| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | Inside Out | $356,461,711 | 4,158 | $90,440,272 | 3,946 | Jun 19, 2015 | Walt Disney Studios Motion Pictures |
| 2 | Inception | $292,576,195 | 3,792 | $62,785,337 | 3,792 | Jul 16, 2010 | Warner Bros. |
| 3 | Shutter Island | $128,012,934 | 3,356 | $41,062,440 | 2,991 | Feb 19, 2010 | Paramount Pictures |
| 4 | Vanilla Sky | $100,618,344 | 2,842 | $25,015,518 | 2,742 | Dec 14, 2001 | Paramount Pictures |
| 5 | The Forgotten | $67,133,509 | 3,144 | $21,022,111 | 3,104 | Sep 24, 2004 | Revolution Studios |
| 6 | Looper | $66,486,205 | 2,993 | $20,801,552 | 2,992 | Sep 28, 2012 | TriStar Pictures |
| 7 | The Cell | $61,334,059 | 2,476 | $17,515,050 | 2,411 | Aug 18, 2000 | New Line Cinema |
| 8 | 12 Monkeys | $57,141,459 | 1,629 | $184,776 | 3 | Dec 29, 1995 | Universal Pictures |
| 9 | What Dreams May Come | $55,382,927 | 2,531 | $15,833,592 | 2,526 | Oct 2, 1998 | PolyGram |
| 10 | Source Code | $54,712,227 | 2,971 | $14,812,094 | 2,961 | Apr 1, 2011 | Summit Entertainment |
| 11 | Fight Club | $37,030,102 | 1,966 | $11,035,485 | 1,963 | Oct 15, 1999 | Twentieth Century Fox |
| 12 | Jacob's Ladder | $26,118,851 | 1,264 | $7,500,760 | 1,052 | Nov 2, 1990 | TriStar Pictures |
| 13 | Memento | $25,544,867 | 531 | $235,488 | 11 | Mar 16, 2001 | Newmarket Films |
| 14 | Transcendence | $23,022,309 | 3,455 | $10,886,386 | 3,455 | Apr 18, 2014 | Warner Bros. |
| 15 | Altered States | $19,853,892 | 3 | $174,650 | 3 | Dec 25, 1980 | Warner Bros. |
| 16 | Dreamscape | $12,145,169 | 816 | $2,257,627 | 816 | Aug 17, 1984 | Twentieth Century Fox |
| 17 | The Imaginarium of Doctor Parnassus | $7,689,607 | 607 | $415,233 | 48 | Dec 25, 2009 | Sony Pictures Classics |
| 18 | Mulholland Drive | $7,220,243 | 247 | $587,591 | 66 | Oct 8, 2001 | Universal Pictures |
| 19 | Lost Highway | $3,675,201 | 337 | $212,710 | 12 | Feb 21, 1997 | October Films |
| 20 | eXistenZ | $2,856,712 | 256 | $810,262 | 256 | Apr 23, 1999 | Miramax |
| 21 | Trance | $2,328,743 | 443 | $131,145 | 4 | Apr 5, 2013 | - |
| 22 | Donnie Darko | $753,147 | 22 | $24,728 | 7 | Jun 2, 2004 | Newmarket Films |
| 23 | Upstream Color | $444,098 | 43 | $28,649 | 1 | Apr 5, 2013 | - |
| 24 | Open Your Eyes | $370,720 | 34 | $38,289 | 10 | Apr 16, 1999 | Artisan Entertainment |
| 25 | Coherence | $102,617 | 7 | $17,000 | 2 | Jun 20, 2014 | Oscilloscope |
