| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | Alvin and the Chipmunks: The Road Chip | $6,807,266 | 395 | $1,809,430 | 351 | Dec 23, 2015 | 20th Century Fox International |
| 2 | We're the Millers | $5,806,736 | 318 | $1,586,661 | 303 | Sep 12, 2013 | Warner Bros. |
| 3 | Due Date | $5,406,458 | 272 | $1,999,103 | 272 | Jan 28, 2011 | Warner Bros. |
| 4 | About Schmidt | $4,648,502 | 213 | - | - | Feb 7, 2003 | - |
| 5 | Wild Hogs | $4,024,291 | 292 | $1,243,158 | 292 | Apr 20, 2007 | Buena Vista International |
| 6 | Vacation | $3,123,973 | - | $1,009,569 | - | Aug 12, 2015 | - |
| 7 | Dumb and Dumber To | $3,122,098 | - | $1,677,162 | - | Dec 4, 2014 | - |
| 8 | Sideways | $2,999,173 | 164 | $609,824 | 164 | Feb 18, 2005 | 20th Century Fox International |
| 9 | Broken Flowers | $2,629,203 | 129 | $446,677 | 86 | Dec 2, 2005 | Mikado Film |
| 10 | Little Miss Sunshine | $2,039,673 | 68 | $164,606 | 68 | Sep 22, 2006 | 20th Century Fox International |
| 11 | Sex Drive | $1,951,363 | 151 | $358,412 | 151 | Aug 14, 2009 | Eagle Pictures |
| 12 | Rat Race | $1,418,911 | 224 | - | - | Jan 11, 2002 | - |
| 13 | Transamerica | $1,232,815 | 52 | $109,187 | 20 | Feb 10, 2006 | DNC Entertainment |
| 14 | Nebraska | $1,138,757 | 83 | $375,941 | 81 | Jan 16, 2014 | Lucky Red |
| 15 | Harold & Kumar Go to White Castle | $380,841 | 68 | $146,707 | 68 | Apr 22, 2005 | CDI Films |
| 16 | RV | $347,517 | 92 | $212,693 | 92 | Jun 1, 2006 | Sony Pictures Releasing |
| 17 | Seeking a Friend for the End of the World | $287,836 | 90 | $125,439 | 90 | Jan 17, 2013 | M2 Pictures |
| 18 | Identity Thief | $130,165 | 118 | $62,310 | 118 | Aug 8, 2013 | United International Pictures |
| 19 | Are We There Yet? | $16,660 | - | - | - | Mar 4, 2005 | - |
| 20 | Jay and Silent Bob Strike Back | $10,843 | 19 | - | - | Jun 14, 2002 | - |
| 21 | EuroTrip | $8,592 | - | - | - | Aug 6, 2004 | - |
| 22 | College Road Trip | $7,722 | 15 | $7,722 | 15 | Jul 18, 2008 | Walt Disney Pictures |
