| TD | YD | Release
| Distributor
| Daily | %± YD | %± LW | Theaters | Avg | To Date | Days | New This Day
| Estimated
|
|---|
| 1 | 1 | Shutter Island | Paramount Pictures | $10,703,887 | -34.3% | - | 2,991 | $3,578 | $41,062,440 | 3 | - | false |
| 2 | 2 | Avatar | Twentieth Century Fox | $4,890,260 | -34.4% | -50.5% | 2,581 | $1,894 | $687,962,011 | 66 | - | false |
| 3 | 4 | Percy Jackson & the Olympians: The Lightning Thief | Twentieth Century Fox | $4,248,196 | -39.1% | -58.2% | 3,396 | $1,250 | $58,714,813 | 10 | - | false |
| 4 | 3 | Valentine's Day | Warner Bros. | $3,667,737 | -50% | -84.3% | 3,665 | $1,000 | $86,927,385 | 10 | - | false |
| 5 | 5 | The Wolfman | Universal Pictures | $2,723,435 | -36.5% | -75.5% | 3,223 | $845 | $50,363,730 | 10 | - | false |
| 6 | 6 | Dear John | Screen Gems | $1,623,556 | -48.5% | -75.1% | 3,062 | $530 | $65,801,765 | 17 | - | false |
| 7 | 7 | Tooth Fairy | Twentieth Century Fox | $1,235,963 | -40% | -49.4% | 2,523 | $489 | $49,721,400 | 31 | - | false |
| 8 | 8 | Crazy Heart | Fox Searchlight Pictures | $810,919 | -41.8% | -52.1% | 1,089 | $744 | $21,524,784 | 68 | - | false |
| 9 | 9 | From Paris with Love | Lionsgate | $750,143 | -36.7% | -67.8% | 2,311 | $324 | $21,361,504 | 17 | - | false |
| 10 | 10 | Edge of Darkness | Warner Bros. | $570,502 | -45.9% | -70.5% | 2,118 | $269 | $40,347,222 | 24 | - | false |
| 11 | 11 | The Book of Eli | Warner Bros. | $504,849 | -41.6% | -67.8% | 1,455 | $346 | $90,775,391 | 38 | - | false |
| 12 | 12 | When in Rome | Walt Disney Studios Motion Pictures | $392,091 | -50.9% | -75.3% | 1,627 | $240 | $29,344,987 | 24 | - | false |
| 13 | 13 | The Blind Side | Warner Bros. | $347,403 | -51.1% | -60.3% | 1,060 | $327 | $247,071,052 | 94 | - | false |
| 14 | 15 | Alvin and the Chipmunks: The Squeakquel | Twentieth Century Fox | $290,873 | -35.5% | -46.2% | 841 | $345 | $215,581,073 | 61 | - | false |
| 15 | 14 | Up in the Air | Paramount Pictures | $266,078 | -48% | -61.9% | 727 | $365 | $80,908,880 | 80 | - | false |
| 16 | 16 | Sherlock Holmes | Warner Bros. | $200,285 | -51.4% | -68.4% | 713 | $280 | $205,534,198 | 59 | - | false |
| 17 | 18 | My Name Is Khan | Fox Searchlight Pictures | $194,863 | -39.1% | -74.5% | 125 | $1,558 | $3,253,168 | 10 | - | false |
| 18 | 19 | Legion | Screen Gems | $170,835 | -39.1% | -80.2% | 786 | $217 | $39,221,554 | 31 | - | false |
| 19 | 17 | It's Complicated | Universal Pictures | $170,305 | -49.6% | -64.2% | 598 | $284 | $110,724,780 | 59 | - | false |
| 20 | 20 | The Twilight Saga: New Moon | Summit Entertainment | $104,333 | -39.3% | -51.6% | 325 | $321 | $295,598,642 | 94 | - | false |
| 21 | 21 | A Single Man | The Weinstein Company | $98,256 | -37.7% | -44.1% | 255 | $385 | $7,506,512 | 73 | - | false |
