| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $10,801,779 | 35 | $13,488,099 | Dec 17 | 20th Century Fox International | false |
| 2 | Alice in Wonderland | - | - | - | $4,927,834 | 66 | $4,927,834 | Mar 18 | Walt Disney Pictures | false |
| 3 | Shrek Forever After | - | - | - | $4,516,709 | 67 | $4,516,709 | Jul 1 | United International Pictures | false |
| 4 | Toy Story 3 | - | - | - | $4,423,739 | 58 | $4,423,739 | Jun 17 | Walt Disney Pictures | false |
| 5 | Inception | - | - | - | $3,669,899 | 31 | $3,669,899 | Jul 22 | Warner Bros. | false |
| 6 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $2,339,410 | 36 | $2,457,641 | Nov 18 | Warner Bros. | false |
| 7 | How to Train Your Dragon | - | - | - | $2,070,355 | 44 | $2,070,355 | Mar 25 | United International Pictures | false |
| 8 | Tangled | - | - | - | $1,799,194 | 48 | $2,400,516 | Nov 25 | Walt Disney Pictures | false |
| 9 | Despicable Me | - | - | - | $1,704,133 | 40 | $1,704,133 | Aug 5 | United International Pictures | false |
| 10 | Prince of Persia: The Sands of Time | - | - | - | $1,410,961 | 40 | $1,522,120 | May 20 | Walt Disney Pictures | false |
| 11 | The Princess and the Frog | - | - | - | $1,333,251 | 36 | $1,333,251 | Feb 25 | Walt Disney Pictures | false |
| 12 | Eat Pray Love | - | - | - | $1,312,186 | 23 | $1,466,614 | Sep 23 | Sony Pictures Releasing | false |
| 13 | Sex and the City 2 | - | - | - | $1,267,878 | 42 | $1,271,351 | May 27 | Warner Bros. | false |
| 14 | Shutter Island | - | - | - | $1,230,486 | 28 | $1,230,486 | Feb 25 | United International Pictures | false |
| 15 | Salt | - | - | - | $1,190,082 | 29 | $1,190,082 | Jul 29 | Sony Pictures Releasing | false |
| 16 | The Social Network | - | - | - | $1,152,614 | 20 | $1,257,065 | Oct 28 | Sony Pictures Releasing | false |
| 17 | Robin Hood | - | - | - | $1,144,051 | 30 | $1,144,051 | May 13 | United International Pictures | false |
| 18 | The Town | - | - | - | $1,118,571 | 27 | $1,173,541 | Oct 14 | Warner Bros. | false |
| 19 | Sherlock Holmes | - | - | - | $1,118,066 | 27 | $1,178,865 | Dec 31 | Warner Bros. | false |
| 20 | Due Date | - | - | - | $1,038,923 | 27 | $1,270,218 | Dec 2 | Warner Bros. | false |
| 21 | It's Complicated | - | - | - | $1,017,436 | 30 | $1,081,231 | Jan 14 | United International Pictures | false |
| 22 | Grown Ups | - | - | - | $1,005,070 | 19 | $1,005,070 | Jul 8 | Sony Pictures Releasing | false |
| 23 | Megamind | - | - | - | $997,806 | 55 | $1,339,654 | Dec 2 | United International Pictures | false |
| 24 | Clash of the Titans | - | - | - | $922,528 | 27 | $922,528 | Apr 15 | Warner Bros. | false |
| 25 | The Last Airbender | - | - | - | $813,126 | 38 | $813,126 | Jul 22 | United International Pictures | false |
| 26 | Knight and Day 2010 Re-release | - | - | - | $809,128 | 28 | $809,128 | Jul 15 | 20th Century Fox International | false |
| 27 | The Karate Kid | - | - | - | $779,612 | 25 | $779,612 | Aug 12 | Sony Pictures Releasing | false |
| 28 | The Bounty Hunter | - | - | - | $742,986 | 20 | $742,986 | Mar 25 | Sony Pictures Releasing | false |
| 29 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $712,280 | 41 | $712,280 | Jul 29 | Warner Bros. | false |
| 30 | The Sorcerer's Apprentice | - | - | - | $709,294 | 21 | $709,294 | Jul 15 | Walt Disney Pictures | false |
| 31 | Life as We Know It | - | - | - | $691,515 | 18 | $725,513 | Nov 4 | Warner Bros. | false |
| 32 | Iron Man 2 | - | - | - | $684,653 | 31 | $684,653 | Apr 29 | United International Pictures | false |
| 33 | Date Night | - | - | - | $671,771 | 13 | $671,771 | May 6 | 20th Century Fox International | false |
| 34 | Jackass 3D | - | - | - | $641,971 | 25 | $654,910 | Nov 11 | United International Pictures | false |
| 35 | Up in the Air | - | - | - | $607,943 | 22 | $673,504 | Feb 4 | United International Pictures | false |
