| TD | YD | Release
| Distributor
| Daily | %± YD | %± LW | Theaters | Avg | To Date | Days | New This Day
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | Twentieth Century Fox | $3,626,785 | -55% | -45.1% | 4,102 | $884 | $123,306,978 | 13 | - | false |
| 2 | 2 | Brüno | Universal Pictures | $3,624,140 | -51.5% | - | 2,756 | $1,315 | $34,243,270 | 4 | - | false |
| 3 | 3 | Transformers: Revenge of the Fallen | DreamWorks | $3,084,025 | -56.5% | -51.9% | 4,293 | $718 | $342,305,825 | 20 | - | false |
| 4 | 4 | Public Enemies | Universal Pictures | $1,634,640 | -59.5% | -53.7% | 3,336 | $490 | $67,855,750 | 13 | - | false |
| 5 | 6 | The Proposal | Walt Disney Studios Motion Pictures | $1,451,563 | -49% | -33.1% | 3,158 | $459 | $115,312,639 | 25 | - | false |
| 6 | 5 | The Hangover | Warner Bros. | $1,321,308 | -53.8% | -33.2% | 3,002 | $440 | $223,766,214 | 39 | - | false |
| 7 | 9 | I Love You, Beth Cooper | Twentieth Century Fox | $798,340 | -33.8% | - | 1,858 | $429 | $5,717,773 | 4 | - | false |
| 8 | 8 | My Sister's Keeper | Warner Bros. | $728,293 | -42.1% | -42.5% | 2,444 | $297 | $36,644,075 | 18 | - | false |
| 9 | 7 | Up | Walt Disney Studios Motion Pictures | $691,309 | -49.6% | -33.2% | 2,201 | $314 | $274,526,070 | 46 | - | false |
| 10 | 10 | The Taking of Pelham 123 | Sony Pictures Releasing | $178,113 | -58.2% | -49.7% | 1,116 | $159 | $61,616,068 | 32 | - | false |
| 11 | 11 | Night at the Museum: Battle of the Smithsonian | Twentieth Century Fox | $176,695 | -48.1% | -44.4% | 854 | $206 | $170,661,879 | 53 | - | false |
| 12 | 13 | Year One | Sony Pictures Releasing | $154,289 | -44.3% | -69.7% | 990 | $155 | $41,346,770 | 25 | - | false |
| 13 | 12 | Star Trek | Paramount Pictures | $148,804 | -52.8% | -40.5% | 763 | $195 | $252,119,599 | 67 | - | false |
| 14 | 14 | Away We Go | Focus Features | $87,802 | -57.1% | -40.6% | 406 | $216 | $7,508,377 | 39 | - | false |
| 15 | 15 | The Hurt Locker | Summit Entertainment | $78,005 | -61.5% | +266.8% | 60 | $1,300 | $1,179,839 | 18 | - | false |
| 16 | 20 | Under the Sea 3D | Warner Bros. | $73,594 | -6.1% | +4.6% | 38 | $1,936 | $12,315,940 | 151 | - | false |
| 17 | 17 | Land of the Lost | Universal Pictures | $48,515 | -50.8% | -3.1% | 313 | $155 | $48,232,865 | 39 | - | false |
| 18 | 19 | X-Men Origins: Wolverine | Twentieth Century Fox | $41,006 | -48.7% | -19.1% | 279 | $146 | $178,882,397 | 74 | - | false |
| 19 | 16 | Chéri | Miramax | $38,786 | -61.9% | -17.3% | 173 | $224 | $1,607,553 | 18 | - | false |
| 20 | 22 | Monsters vs. Aliens | DreamWorks | $37,958 | -43.8% | -24.4% | 261 | $145 | $197,154,779 | 109 | - | false |
| 21 | 21 | Terminator Salvation | Warner Bros. | $34,504 | -50.4% | -32.9% | 221 | $156 | $123,142,908 | 54 | - | false |
| 22 | 23 | Drag Me to Hell | Universal Pictures | $30,055 | -48% | -32.8% | 241 | $124 | $41,479,220 | 46 | - | false |
| 23 | 24 | Ghosts of Girlfriends Past | Warner Bros. | $28,635 | -47.4% | -32.7% | 241 | $118 | $54,405,740 | 74 | - | false |
| 24 | 25 | Dance Flick | Paramount Pictures | $19,764 | -45.7% | +100.5% | 165 | $119 | $25,474,501 | 53 | - | false |
| 25 | 26 | Imagine That | Paramount Pictures | $19,357 | -46.7% | -53.5% | 209 | $92 | $15,139,710 | 32 | - | false |
| 26 | 27 | 17 Again | Warner Bros. | $13,534 | -35% | -43.2% | 121 | $111 | $63,585,375 | 88 | - | false |
| 27 | 29 | My Life in Ruins | Fox Searchlight Pictures | $7,027 | -55.9% | -31.6% | 80 | $87 | $8,400,131 | 39 | - | false |
| 28 | 30 | The Brothers Bloom | Summit Entertainment | $5,867 | -51.7% | -48% | 90 | $65 | $3,372,425 | 60 | - | false |
| 29 | 28 | The Stoning of Soraya M. | Roadside Attractions | $5,717 | -67% | -36% | 25 | $228 | $344,409 | 18 | - | false |
| 30 | 31 | Tetro | American Zoetrope | $2,508 | -63% | -31.2% | 10 | $250 | $275,700 | 33 | - | false |
| 31 | 32 | Goodbye Solo | Roadside Attractions | $1,811 | -45.2% | +64.6% | 20 | $90 | $828,574 | 109 | - | false |
| 32 | 33 | Is Anybody There? | - | $921 | -34.1% | +14.1% | 7 | $131 | $2,025,146 | 88 | - | false |
| 33 | 35 | Sin Nombre | Focus Features | $545 | -33.3% | -30.6% | 7 | $77 | $2,534,896 | 116 | - | false |
| 34 | 34 | Z | Rialto Pictures | $261 | -76.6% | - | 1 | $261 | $65,703 | 123 | - | false |
| 35 | 38 | War Eagle, Arkansas | Hannover House | $8 | -92.7% | -94.2% | 1 | $8 | $46,350 | 32 | - | false |
