| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | The Hangover Part II | $13,505,147 | 576 | $3,145,311 | 570 | May 27, 2011 | Warner Bros. |
| 2 | Unfaithful | $9,860,168 | 314 | - | - | Dec 20, 2002 | - |
| 3 | American Wedding | $6,541,377 | 367 | - | - | Oct 3, 2003 | - |
| 4 | The 40-Year-Old Virgin | $6,116,775 | 231 | $1,775,807 | 196 | Jan 13, 2006 | United International Pictures |
| 5 | The Hangover | $5,950,032 | 292 | $891,619 | 292 | Jun 19, 2009 | Warner Bros. |
| 6 | In the Cut | $5,886,478 | 93 | - | - | Dec 19, 2003 | - |
| 7 | Twisted | $3,680,495 | 253 | $1,305,661 | 253 | Nov 26, 2004 | Eagle Pictures |
| 8 | Basic Instinct 2 | $3,178,196 | 384 | $1,367,138 | 384 | Mar 31, 2006 | Warner Bros. |
| 9 | Bad Teacher | $2,777,525 | 272 | $1,040,009 | 272 | Aug 31, 2011 | Sony Pictures Releasing |
| 10 | Knocked Up | $2,675,757 | 255 | $936,668 | 255 | Oct 19, 2007 | Universal Pictures International (UPI) |
| 11 | Wedding Crashers | $2,550,388 | 318 | $787,532 | 318 | Sep 9, 2005 | Eagle Pictures |
| 12 | 40 Days and 40 Nights | $2,533,586 | 180 | - | - | May 10, 2002 | - |
| 13 | Van Wilder | $2,424,221 | 282 | - | - | Apr 25, 2003 | - |
| 14 | Perfect Stranger | $2,273,376 | 285 | $977,655 | 285 | Apr 13, 2007 | Sony Pictures Releasing |
| 15 | Jackass 3D | $2,122,575 | 189 | $710,245 | 180 | Dec 3, 2010 | Universal Pictures International (UPI) |
| 16 | Birthday Girl | $1,967,637 | 239 | - | - | Jan 25, 2002 | - |
| 17 | Sex Drive | $1,951,363 | 151 | $358,412 | 151 | Aug 14, 2009 | Eagle Pictures |
| 18 | Femme Fatale | $1,883,413 | 192 | - | - | Nov 22, 2002 | - |
| 19 | Bridesmaids | $1,842,301 | 275 | $419,745 | 249 | Aug 19, 2011 | United International Pictures |
| 20 | Project X | $1,484,339 | 280 | $506,115 | 280 | Jun 6, 2012 | Warner Bros. |
| 21 | The Inbetweeners | $1,406,844 | 137 | - | - | Dec 23, 2011 | Eagle Pictures |
| 22 | Neighbors | $1,089,062 | 235 | $466,038 | 235 | Aug 20, 2014 | United International Pictures |
| 23 | Superbad | $889,369 | 221 | $451,859 | 221 | Sep 21, 2007 | Sony Pictures Releasing |
| 24 | The Boy Next Door | $738,410 | - | $268,619 | - | Jul 23, 2015 | - |
| 25 | 22 Jump Street | $723,304 | 124 | $237,806 | 124 | Jul 23, 2014 | - |
| 26 | Deception | $664,207 | 208 | $298,157 | 208 | Aug 29, 2008 | Mikado Film |
| 27 | 21 & Over | $583,612 | 84 | $324,427 | 84 | Jan 9, 2014 | - |
| 28 | The Girl Next Door | $571,201 | 68 | $242,714 | 68 | Dec 3, 2004 | 20th Century Fox International |
| 29 | Deuce Bigalow: European Gigolo | $502,296 | 101 | $211,643 | 101 | Aug 26, 2005 | Sony Pictures Releasing |
| 30 | Chloe | $416,579 | 87 | $205,460 | 87 | Mar 12, 2010 | Eagle Pictures |
| 31 | Harold & Kumar Go to White Castle | $380,841 | 68 | $146,707 | 68 | Apr 22, 2005 | CDI Films |
| 32 | Booksmart | $373,936 | 239 | $188,270 | 239 | Aug 21, 2019 | Eagle Pictures |
| 33 | She's Out of My League | $308,584 | 60 | $130,794 | 60 | Jun 18, 2010 | United International Pictures |
| 34 | Take Me Home Tonight | $286,932 | 104 | $154,437 | 104 | Mar 23, 2012 | United International Pictures |
| 35 | Forgetting Sarah Marshall | $151,549 | 100 | $73,175 | 100 | Aug 22, 2008 | United International Pictures |
| 36 | 3-D Sex and Zen: Extreme Ecstasy | $147,219 | 132 | $83,995 | 132 | Sep 30, 2011 | Moviemax |
| 37 | The Canyons | $133,644 | 126 | $133,644 | 126 | Nov 14, 2013 | - |
| 38 | The Housemaid | $129,421 | 59 | $48,899 | 59 | May 27, 2011 | Fandango |
| 39 | Swimming Pool | $100,820 | 25 | - | - | Oct 31, 2003 | - |
| 40 | Nathalie... | $92,531 | 54 | $92,531 | 54 | Oct 15, 2004 | Istituto Luce |
| 41 | I Love You, Man | $86,204 | 49 | $42,059 | 49 | Aug 21, 2009 | United International Pictures |
| 42 | Obsessed | $83,546 | 12 | $19,433 | 12 | Jul 17, 2009 | Sony Pictures Releasing |
| 43 | The Handmaiden | $74,320 | 16 | $26,055 | 16 | Aug 29, 2019 | Altre Storie |
| 44 | Blockers | $70,851 | 105 | $45,999 | 105 | May 17, 2018 | Universal Pictures International (UPI) |
| 45 | 21 Jump Street | $62,751 | 33 | $23,146 | 31 | Jun 15, 2012 | Warner Bros. |
| 46 | Good Boys | $34,311 | 106 | $34,311 | 106 | Sep 12, 2019 | Universal Pictures International (UPI) |
| 47 | Adventureland | $31,944 | 15 | $7,618 | 15 | Jul 10, 2009 | Walt Disney Pictures |
| 48 | Role Models | $23,593 | 99 | $23,593 | 99 | May 22, 2009 | United International Pictures |
| 49 | Grandma's Boy | $23,250 | - | - | - | Aug 4, 2006 | - |
| 50 | Ghost World | $20,206 | 6 | - | - | Nov 8, 2002 | - |
| 51 | Pineapple Express | $15,084 | 11 | $11,136 | 11 | Nov 28, 2008 | Sony Pictures Releasing |
| 52 | Jay and Silent Bob Strike Back | $10,843 | 19 | - | - | Jun 14, 2002 | - |
| 53 | EuroTrip | $8,592 | - | - | - | Aug 6, 2004 | - |
| 54 | National Lampoon's Animal House | $7,219 | 38 | $7,219 | 38 | Jun 8, 2023 | - |
| 55 | Old School | $1,056 | - | - | - | Aug 8, 2003 | - |
