| Rank
| Release
| Lifetime Gross | Max Theaters | Opening | Open Th | Release Date | Distributor
| Estimated
|
|---|
| 1 | National Lampoon's Animal House | $120,091,123 | 12 | $276,538 | 12 | Jul 28, 1978 | Universal Pictures | false |
| 2 | National Lampoon's Christmas Vacation | $71,319,526 | 1,950 | $11,750,203 | 1,744 | Dec 1, 1989 | Warner Bros. | false |
| 3 | Vacation | $61,399,552 | 1,253 | $8,333,358 | 1,175 | Jul 29, 1983 | Warner Bros. | false |
| 4 | National Lampoon's European Vacation | $49,364,621 | 1,547 | $12,329,627 | 1,546 | Jul 26, 1985 | Warner Bros. | false |
| 5 | Vegas Vacation | $36,400,360 | 2,070 | $12,837,927 | 2,054 | Feb 14, 1997 | Warner Bros. | false |
| 6 | Loaded Weapon 1 | $27,979,399 | 2,015 | $9,202,722 | 1,989 | Feb 5, 1993 | New Line Cinema | false |
| 7 | National Lampoon's Animal House 1979 Re-release | $21,508,877 | 40 | $201,747 | 40 | Sep 21, 1979 | Universal Pictures | false |
| 8 | National Lampoon's Van Wilder | $21,305,259 | 2,104 | $7,302,913 | 2,022 | Apr 5, 2002 | Artisan Entertainment | false |
| 9 | Class Reunion | $10,054,150 | 1,125 | $3,086,525 | 1,121 | Oct 29, 1982 | Twentieth Century Fox | false |
| 10 | National Lampoon's Senior Trip | $4,686,937 | 1,397 | $2,184,901 | 1,397 | Sep 8, 1995 | New Line Cinema | false |
| 11 | Joy of Sex | $4,463,841 | 804 | $1,913,001 | 804 | Aug 3, 1984 | Paramount Pictures | false |
| 12 | Van Wilder: The Rise of Taj | $4,300,645 | 1,979 | $2,313,372 | 1,979 | Dec 1, 2006 | Metro-Goldwyn-Mayer (MGM) | false |
| 13 | National Lampoon's Christmas Vacation 2019 Re-release | $1,385,620 | - | - | - | Nov 1, 2019 | Warner Bros. | false |
| 14 | National Lampoon's Christmas Vacation 2021 Re-release | $939,753 | - | - | - | Jan 1, 2021 | Warner Bros. | false |
| 15 | National Lampoon's Christmas Vacation 2020 Re-release | $871,000 | 620 | $170,000 | 308 | Nov 25, 2020 | Warner Bros. | true |
| 16 | Gold Diggers | $527,000 | 1,062 | $403,164 | 1,062 | Sep 17, 2004 | - | true |
| 17 | Movie Madness | $63,405 | - | - | - | Apr 23, 1982 | United Artists | false |
| 18 | Dorm Daze | $56,127 | 34 | $27,712 | 34 | Sep 24, 2003 | 120 Degree Films | false |
| 19 | Blackball 2005 Re-release | $48,000 | 8 | $48,000 | 8 | Feb 11, 2005 | First Look International | false |
| 20 | O.C. and Stiggs | $29,815 | 18 | $6,273 | 18 | Jul 10, 1987 | Metro-Goldwyn-Mayer (MGM) | false |
| 21 | Barely Legal | $26,511 | 20 | $15,766 | 20 | Oct 21, 2005 | Sony Pictures Releasing | false |
| 22 | Vacation 2021 Re-release | $18,511 | - | - | - | - | Warner Bros. | false |
