| TD | YD | Release
| Distributor
| Daily | %± YD | %± LW | Theaters | Avg | To Date | Days | New This Day
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | Warner Bros. | $9,924,409 | -54.4% | - | 4,325 | $2,294 | $167,946,763 | 6 | - | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | Twentieth Century Fox | $2,375,203 | -52.5% | -34.5% | 3,817 | $622 | $154,241,190 | 20 | - | false |
| 3 | 3 | Transformers: Revenge of the Fallen | DreamWorks | $1,775,616 | -54.6% | -42.4% | 3,857 | $460 | $365,583,739 | 27 | - | false |
| 4 | 7 | The Proposal | Walt Disney Studios Motion Pictures | $1,201,054 | -45.5% | -17.3% | 3,043 | $394 | $129,284,327 | 32 | - | false |
| 5 | 4 | Brüno | Universal Pictures | $1,172,575 | -50% | -67.6% | 2,759 | $425 | $50,706,050 | 11 | - | false |
| 6 | 5 | The Hangover | Warner Bros. | $1,118,139 | -50.6% | -15.4% | 2,667 | $419 | $236,862,562 | 46 | - | false |
| 7 | 6 | Public Enemies | Universal Pictures | $1,012,995 | -54.6% | -38% | 3,118 | $324 | $80,652,200 | 20 | - | false |
| 8 | 10 | I Love You, Beth Cooper | Twentieth Century Fox | $548,728 | -26.8% | -31.3% | 1,872 | $293 | $10,911,967 | 11 | - | false |
| 9 | 9 | My Sister's Keeper | Warner Bros. | $496,426 | -38.8% | -31.8% | 1,967 | $252 | $42,004,121 | 25 | - | false |
| 10 | 8 | Up | Walt Disney Studios Motion Pictures | $480,509 | -47.4% | -30.5% | 1,706 | $281 | $280,063,791 | 53 | - | false |
| 11 | 11 | 500 Days of Summer | Fox Searchlight Pictures | $125,900 | -51.8% | - | 27 | $4,662 | $960,401 | 4 | - | false |
| 12 | 15 | Night at the Museum: Battle of the Smithsonian | Twentieth Century Fox | $111,804 | -40.3% | -36.7% | 515 | $217 | $171,932,169 | 60 | - | false |
| 13 | 12 | The Taking of Pelham 123 | Sony Pictures Releasing | $102,773 | -56.8% | -42.3% | 610 | $168 | $63,003,083 | 39 | - | false |
| 14 | 13 | The Hurt Locker | Summit Entertainment | $94,408 | -57.7% | +21% | 94 | $1,004 | $2,243,027 | 25 | - | false |
| 15 | 14 | Star Trek | Paramount Pictures | $87,039 | -53.8% | -41.5% | 505 | $172 | $253,251,652 | 74 | - | false |
| 16 | 19 | Under the Sea 3D | Warner Bros. | $71,496 | -16.9% | -2.9% | 40 | $1,787 | $12,966,036 | 158 | - | false |
| 17 | 16 | Away We Go | Focus Features | $65,679 | -51.5% | -25.2% | 299 | $219 | $8,349,204 | 46 | - | false |
| 18 | 20 | Terminator Salvation | Warner Bros. | $45,946 | -45% | +33.2% | 195 | $235 | $123,815,608 | 61 | - | false |
| 19 | 22 | Land of the Lost | Universal Pictures | $38,715 | -48.2% | -20.2% | 267 | $145 | $48,647,020 | 46 | - | false |
| 20 | 21 | Chéri | Miramax | $33,615 | -57.7% | -13.3% | 191 | $175 | $2,040,534 | 25 | - | false |
| 21 | 23 | Ghosts of Girlfriends Past | Warner Bros. | $33,445 | -45% | +16.8% | 222 | $150 | $54,816,117 | 81 | - | false |
| 22 | 24 | X-Men Origins: Wolverine | Twentieth Century Fox | $30,280 | -45.6% | -26.2% | 226 | $133 | $179,223,801 | 81 | - | false |
| 23 | 25 | Monsters vs. Aliens | DreamWorks | $29,630 | -41.6% | -21.9% | 230 | $128 | $197,512,077 | 116 | - | false |
| 24 | 26 | 17 Again | Warner Bros. | $22,329 | -54.6% | +65% | 132 | $169 | $63,942,143 | 95 | - | false |
| 25 | 27 | Drag Me to Hell | Universal Pictures | $22,045 | -46.6% | -26.7% | 192 | $114 | $41,725,850 | 53 | - | false |
| 26 | 29 | Dance Flick | Paramount Pictures | $10,939 | -55% | -44.7% | 113 | $96 | $25,626,731 | 60 | - | false |
| 27 | 28 | Imagine That | Paramount Pictures | $10,350 | -62.7% | -46.5% | 144 | $71 | $15,315,932 | 39 | - | false |
| 28 | 30 | The Stoning of Soraya M. | Roadside Attractions | $8,677 | -62.3% | +51.8% | 34 | $255 | $444,182 | 25 | - | false |
| 29 | 31 | My Life in Ruins | Fox Searchlight Pictures | $6,833 | -45.9% | -2.8% | 61 | $112 | $8,481,441 | 46 | - | false |
| 30 | 32 | The Brothers Bloom | Summit Entertainment | $4,615 | -48.3% | -21.3% | 68 | $67 | $3,431,037 | 67 | - | false |
| 31 | 34 | Battle for Terra | Lionsgate | $854 | -26% | - | 2 | $427 | $1,643,645 | 81 | - | false |
| 32 | 35 | Goodbye Solo | Roadside Attractions | $625 | -16.6% | -65.5% | 13 | $48 | $836,788 | 116 | - | false |
| 33 | 37 | War Eagle, Arkansas | Hannover House | $535 | +33.4% | +6,587.5% | 2 | $267 | $60,795 | 39 | - | false |
| 34 | 36 | Z | Rialto Pictures | $103 | -84.1% | -60.5% | 1 | $103 | $69,616 | 130 | - | false |
| 35 | 38 | Throw Down Your Heart | Argot Pictures | $68 | -81.1% | - | 1 | $68 | $88,647 | 130 | - | false |
