| TD | YD | Release
| Distributor
| Daily | %± YD | %± LW | Theaters | Avg | To Date | Days | New This Day
| Estimated
|
|---|
| 1 | 1 | Avatar | Twentieth Century Fox | $15,756,027 | -25.9% | -9.3% | 3,422 | $4,604 | $430,846,514 | 24 | - | false |
| 2 | 2 | Alvin and the Chipmunks: The Squeakquel | Twentieth Century Fox | $5,048,005 | -37.3% | -35.4% | 3,641 | $1,386 | $178,451,165 | 19 | - | false |
| 3 | 3 | Sherlock Holmes | Warner Bros. | $4,178,967 | -43% | -43.1% | 3,626 | $1,152 | $165,153,093 | 17 | - | false |
| 4 | 4 | Daybreakers | Lionsgate | $3,632,236 | -35.4% | - | 2,523 | $1,439 | $15,146,692 | 3 | - | false |
| 5 | 5 | It's Complicated | Universal Pictures | $2,895,900 | -40.6% | -27.3% | 2,955 | $980 | $76,370,540 | 17 | - | false |
| 6 | 6 | Leap Year | Universal Pictures | $2,046,465 | -46.9% | - | 2,511 | $815 | $9,202,815 | 3 | - | false |
| 7 | 7 | The Blind Side | Warner Bros. | $1,859,475 | -46.1% | -21.2% | 2,880 | $645 | $218,978,376 | 52 | - | false |
| 8 | 8 | Up in the Air | Paramount Pictures | $1,853,483 | -42.5% | -13.8% | 2,218 | $835 | $54,801,035 | 38 | - | false |
| 9 | 9 | Youth in Revolt | - | $1,664,553 | -33.6% | - | 1,873 | $888 | $6,888,334 | 3 | - | false |
| 10 | 10 | The Princess and the Frog | Walt Disney Studios Motion Pictures | $1,463,720 | -34.7% | -35.4% | 2,620 | $558 | $92,546,727 | 47 | - | false |
| 11 | 12 | The Twilight Saga: New Moon | Summit Entertainment | $465,416 | -38.5% | -39.9% | 1,167 | $398 | $290,743,279 | 52 | - | false |
| 12 | 14 | Nine | The Weinstein Company | $461,966 | -32.2% | -47.7% | 1,060 | $435 | $16,837,007 | 24 | - | false |
| 13 | 11 | Invictus | Warner Bros. | $445,373 | -42.7% | -43.8% | 1,340 | $332 | $33,506,889 | 31 | - | false |
| 14 | 13 | Did You Hear About the Morgans? | Sony Pictures Releasing | $375,808 | -44.9% | -61.7% | 1,820 | $206 | $28,346,423 | 24 | - | false |
| 15 | 15 | The Young Victoria | Apparition | $362,072 | -30% | - | 476 | $760 | $4,588,617 | 24 | - | false |
| 16 | 16 | 3 Idiots | Reliance Big Pictures | $188,149 | -31% | -40% | 156 | $1,206 | $5,604,042 | 19 | - | false |
| 17 | 18 | Precious | Lionsgate | $141,764 | -28.9% | -31.4% | 408 | $347 | $44,311,459 | 66 | - | false |
| 18 | 17 | Crazy Heart | Fox Searchlight Pictures | $141,133 | -29.4% | +185.5% | 33 | $4,276 | $1,246,747 | 26 | - | false |
| 19 | 20 | A Single Man | The Weinstein Company | $113,191 | -28.1% | -5.3% | 48 | $2,358 | $2,286,364 | 31 | - | false |
| 20 | 19 | 2012 | Sony Pictures Releasing | $103,514 | -38.1% | -52.7% | 351 | $294 | $164,105,051 | 59 | - | false |
| 21 | 21 | Brothers | Lionsgate | $98,486 | -35.4% | -59.9% | 428 | $230 | $28,198,793 | 38 | - | false |
| 22 | 22 | Fantastic Mr. Fox | Twentieth Century Fox | $86,671 | -32.4% | -24.2% | 265 | $327 | $19,559,123 | 59 | - | false |
