| Rank
| Release
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
| Estimated
|
|---|
| 1 | Deadpool | $363,070,709 | 3,856 | $132,434,639 | 3,558 | Feb 12, 2016 | 20th Century Fox | false |
| 2 | Deadpool 2 | $318,491,426 | 4,349 | $125,507,153 | 4,349 | May 18, 2018 | 20th Century Fox | false |
| 3 | X-Men: The Last Stand | $234,362,462 | 3,714 | $102,750,665 | 3,690 | May 26, 2006 | 20th Century Fox | false |
| 4 | X-Men: Days of Future Past | $233,921,534 | 4,001 | $90,823,660 | 3,996 | May 23, 2014 | 20th Century Fox | false |
| 5 | Logan | $226,277,068 | 4,071 | $88,411,916 | 4,071 | Mar 3, 2017 | 20th Century Fox | false |
| 6 | X2: X-Men United | $214,949,694 | 3,749 | $85,558,731 | 3,741 | May 2, 2003 | 20th Century Fox | false |
| 7 | X-Men Origins: Wolverine | $179,883,157 | 4,102 | $85,058,003 | 4,099 | May 1, 2009 | 20th Century Fox | false |
| 8 | X-Men | $157,299,718 | 3,112 | $54,471,475 | 3,025 | Jul 14, 2000 | 20th Century Fox | false |
| 9 | X-Men: Apocalypse | $155,442,489 | 4,153 | $65,769,562 | 4,150 | May 27, 2016 | 20th Century Fox | false |
| 10 | X-Men: First Class | $146,408,305 | 3,692 | $55,101,604 | 3,641 | Jun 3, 2011 | 20th Century Fox | false |
| 11 | The Wolverine | $132,556,852 | 3,924 | $53,113,752 | 3,924 | Jul 26, 2013 | 20th Century Fox | false |
| 12 | X-Men: Dark Phoenix | $65,845,974 | 3,721 | $32,828,348 | 3,721 | Jun 7, 2019 | 20th Century Fox | false |
| 13 | The New Mutants | $23,852,659 | 2,754 | $7,037,017 | 2,412 | Aug 28, 2020 | 20th Century Studios | false |
| 14 | Once Upon a Deadpool 2018 Re-release | $6,100,309 | 1,566 | $2,683,200 | 1,566 | Dec 12, 2018 | 20th Century Fox | false |
