| Rank
| Release
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
| Estimated
|
|---|
| 1 | Resident Evil: Afterlife | $60,128,566 | 3,209 | $26,650,264 | 3,203 | Sep 10, 2010 | Screen Gems | false |
| 2 | Resident Evil: Apocalypse | $51,201,453 | 3,284 | $23,036,273 | 3,284 | Sep 10, 2004 | Screen Gems | false |
| 3 | Resident Evil: Extinction | $50,648,679 | 2,848 | $23,678,580 | 2,828 | Sep 21, 2007 | Screen Gems | false |
| 4 | Resident Evil: Retribution | $42,345,531 | 3,016 | $21,052,227 | 3,012 | Sep 14, 2012 | Screen Gems | false |
| 5 | Resident Evil | $40,119,709 | 2,528 | $17,707,106 | 2,528 | Mar 15, 2002 | Screen Gems | false |
| 6 | Resident Evil: The Final Chapter | $26,830,068 | 3,104 | $13,601,682 | 3,104 | Jan 27, 2017 | Screen Gems | false |