| 23 | 23 | The Road | - | $74,378 | -30.6% | -40.4% | 207 | $359 | $7,361,887 | 47 | - | false |
| 24 | 24 | Cloudy with a Chance of Meatballs | Sony Pictures Releasing | $56,019 | -41.3% | -26.2% | 222 | $252 | $124,542,775 | 115 | - | false |
| 25 | 25 | Where the Wild Things Are | Warner Bros. | $52,372 | -32.9% | -15.9% | 243 | $215 | $76,826,594 | 87 | - | false |
| 26 | 26 | Couples Retreat | Universal Pictures | $35,460 | -47.1% | -15.9% | 197 | $180 | $108,731,660 | 94 | - | false |
| 27 | 27 | The Men Who Stare at Goats | Overture Films | $32,806 | -36.8% | +259.6% | 198 | $165 | $32,158,526 | 66 | - | false |
| 28 | 28 | Law Abiding Citizen | Overture Films | $29,861 | -36.6% | -13.2% | 194 | $153 | $73,106,880 | 87 | - | false |
| 29 | 30 | Planet 51 | Sony Pictures Releasing | $26,055 | -33.9% | -31.8% | 132 | $197 | $39,688,154 | 52 | - | false |
| 30 | 29 | Armored | Screen Gems | $24,669 | -46.2% | -57.5% | 118 | $209 | $15,988,876 | 38 | - | false |
| 31 | 32 | Under the Sea 3D | Warner Bros. | $19,880 | -30.9% | +20.5% | 28 | $710 | $19,509,797 | 332 | - | false |
| 32 | 31 | Ninja Assassin | Warner Bros. | $19,808 | -32.2% | -47.2% | 101 | $196 | $37,627,463 | 47 | - | false |
| 33 | 34 | The Boondock Saints II: All Saints Day | Apparition | $16,013 | -33.6% | -44.7% | 62 | $258 | $10,082,650 | 73 | - | false |
| 34 | 33 | Crazy on the Outside | Freestyle Releasing | $15,926 | -42.6% | - | 75 | $212 | $64,438 | 3 | - | false |
| 35 | 35 | Astro Boy | Summit Entertainment | $14,589 | -30.7% | -8% | 106 | $137 | $19,515,628 | 80 | - | false |
| 36 | 37 | The Lovely Bones | DreamWorks | $13,706 | -10.4% | -14.5% | 3 | $4,568 | $448,080 | 31 | - | false |
| 37 | 36 | Me and Orson Welles | Freestyle Releasing | $10,102 | -37.1% | -55.6% | 35 | $288 | $1,021,113 | 47 | - | false |
| 38 | 38 | Paranormal Activity | Paramount Pictures | $7,018 | -43.6% | -44.4% | 103 | $68 | $107,901,736 | 108 | - | false |
| 39 | 41 | The Maid | Elephant Eye Films | $3,331 | -10.1% | +80.4% | 11 | $302 | $505,181 | 87 | - | false |
| 40 | 40 | Amelia | Fox Searchlight Pictures | $2,987 | -30.7% | -30.8% | 22 | $135 | $14,241,034 | 80 | - | false |
| 41 | 39 | Bitch Slap | Freestyle Releasing | $2,801 | -46.6% | - | 3 | $933 | $12,254 | 3 | - | false |
| 42 | 42 | Good Hair | Roadside Attractions | $1,122 | +21.2% | - | 3 | $374 | $4,149,065 | 94 | - | false |
| 43 | 43 | The Slammin' Salmon | Anchor Bay Films | $296 | -26% | - | 1 | $296 | $39,834 | 31 | - | false |
| 44 | - | The September Issue | Roadside Attractions | $30 | - | -94% | 1 | $30 | $3,818,032 | 136 | - | false |
| 45 | 44 | From Mexico with Love | Roadside Attractions | $3 | -66.7% | -50% | 1 | $3 | $548,787 | 94 | - | false |
