| TD | YD | Release
| Distributor
| Daily | %± YD | %± LW | Theaters | Avg | To Date | Days | New This Day
| Estimated
|
|---|
| 1 | 1 | The Final Destination | Warner Bros. | $2,233,058 | -65.1% | - | 3,121 | $715 | $29,641,367 | 4 | - | false |
| 2 | 2 | Inglourious Basterds | The Weinstein Company | $1,964,452 | -63.5% | -57.9% | 3,165 | $620 | $74,987,293 | 11 | - | false |
| 3 | 3 | Halloween II | - | $1,091,940 | -64.5% | - | 3,025 | $360 | $17,441,504 | 4 | - | false |
| 4 | 4 | District 9 | TriStar Pictures | $1,026,212 | -64.9% | -48.9% | 3,180 | $322 | $91,409,924 | 18 | - | false |
| 5 | 6 | Julie & Julia | Sony Pictures Releasing | $718,061 | -61% | -29.5% | 2,503 | $286 | $71,346,124 | 25 | - | false |
| 6 | 5 | G.I. Joe: The Rise of Cobra | Paramount Pictures | $583,025 | -70.2% | -48.9% | 3,467 | $168 | $132,734,979 | 25 | - | false |
| 7 | 7 | The Time Traveler's Wife | Warner Bros. | $577,115 | -62.6% | -45.9% | 2,961 | $194 | $48,477,533 | 18 | - | false |
| 8 | 8 | Shorts | Warner Bros. | $348,413 | -69.7% | -41.7% | 3,105 | $112 | $13,555,110 | 11 | - | false |
| 9 | 9 | Taking Woodstock | Focus Features | $295,590 | -64.4% | - | 1,393 | $212 | $3,773,925 | 6 | - | false |
| 10 | 10 | G-Force | Walt Disney Studios Motion Pictures | $231,319 | -70.6% | -44.3% | 1,926 | $120 | $112,011,669 | 39 | - | false |
| 11 | 11 | Harry Potter and the Half-Blood Prince | Warner Bros. | $228,130 | -67.6% | -43.8% | 1,508 | $151 | $294,486,205 | 48 | - | false |
| 12 | 13 | 500 Days of Summer | Fox Searchlight Pictures | $205,825 | -58.4% | -25.8% | 909 | $226 | $25,409,711 | 46 | - | false |
| 13 | 12 | Ponyo | Walt Disney Studios Motion Pictures | $169,082 | -68.8% | -35.7% | 880 | $192 | $11,202,338 | 18 | - | false |
| 14 | 14 | The Ugly Truth | Sony Pictures Releasing | $163,906 | -56.9% | -49.3% | 1,252 | $130 | $85,911,838 | 39 | - | false |
| 15 | 15 | The Goods: Live Hard, Sell Hard | Paramount Vantage | $144,506 | -57.3% | -61.3% | 1,426 | $101 | $13,962,434 | 18 | - | false |
| 16 | 16 | Post Grad | Twentieth Century Fox | $136,780 | -57.9% | -56.1% | 1,959 | $69 | $5,444,702 | 11 | - | false |
| 17 | 17 | The Hangover | Warner Bros. | $111,247 | -61% | -27.4% | 801 | $138 | $270,349,000 | 88 | - | false |
| 18 | 20 | Transformers: Revenge of the Fallen | DreamWorks | $52,819 | -64.2% | -44.1% | 622 | $84 | $399,468,859 | 69 | - | false |
| 19 | 18 | Ice Age: Dawn of the Dinosaurs | Twentieth Century Fox | $46,724 | -70.7% | -40.7% | 432 | $108 | $193,296,935 | 62 | - | false |
| 20 | 24 | Funny People | Universal Pictures | $37,170 | -55% | -68% | 413 | $90 | $51,361,540 | 32 | - | false |
| 21 | 26 | Under the Sea 3D | Warner Bros. | $35,174 | -55.8% | -33% | 108 | $325 | $16,726,979 | 200 | - | false |
| 22 | 21 | Adam | Fox Searchlight Pictures | $32,842 | -64.3% | +14.2% | 177 | $185 | $1,393,329 | 34 | - | false |
| 23 | 23 | Orphan | Warner Bros. | $32,776 | -61.4% | -63.4% | 482 | $68 | $40,644,256 | 39 | - | false |
