| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | Ted | $218,815,487 | 3,303 | $54,415,205 | 3,239 | Jun 29, 2012 | Universal Pictures |
| 2 | The Heat | $159,582,188 | 3,184 | $39,115,043 | 3,181 | Jun 28, 2013 | Twentieth Century Fox |
| 3 | Good Will Hunting | $138,433,435 | 2,203 | $272,912 | 7 | Dec 5, 1997 | Miramax |
| 4 | The Departed | $132,384,315 | 3,017 | $26,887,467 | 3,017 | Oct 6, 2006 | Warner Bros. |
| 5 | Legally Blonde | $96,520,674 | 2,725 | $20,377,426 | 2,620 | Jul 13, 2001 | Metro-Goldwyn-Mayer (MGM) |
| 6 | The Town | $92,186,262 | 2,935 | $23,808,032 | 2,861 | Sep 17, 2010 | Warner Bros. |
| 7 | Mystic River | $90,135,191 | 1,581 | $640,815 | 13 | Oct 8, 2003 | Warner Bros. |
| 8 | Black Mass | $62,575,678 | 3,188 | $22,635,037 | 3,188 | Sep 18, 2015 | Warner Bros. |
| 9 | The Verdict | $53,977,250 | 904 | $100,982 | 3 | Dec 10, 1982 | Twentieth Century Fox |
| 10 | Spotlight | $45,055,776 | 1,227 | $295,009 | 5 | Nov 6, 2015 | Open Road Films (II) |
| 11 | Fever Pitch | $42,071,069 | 3,275 | $12,400,125 | 3,267 | Apr 8, 2005 | Twentieth Century Fox |
| 12 | Patriots Day | $31,886,361 | 3,120 | $161,306 | 7 | Dec 21, 2016 | Lionsgate Films |
| 13 | How High | $31,178,740 | 1,273 | $7,102,260 | 1,266 | Dec 21, 2001 | Universal Pictures |
| 14 | Blown Away | $30,156,002 | 1,862 | $10,424,873 | 1,862 | Jul 1, 1994 | Metro-Goldwyn-Mayer (MGM) |
| 15 | Soul Man | $27,820,000 | 1,320 | $4,422,179 | 1,282 | Oct 24, 1986 | New World Pictures |
| 16 | Gone Baby Gone | $20,300,218 | 1,713 | $2,299,000 | 1,713 | Oct 19, 2007 | Miramax |
| 17 | Two If by Sea | $10,658,278 | 1,796 | $4,656,986 | 1,712 | Jan 12, 1996 | Warner Bros. |
| 18 | Celtic Pride | $9,255,027 | 1,836 | $3,809,248 | 1,832 | Apr 19, 1996 | Walt Disney Studios Motion Pictures |
| 19 | Next Stop Wonderland | $3,395,581 | 224 | $123,055 | 8 | Aug 21, 1998 | Miramax |
| 20 | Still We Believe: The Boston Red Sox Movie | $396,803 | 54 | $91,388 | 17 | May 7, 2004 | THINKFilm |
| 21 | Monument Ave. | $333,760 | 24 | $41,556 | 10 | Sep 25, 1998 | Lionsgate Films |
| 22 | Harvard Man | $56,653 | 4 | $8,425 | 1 | May 17, 2002 | Cowboy Pictures |
| 23 | Southie | $52,819 | 2 | $16,860 | 2 | May 28, 1999 | Lionsgate Films |
| 24 | The Boondock Saints | $30,471 | 5 | $19,930 | 5 | Jan 21, 2000 | Indican Pictures |
| 25 | On Broadway | $23,968 | 5 | $8,268 | 5 | Mar 14, 2008 | - |
