| Rank
| Title
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
|
|---|
| 1 | A Dog's Purpose | $2,425,772 | 89 | $483,135 | 89 | Jan 26, 2017 | Universal Pictures International (UPI) |
| 2 | Cats & Dogs: The Revenge of Kitty Galore | $1,304,761 | 66 | $466,178 | 66 | Aug 12, 2010 | Warner Bros. |
| 3 | A Dog's Way Home | $1,153,981 | 110 | $308,599 | 110 | Jan 24, 2019 | Sony Pictures Releasing |
| 4 | A Dog's Journey | $934,593 | 98 | $443,550 | 98 | May 16, 2019 | United International Pictures |
| 5 | Hotel for Dogs | $694,624 | 30 | $205,192 | 30 | Jan 22, 2009 | - |
| 6 | Marmaduke | $685,981 | 35 | $237,504 | 35 | Jun 3, 2010 | 20th Century Fox International |
| 7 | Alpha | $674,813 | 99 | $266,484 | 99 | Sep 13, 2018 | Sony Pictures Releasing |
| 8 | Beverly Hills Chihuahua | $544,202 | 35 | $163,692 | 35 | Nov 13, 2008 | - |
| 9 | Underdog | $516,994 | 23 | $85,627 | 23 | Sep 20, 2007 | - |
| 10 | Marley & Me | $433,875 | 21 | $132,058 | 21 | Jan 8, 2009 | - |
| 11 | Scooby-Doo 2: Monsters Unleashed | $349,077 | - | - | - | Apr 1, 2004 | - |
| 12 | The Call of the Wild | $335,068 | 50 | $101,590 | 50 | Feb 20, 2020 | - |
| 13 | John Wick | $268,928 | 57 | $133,939 | 57 | Dec 25, 2014 | Andes Films |
| 14 | Firehouse Dog | $182,108 | 22 | $36,431 | 22 | Oct 4, 2007 | - |
| 15 | Clifford the Big Red Dog | $175,325 | - | - | - | Dec 9, 2021 | Paramount Pictures |
| 16 | Seven Psychopaths | $146,204 | 28 | $69,879 | 28 | Mar 14, 2013 | - |
| 17 | Lassie | $143,945 | 14 | $40,898 | 14 | Sep 11, 2008 | - |