| 24 | 22 | A Perfect Getaway | Universal Pictures | $32,640 | -62.5% | -71% | 544 | $60 | $15,034,335 | 25 | - | false |
| 25 | 25 | The Hurt Locker | Summit Entertainment | $30,149 | -63.3% | -30.5% | 306 | $98 | $11,626,061 | 67 | - | false |
| 26 | 19 | Aliens in the Attic | Twentieth Century Fox | $29,875 | -79.8% | -45.5% | 574 | $52 | $23,017,377 | 32 | - | false |
| 27 | 27 | My Sister's Keeper | Warner Bros. | $27,429 | -63.4% | +52.5% | 326 | $84 | $48,435,348 | 67 | - | false |
| 28 | 29 | The September Issue | Roadside Attractions | $27,032 | -52.6% | - | 6 | $4,505 | $247,665 | 4 | - | false |
| 29 | 30 | Star Trek | Paramount Pictures | $21,520 | -50.7% | -24.4% | 218 | $98 | $256,694,793 | 116 | - | false |
| 30 | 28 | Night at the Museum: Battle of the Smithsonian | Twentieth Century Fox | $20,244 | -67.6% | -41.3% | 232 | $87 | $176,482,152 | 102 | - | false |
| 31 | 31 | Public Enemies | Universal Pictures | $17,160 | -60.6% | -38.7% | 264 | $65 | $97,047,885 | 62 | - | false |
| 32 | 32 | Paper Heart | Overture Films | $13,320 | -55.5% | -23.9% | 96 | $138 | $951,473 | 25 | - | false |
| 33 | 34 | My One and Only | Freestyle Releasing | $8,486 | -63.3% | +26.5% | 10 | $848 | $174,127 | 11 | - | false |
| 34 | 33 | Bandslam | Summit Entertainment | $6,899 | -74.4% | -93.1% | 207 | $33 | $4,942,769 | 18 | - | false |
| 35 | 36 | The Cove | Roadside Attractions | $6,242 | -53.8% | -31.1% | 25 | $249 | $625,709 | 32 | - | false |
| 36 | 35 | Kaminey | UTV Motion Pictures | $4,350 | -80.5% | -60.9% | 63 | $69 | $1,208,927 | 18 | - | false |
| 37 | 37 | Terminator Salvation | Warner Bros. | $3,092 | -70% | -56.3% | 81 | $38 | $125,289,981 | 103 | - | false |
| 38 | 39 | The Collector | Freestyle Releasing | $2,717 | -56.6% | -68.2% | 37 | $73 | $7,547,513 | 32 | - | false |
| 39 | 38 | I Love You, Beth Cooper | Twentieth Century Fox | $2,622 | -67.8% | -60.2% | 77 | $34 | $14,709,366 | 53 | - | false |
| 40 | 41 | Spread | Anchor Bay Films | $1,796 | -57.4% | -11.9% | 45 | $39 | $240,981 | 18 | - | false |
| 41 | 43 | Brighton Rock | Rialto Pictures | $1,398 | -43.2% | - | 1 | $1,398 | $36,378 | 74 | - | false |
| 42 | 42 | X-Men Origins: Wolverine | Twentieth Century Fox | $1,355 | -57% | -47.5% | 26 | $52 | $179,864,899 | 123 | - | false |
| 43 | 44 | Shrink | Roadside Attractions | $896 | -60.2% | +611.1% | 8 | $112 | $180,461 | 39 | - | false |
| 44 | 45 | The Open Road | Anchor Bay Films | $668 | -69% | - | 14 | $47 | $13,991 | 4 | - | false |
| 45 | 46 | Mystery Team | Roadside Attractions | $369 | -71.9% | - | 1 | $369 | $8,209 | 4 | - | false |
| 46 | 48 | Z | Rialto Pictures | $160 | -61.9% | - | 1 | $160 | $80,508 | 172 | - | false |
| 47 | 50 | Goodbye Solo | Roadside Attractions | $98 | -29.5% | +133.3% | 5 | $19 | $866,887 | 158 | - | false |
| 48 | 49 | American Casino | Argot Pictures | $75 | -67.1% | -58.3% | 1 | $75 | $7,255 | 18 | - | false |
| 49 | 47 | The Stoning of Soraya M. | Roadside Attractions | $65 | -87.2% | -92.8% | 4 | $16 | $621,741 | 67 | - | false |