| 36 | Tron: Legacy | - | - | - | $587,632 | 22 | $810,846 | Dec 16 | Walt Disney Pictures | false |
| 37 | The Blind Side | - | - | - | $568,626 | 20 | $568,626 | Mar 25 | Warner Bros. | false |
| 38 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $565,874 | 48 | $571,479 | Sep 23 | Warner Bros. | false |
| 39 | Valentine's Day | - | - | - | $520,626 | 28 | $520,626 | Feb 11 | Warner Bros. | false |
| 40 | The Other Guys | - | - | - | $515,757 | 20 | $515,757 | Sep 23 | Sony Pictures Releasing | false |
| 41 | Going the Distance | - | - | - | $449,949 | 17 | $449,949 | Sep 9 | Warner Bros. | false |
| 42 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $416,788 | 21 | $416,788 | Feb 18 | 20th Century Fox International | false |
| 43 | Scott Pilgrim vs. the World | - | - | - | $403,070 | 18 | $415,524 | Sep 23 | United International Pictures | false |
| 44 | Old Dogs | - | - | - | $393,224 | 16 | $393,224 | Jan 21 | Walt Disney Pictures | false |
| 45 | The Chronicles of Narnia: The Voyage of the Dawn Treader | - | - | - | $329,132 | 41 | $813,599 | Dec 9 | 20th Century Fox International | false |
| 46 | When in Rome | - | - | - | $322,406 | 18 | $323,434 | Apr 15 | Walt Disney Pictures | false |
| 47 | Did You Hear About the Morgans? | - | - | - | $309,558 | 11 | $309,558 | Feb 18 | Sony Pictures Releasing | false |
| 48 | Wall Street: Money Never Sleeps | - | - | - | $290,125 | 19 | $290,125 | Sep 30 | 20th Century Fox International | false |
| 49 | Little Fockers | - | - | - | $283,430 | 28 | $882,668 | Dec 23 | United International Pictures | false |
| 50 | The Back-up Plan | - | - | - | $269,248 | 15 | $269,248 | Jun 10 | Sony Pictures Releasing | false |
| 51 | Unstoppable | - | - | - | $258,386 | 18 | $258,386 | Nov 18 | 20th Century Fox International | false |
| 52 | Everybody's Fine | - | - | - | $245,045 | 13 | $379,816 | Dec 24 | Walt Disney Pictures | false |
| 53 | You Again | - | - | - | $237,242 | 15 | $237,242 | Oct 28 | Walt Disney Pictures | false |
| 54 | Resident Evil: Afterlife | - | - | - | $229,285 | 20 | $423,771 | Sep 9 | - | false |
| 55 | Dear John | - | - | - | $226,731 | 11 | $226,731 | Apr 1 | Sony Pictures Releasing | false |
| 56 | Invictus | - | - | - | $216,409 | 16 | $216,409 | Jan 21 | Warner Bros. | false |
| 57 | Nanny McPhee Returns | - | - | - | $208,401 | 24 | $208,401 | Jul 15 | United International Pictures | false |
| 58 | The A-Team | - | - | - | $197,783 | 49 | $197,783 | Aug 19 | 20th Century Fox International | false |
| 59 | Couples Retreat | - | - | - | $197,778 | 29 | $785,683 | Dec 10 | United International Pictures | false |
| 60 | Leap Year | - | - | - | $197,515 | 17 | $213,780 | Jan 14 | Forum Hungary | false |
| 61 | Paranormal Activity 2 | - | - | - | $181,584 | 15 | $238,379 | Dec 9 | United International Pictures | false |
| 62 | A Nightmare on Elm Street | - | - | - | $171,579 | 10 | $171,579 | Jun 10 | Warner Bros. | false |
| 63 | 2012 | - | - | - | $152,830 | 29 | $2,675,652 | Nov 12 | Sony Pictures Releasing | false |
| 64 | The Men Who Stare at Goats | - | - | - | $96,173 | 5 | $96,173 | Jan 28 | Sony Pictures Releasing | false |
| 65 | Black Lightning | - | - | - | $95,643 | 10 | $95,643 | Jan 7 | United International Pictures | false |
| 66 | The Lovely Bones | - | - | - | $73,342 | 16 | $73,342 | Mar 4 | United International Pictures | false |
| 67 | Takers 2010 Re-release | - | - | - | $57,418 | 3 | $57,418 | Oct 14 | Sony Pictures Releasing | false |
| 68 | Easy A | - | - | - | $38,959 | 3 | $38,959 | Nov 25 | Sony Pictures Releasing | false |
| 69 | A Christmas Carol | - | - | - | $11,788 | 18 | $447,277 | Nov 26 | Walt Disney Pictures | false |
| 70 | Where the Wild Things Are | - | - | - | $11,732 | 12 | $183,891 | Dec 10 | Warner Bros. | false |