| 22 | 23 | The Spy Next Door | Lionsgate | $83,471 | -29.3% | -56.1% | 215 | $388 | $24,026,111 | 38 | - | false |
| 23 | 24 | The Young Victoria | Apparition | $75,656 | -31.2% | -31.5% | 219 | $345 | $9,841,072 | 66 | - | false |
| 24 | 22 | The Lovely Bones | DreamWorks | $67,691 | -44% | -77.2% | 469 | $144 | $43,364,519 | 73 | - | false |
| 25 | 27 | The Ghost Writer | Summit Entertainment | $64,300 | -8.2% | - | 4 | $16,075 | $183,009 | 3 | - | false |
| 26 | 25 | Planet 51 | Sony Pictures Releasing | $56,935 | -31.5% | -28.3% | 206 | $276 | $41,802,947 | 94 | - | false |
| 27 | 26 | Precious | Lionsgate | $48,006 | -33.7% | -40.5% | 259 | $185 | $46,819,335 | 108 | - | false |
| 28 | 28 | Under the Sea 3D | Warner Bros. | $33,655 | -35.6% | -34.1% | 29 | $1,160 | $20,439,008 | 374 | - | false |
| 29 | 31 | 2012 | Sony Pictures Releasing | $23,176 | -38.9% | -56.1% | 131 | $176 | $166,112,167 | 101 | - | false |
| 30 | 29 | Leap Year | Universal Pictures | $22,440 | -55.6% | -55.6% | 187 | $120 | $25,789,265 | 45 | - | false |
| 31 | 30 | Invictus | Warner Bros. | $20,867 | -47.2% | -50.5% | 101 | $206 | $36,920,118 | 73 | - | false |
| 32 | 32 | Fantastic Mr. Fox | Twentieth Century Fox | $19,723 | -22.2% | -49.7% | 75 | $262 | $20,760,922 | 101 | - | false |
| 33 | 33 | The Road | - | $17,286 | -25.2% | +147.3% | 111 | $155 | $8,025,059 | 89 | - | false |
| 34 | 34 | The Good Guy | Roadside Attractions | $10,030 | -30.8% | - | 9 | $1,114 | $34,712 | 3 | - | false |
| 35 | 36 | Nine | The Weinstein Company | $6,191 | -31.3% | -62.7% | 50 | $123 | $19,574,921 | 66 | - | false |
| 36 | 35 | Youth in Revolt | - | $5,665 | -38.1% | -56% | 32 | $177 | $15,180,449 | 45 | - | false |
| 37 | 37 | 3 Idiots | Reliance Big Pictures | $4,098 | -41.9% | -62.3% | 22 | $186 | $6,523,103 | 61 | - | false |
| 38 | 38 | Happy Tears | Roadside Attractions | $3,682 | -36.8% | - | 15 | $245 | $13,009 | 3 | - | false |
| 39 | 41 | Frozen | Anchor Bay Films | $1,859 | -32.4% | -72.3% | 8 | $232 | $218,902 | 17 | - | false |
| 40 | 40 | That Evening Sun | Freestyle Releasing | $1,601 | -49.2% | -63.9% | 6 | $266 | $166,191 | 108 | - | false |
| 41 | 39 | Me and Orson Welles | Freestyle Releasing | $1,465 | -59% | -77.3% | 9 | $162 | $1,186,957 | 89 | - | false |
| 42 | 44 | The Maid | Elephant Eye Films | $1,086 | +95.3% | +158% | 5 | $217 | $555,841 | 129 | - | false |
| 43 | 43 | The Cove | Roadside Attractions | $561 | -33.5% | +105.5% | 8 | $70 | $852,131 | 206 | - | false |
| 44 | 42 | Good Hair | Roadside Attractions | $332 | -77.7% | +46.3% | 3 | $110 | $4,156,426 | 136 | - | false |
| 45 | 45 | Mystery Team | Roadside Attractions | $278 | +44.8% | - | 1 | $278 | $73,138 | 178 | - | false |
