3D | $86,943 | 10 | $57,260 | 10 | Nov 11, 2010 | Paramount Pictures International |
| 22 | Role Models | $86,456 | 24 | $38,521 | 24 | Apr 16, 2009 | Universal Pictures International (UPI) |
| 23 | Sex Drive | $78,841 | 22 | $46,429 | 22 | Jun 4, 2009 | - |
| 24 | Old School | $47,839 | - | - | - | Sep 4, 2003 | - |
| 25 | Youth in Revolt | $43,073 | 12 | $23,344 | 12 | Dec 16, 2010 | - |
| 26 | Pineapple Express | $28,381 | 10 | $11,109 | 10 | Sep 25, 2008 | - |
| 27 | Good Boys | $27,450 | 40 | $24,380 | 40 | Oct 24, 2019 | United International Pictures |
